Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

Autor: Wing Lee Chan, Magdalena Steiner, Tomasz Witkos, Johannes Egerer, Björn Busse, Shuji Mizumoto, Jan M Pestka, Haikuo Zhang, Ingrid Hausser, Layal Abo Khayal, Claus-Eric Ott, Mateusz Kolanczyk, Bettina Willie, Thorsten Schinke, Chiara Paganini, Antonio Rossi, Kazuyuki Sugahara, Michael Amling, Petra Knaus, Danny Chan, Martin Lowe, Stefan Mundlos, Uwe Kornak

Publikováno v: PLoS Genetics, Vol 14, Iss 3, p e1007242 (2018)

Gerodermia osteodysplastica (GO) is characterized by skin laxity and early-onset osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of poorly characterized function. To circumvent neonatal lethality of the GorabNull full

Externí odkaz: https://doaj.org/article/d57661c1748c402db63c5dbeb8b9b7d0

Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis.

Autor: Kenji Suzuki, Somasundaram Arumugam, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, Hiroki Sato, Yutaka Aoyagi, Shuji Terai, Kazuichi Okazaki, Yasuo Suzuki, Shuji Mizumoto, Kazuyuki Sugahara, Raja Atreya, Markus F Neurath, Kenichi Watanabe, Taishi Hashiguchi, Hiroyuki Yoneyama, Hitoshi Asakura

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0158967 (2016)

Induction of mucosal healing (MH) is an important treatment goal in inflammatory bowel disease (IBD). Although the molecular mechanisms underlying MH in IBD is not fully explored, local fibrosis would contribute to interfere mucosal repair. Carbohydr

Externí odkaz: https://doaj.org/article/bdc39cdabfa94c89bba24d1bfc1d6290

Hyaluronidases Have Strong Hydrolytic Activity toward Chondroitin 4-Sulfate Comparable to that for Hyaluronan

Autor: Shuhei Yamada, Kazuyuki Sugahara, Shuji Mizumoto, Tomoko Honda, Tomoyuki Kaneiwa

Publikováno v: Biomolecules, Vol 2, Iss 4, Pp 549-563 (2012)

Chondroitin sulfate (CS) chains are involved in the regulation of various biological processes. However, the mechanism underlying the catabolism of CS is not well understood. Hyaluronan (HA)-degrading enzymes, the hyaluronidases, are assumed to act a

Externí odkaz: https://doaj.org/article/8e94d2c40b28475b9d70a24f6bfa4778

[Comparative Verification of DNA Extraction Methods for Bacterial Nucleic Acid Amplification Test]

Autor: Yuya, Hirata, Kazuyuki, Sugahara, Hiroki, Hanaiwa, Yumiko, Funashima, Kenichi, Sato, Zenzo, Nagasawa, Tsukuru, Umemura

Publikováno v: Rinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology. 29(2)

Genetic testing is widely used as a rapid diagnostic method to identify microorganisms and detect antibiotic resistance genes. The nucleic acid to be analyzed is located inside the cell wall, the cell membrane or nuclear envelope. Therefore, it is es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::befb884fb944e5f293c8ce7ed6417b76
https://pubmed.ncbi.nlm.nih.gov/32312079

Investigation of Action Pattern of a Novel Chondroitin Sulfate/Dermatan Sulfate 4- O -Endosulfatase

Autor: José L. Neira, Cédric Przybylski, Kazuyuki Sugahara, Fuchuan Li, Régis Daniel, Runmiao Jiao, Wenshuang Wang, Liran Shi, Cai Xiaojuan, Chrystel Lopin-Bon

Publikováno v: Biochemical Journal
Biochemical Journal, 2020, 478 (2), pp.281-298. ⟨10.1042/BCJ20200657⟩
Biochemical Journal, Portland Press, 2020, 478 (2), pp.281-298. ⟨10.1042/BCJ20200657⟩

International audience; Recently, a novel CS/DS 4-O-endosulfatase was identified from a marine bacterium and its catalytic mechanism was investigated further (Wang, W., et. al (2015) J. Biol. Chem.290, 7823–7832; Wang, S., et. al (2019) Front. Micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46ef2774c5e2bd7962bd00b53dae66c
https://univ-evry.hal.science/hal-03098070