Zobrazeno 1 - 10
of 455
pro vyhledávání: '"Kazuyuki, Tobe"'
Autor:
Asako Enkaku, Daisuke Chujo, Miki Kamigishi, Shinya Inagawa, Shinnosuke Matsukoshi, Waka Sakai, Akiko Takikawa, Shiho Fujisaka, Kazuyuki Tobe
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 4, Pp 437-448 (2024)
Abstract Aims/Introduction Endogenous insulin secretion could be recovered by improving hyperglycemia in patients with type 2 diabetes. This study aimed to investigate the association between short‐term recovery of insulin secretion during hospital
Externí odkaz:
https://doaj.org/article/d6022acade8746ba9cbc7b43368f7cf4
Autor:
Minehiko Inomata, Masahiro Matsumoto, Naoki Takata, Kana Hayashi, Zenta Seto, Takahiro Hirai, Kotaro Tokui, Chihiro Taka, Seisuke Okazawa, Kenta Kambara, Shingo Imanishi, Toshiro Miwa, Ryuji Hayashi, Shoko Matsui, Kazuyuki Tobe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Immune checkpoint inhibitors have significantly improved the prognosis in patients with non-small cell lung cancer, compared with cytotoxic agents. However, the prediction of treatment response is often difficult, even after assessing the tu
Externí odkaz:
https://doaj.org/article/b0def5af260d4ffb910a8901979993fb
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Macrophages contribute to adipose tissue homeostasis; however, they are also thought to be responsible for insulin resistance in obesity. Macrophages, which were oversimplified in past methodologies, have become rather difficult to understand compreh
Externí odkaz:
https://doaj.org/article/9d3039794f634c508880026e71d4f117
Autor:
Minehiko Inomata, Takeshi Tsuda, Tomomi Ichikawa, Masahiro Matsumoto, Isami Mizushima, Kenji Azechi, Naoki Takata, Nozomu Murayama, Kana Hayashi, Takahiro Hirai, Zenta Seto, Kotaro Tokui, Yasuaki Masaki, Chihiro Taka, Seisuke Okazawa, Kenta Kambara, Shingo Imanishi, Hirokazu Taniguchi, Toshiro Miwa, Ryuji Hayashi, Shoko Matsui, Kazuyuki Tobe
Publikováno v:
Thoracic Cancer, Vol 14, Iss 17, Pp 1618-1623 (2023)
Abstract Objective Studies have suggested the potential efficacy of immune checkpoint inhibitors (ICIs) for pulmonary sarcomatoid carcinoma. This multicenter observational study was conducted to evaluate the efficacy of systemic ICI therapy and chemo
Externí odkaz:
https://doaj.org/article/d017de19d4e6443389f1d93a76555a9a
Autor:
Yoshiyuki Watanabe, Shiho Fujisaka, Yoshitomo Morinaga, Shiro Watanabe, Allah Nawaz, Hideki Hatta, Tomonobu Kado, Ayumi Nishimura, Muhammad Bilal, Muhammad Rahil Aslam, Keiko Honda, Yoshimi Nakagawa, Samir Softic, Kenichi Hirabayashi, Takashi Nakagawa, Yoshinori Nagai, Kazuyuki Tobe
Publikováno v:
Molecular Metabolism, Vol 77, Iss , Pp 101797- (2023)
Objective: Polyphenols have health-promoting effects, such as improving insulin resistance. Isoxanthohumol (IX), a prenylated flavonoid found in beer hops, has been suggested to reduce obesity and insulin resistance; however, the mechanism remains un
Externí odkaz:
https://doaj.org/article/5e617e1c998c4930b7ab219ec79db80e
Autor:
