Výsledky vyhledávání - "Kazuyuki Fujishima"

Effects of amrinone on renal blood flow and cardiac function, in comparison with those of milrinone and olprinone, in anesthetized dog

Autor: Mitugu Hachisu, Akihiko Yamamoto, Kazuyuki Fujishima

Publikováno v: Folia Pharmacologica Japonica. 112:371-380

Amrinone, one of the phosphodiesterase III inhibitors, is clinically used for acute heart failure and possesses diuretic action, which is not observed in other phosphodiesterase III inhibitors. To clarify the mechanism of the diuretic action of amrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a56af1b94fcf33441cfc3c13a9399b3
https://doi.org/10.1254/fpj.112.371

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Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist

Autor: Fukio Konno, Mitsugu Hachisu, Mikio Yamamoto, Hiroko Ogino, Kazuyuki Fujishima, Kiyoaki Katano, Chen Hui, Ken-ichi Kawano, Sumie Yasuda, Jun Nagura

Publikováno v: European Journal of Pharmacology. 274:201-211

The pharmacological profile of a new surmountable angiotensin AT1 receptor antagonist, ME3221, 3-methoxy-2,6-dimethyl-4-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4- yl]methoxy]pyridine, was studied in several animal models, and was compared with that of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bfb30e743e57195b0aef61dc379a7c
https://doi.org/10.1016/0014-2999(94)00740-x

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Tricyclic pharmacophore-based molecules as novel integrin alphavbeta3 antagonists. Part IV: preliminary control of alphavbeta3 selectivity by meta-oriented substitution

Autor: Midori Ishikawa, Minoru Ishikawa, Dai Kubota, Kazuyuki Fujishima, Masafumi Kitakaze, Naokazu Yahata, Shoichi Murakami, Keiichi Ajito

Publikováno v: Bioorganicmedicinal chemistry. 14(12)

To establish the in vivo efficacy of alphavbeta3/alphaIIbbeta3 dual antagonists possessing a tricyclic pharmacophore, a corresponding alphavbeta3-selective antagonist was required as a control. We initially took two synthetic approaches to obtain alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69de1afdea2a1fa9087bbc2ce492621e
https://pubmed.ncbi.nlm.nih.gov/16504518

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Endovascular photodynamic therapy using mono-L-aspartyl-chlorin e6 to inhibit Intimal hyperplasia in balloon-injured rabbit arteries

Autor: Katsuo Aizawa, Tsuneyuki Nagae, Kazuyuki Fujishima, Mitsuhiro Abe, Shin Ishimaru, Norio Uchimura, Samuel E. Wilson, Daisuke Tani

Publikováno v: Lasers in surgery and medicine. 28(4)

Background and Objective Intimal hyperplasia (IH) leading to restenosis is a major complication of arterial revascularization. The purpose of this study was to investigate the effect of photodynamic therapy (PDT) using mono-L-aspartyl chlorin e6 (NPe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01f193c1b88aca02d3f331ba53ae537
https://pubmed.ncbi.nlm.nih.gov/11344521

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ME3277, a GPIIb/IIIa antagonist reduces cerebral infarction without enhancing intracranial hemorrhage in photothrombotic occlusion of rabbit middle cerebral artery

Autor: Kazuo Umemura, Kazunao Kondo, Yasuhiko Ikeda, Ken Ichi Kawano, Kazuyuki Fujishima

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 20(6)

GPIIb/IIIa antagonists are expected to have a beneficial effect on acute cerebral infarction, however, the occurrence of intracranial hemorrhage has not been as widely investigated. A rabbit focal thrombotic occlusion model of the middle cerebral art

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747f19c9dbd4b4756cf2efddf141662c
https://pubmed.ncbi.nlm.nih.gov/10894182

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[Effects of amrinone, an inhibitor of c-AMP-specific phosphodiesterases, on neointimal hyperplasia after balloon injury in rats]

Autor: Kazuyuki Fujishima, Misako Nomura, Mitsugu Hachisu

Publikováno v: Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 112(4)

Amrinone(5-amino(3,4'-bibyridin)6-(1H)-one), an inhibitor of c-AMP-specific phosphodiesterases, has been used clinically as an inodilator. We have investigated the effect of amrinone on neointimal hyperplasia in rat carotid artery after balloon injur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcee35d4d766e415b91ce01bd176c03
https://pubmed.ncbi.nlm.nih.gov/9866844

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Nonpeptide angiotensin II receptor antagonist recognizes inter-species differences in angiotensin AT1 receptors

Autor: Sumie Yasuda, Ken-ichi Kawano, Jun Nagura, Kazuyuki Fujishima, Mitsugu Hachisu, Shinki, Fukio Konno

Publikováno v: European journal of pharmacology. 357(1)

Oral administration of the angiotensin AT1 receptor antagonist 3-methyl-2,6-dimethyl-4-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl ]methoxy] pyridine (ME3221) inhibited the pressor response to angiotensin II at doses of 0.3-1.0 mg/kg in rats. A higher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b650de571ee2514271c8b13974425e
https://pubmed.ncbi.nlm.nih.gov/9788771

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