Allah Nawaz, Muhammad Bilal, Shiho Fujisaka, Tomonobu Kado, Muhammad Rahil Aslam, Saeed Ahmed, Keisuke Okabe, Yoshiko Igarashi, Yoshiyuki Watanabe, Takahide Kuwano, Koichi Tsuneyama, Ayumi Nishimura, Yasuhiro Nishida, Seiji Yamamoto, Masakiyo Sasahara, Johji Imura, Hisashi Mori, Martin M. Matzuk, Fujimi Kudo, Ichiro Manabe, Akiyoshi Uezumi, Takashi Nakagawa, Yumiko Oishi, Kazuyuki Tobe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Muscle regeneration requires the contribution and communication of various different cell types. Here, Nawaz et al. show that CD206+ macrophages inhibit the secretion of the promyogenic factor follistatin by fibro-adipogenic progenitor cells, impedin
Externí odkaz:
https://doaj.org/article/940fc3d0e8834f71b70e400aa3500e3a
Autor:
Masataka Shikata, Daisuke Chujo, Asako Enkaku, Akiko Takikawa‐Nishida, Hisae Honoki, Shinnosuke Yamada‐Matsukoshi, Maki Nakagawa‐Yokoyama, Miki Kamigishi, Shinya Inagawa, Shiho Fujisaka, Kunimasa Yagi, Kazuto Shibuya, Tsutomu Fujii, Kazuyuki Tobe
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 10, Pp 1685-1694 (2022)
Abstract Aims/Introduction This study aimed to identify the clinical factors affecting postoperative residual pancreatic β‐cell function, as assessed by the C‐peptide index (CPI), and to investigate the association between perioperative CPI and
Externí odkaz:
https://doaj.org/article/42109be6582046b394da4feaeef312f5
Autor:
Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida, Masaaki Uematsu, Kazuki Nakao, Harumi Nakao, Atsu Aiba, Yoji Nagashima, Tetsuya Kubota, Naoto Kubota, Yoshihiko Izumida, Naoya Yahagi, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Shun-ichiro Asahara, Yoshiaki Kido, Hideo Shindou, Michiko Itoh, Yoshihiro Ogawa, Shiro Minami, Yasuo Terauchi, Kazuyuki Tobe, Kohjiro Ueki, Masato Kasuga, Michihiro Matsumoto
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes are interacting comorbidities of obesity, and increased hepatic de novo lipogenesis (DNL), driven by hyperinsulinemia and carbohydrate overload, contributes to their pathogenesis. Fatty aci
Externí odkaz:
https://doaj.org/article/e5ab1c9c4a954f56823c71beefd37326
Autor:
Kunimasa Yagi, Teruhiko Imamura, Hayato Tada, Jianhui Liu, Yukiko Miyamoto, Azusa Ohbatake, Naoko Ito, Masataka Shikata, Asako Enkaku, Akiko Takikawa, Hisae Honoki, Shiho Fujisaka, Daisuke Chujo, Hideki Origasa, Koichiro Kinugawa, Kazuyuki Tobe
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 6, Pp 1052-1061 (2022)
Abstract Aims/Introduction Diastolic cardiac dysfunction in type 2 diabetes (DD2D) is a critical risk of heart failure with preserved ejection fraction. However, there is no established biomarker to detect DD2D. We aimed to investigate the predictive
Externí odkaz:
https://doaj.org/article/6d8b372ab1a14724bd72e9b91811c6a3
Autor:
Minehiko Inomata, Masahiro Matsumoto, Isami Mizushima, Kana Hayashi, Zenta Seto, Kotaro Tokui, Chihiro Taka, Seisuke Okazawa, Kenta Kambara, Shingo Imanishi, Toshiro Miwa, Ryuji Hayashi, Shoko Matsui, Kazuyuki Tobe
Publikováno v:
The Egyptian Journal of Bronchology, Vol 16, Iss 1, Pp 1-7 (2022)
Abstract Purpose We conducted a retrospective analysis of the data of patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) to investigate the associations between clinical factors and the overall survival. M
Externí odkaz:
https://doaj.org/article/8f2fac69bfef4d0bbfcfa51ee111cb99