Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Kazuyoshi Kohu"'
Autor:
Daisuke Douchi, Akihiro Yamamura, Junichi Matsuo, Jung-Won Lee, Napat Nuttonmanit, Yi Hui Melissa Lim, Kazuto Suda, Mitsuhiro Shimura, Sabirah Chen, ShuChin Pang, Kazuyoshi Kohu, Mari Kaneko, Hiroshi Kiyonari, Atsushi Kaneda, Hideyuki Yoshida, Ichiro Taniuchi, Motomi Osato, Henry Yang, Michiaki Unno, Jimmy Bok-Yan So, Khay Guan Yeoh, Linda Shyue Huey Chuang, Suk-Chul Bae, Yoshiaki Ito
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1317-1345 (2022)
Background & Aims: RUNX transcription factors play pivotal roles in embryonic development and neoplasia. We previously identified the single missense mutation R122C in RUNX3 from human gastric cancer. However, how RUNX3R122C mutation disrupts stem ce
Externí odkaz:
https://doaj.org/article/b05baf92b97a4f7b8f43a64fb91a7900
Autor:
Eisaku Ogawa, Tomohiro Edamitsu, Hidetaka Ohmori, Kazuyoshi Kohu, Mineo Kurokawa, Hiroshi Kiyonari, Masanobu Satake, Ryuhei Okuyama
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10039 (2022)
The Runt-related transcription factor (Runx) family has been suggested to play roles in stem cell regulation, tissue development, and oncogenesis in various tissues/organs. In this study, we investigated the possible functions of Runx1 and Runx3 in k
Externí odkaz:
https://doaj.org/article/d15644550b86454f9d9508a7264978be
Autor:
Ken Matsuura, Shizuka Kobayashi, Kohtarou Konno, Miwako Yamasaki, Takahiro Horiuchi, Takao Senda, Tomoatsu Hayashi, Kiyotoshi Satoh, Fumiko Arima-Yoshida, Kei Iwasaki, Lumi Negishi, Naomi Yasui-Shimizu, Kazuyoshi Kohu, Shigenori Kawahara, Yutaka Kirino, Tsutomu Nakamura, Masahiko Watanabe, Tadashi Yamamoto, Toshiya Manabe, Tetsu Akiyama
Publikováno v:
J Neurosci
Signal-induced proliferation-associated 1 (SIPA1)-like 1 (SIPA1L1; also known as SPAR1) has been proposed to regulate synaptic functions that are important in maintaining normal neuronal activities, such as regulating spine growth and synaptic scalin
Autor:
Shigenori Kawahara, Kiyotoshi Satoh, Tomoatsu Hayashi, Yohei Kirino, Tadashi Yamamoto, Kohtarou Konno, Fumiko Arima-Yoshida, Kazuyoshi Kohu, Terumi Horiuchi, Negishi L, Kiyotaka Iwasaki, Masahiko Watanabe, Toshiya Manabe, Shizuka Kobayashi, Michimasa Yamasaki, Takao Senda, Matsuura K, Takahisa Nakamura, Yasui-Shimizu N, Tetsu Akiyama
SIPA1L1 (also known as SPAR1) has been proposed to regulate synaptic functions that are important in maintaining normal neuronal activities, such as regulating spine growth and synaptic scaling, as a component of the postsynaptic density (PSD)-95/N-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::addfc32bd64b3c422055f708df64e8b2
https://doi.org/10.1101/2021.02.12.430872
https://doi.org/10.1101/2021.02.12.430872
Autor:
Supriya Srivastava, Ming Teh, Yi Hui Melissa Lim, Asim Shabbir, Kazuyoshi Kohu, Akihiro Yamamura, Linda Shyue Huey Chuang, Junichi Matsuo, Go Shioi, Shu Chin Pang, Kazuto Suda, Jimmy Bok Yan So, Napat Nuttonmanit, Takaya Abe, Yoshiaki Ito, Sabirah Chen, Mitsuhiro Shimura, Guowei Kim, Khay Guan Yeoh, Michiaki Unno, Daisuke Douchi
Publikováno v:
Gastroenterology. 161(6)
Background & Aims Metaplasia and dysplasia in the corpus are reportedly derived from de-differentiation of chief cells. However, the cellular origin of metaplasia and cancer remained uncertain. Therefore, we investigated whether pepsinogen C (PGC) tr
Autor:
Khine Myint, Kazuyoshi Kohu, Jinmiao Chen, Dede Liana Heng, Makoto Adachi, Sachiko Tsukita, Napat Nuttonmanit, Nur Astiana Mawan, Nicole Yee Shin Lee, Ying Li, Shamaine Wei Ting Ho, Junichi Matsuo, Khay Guan Yeoh, Sabirah Chen, Henry Yang, Atsushi Tamura, Wei Peng Yong, Naing Naing Mon, Hong Kai Lee, Jimmy Bok Yan So, Supriya Srivastava, Daisuke Douchi, Akihiro Yamamura, Patrick Tan, Linda Shyue Huey Chuang, Yoshiaki Ito, Ming Teh
Publikováno v:
Gut
ObjectiveTissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus.DesignWe
Autor:
Yusuke Yamazumi, Oh Sasaki, Yuki Kamoshida, Tetsu Akiyama, Kazuyoshi Kohu, Keishi Fujio, Saki Suyama-Fuchino, Hiroaki Harada, Takeaki Oda
Publikováno v:
Biochemical and biophysical research communications. 519(2)
While most asthma can be treated with steroids, about 10%, called severe asthma, is refractory to steroids. It has recently been shown that in a subgroup of severe asthma cases, neutrophils that infiltrate into the airways play an important role in i
Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair.
Autor:
Junichi Matsuo, Daisuke Douchi, Khine Myint, Naing Naing Mon, Akihiro Yamamura, Kazuyoshi Kohu, Dede Liana Heng, Sabirah Chen, Mawan, Nur Astiana, Napat Nuttonmanit, Ying Li, Srivastava, Supriya, Shamaine Wei Ting Ho, Yee Shin Lee, Nicole, Hong Kai Lee, Makoto Adachi, Atsushi Tamura, Jinmiao Chen, Yang, Henry, Ming Teh
Publikováno v:
Gut; Oct2021, Vol. 70 Issue 10, p1833-1846, 14p
Autor:
Ryo Funayama, Masanobu Satake, Mineo Kurokawa, Grace Min Yi Tan, Mitsuyo Matsumoto, Kazuyoshi Kohu, Kazuhiko Igarashi, Tee Cian Yeow, Keiko Nakayama, Elaheh Movahed, Won Fen Wong, Takeshi Nagashima, Motomi Osato, Chung Yeng Looi
Publikováno v:
Molecular Immunology. 68:223-233
The Runx1 transcription factor cooperates with or antagonizes other transcription factors and plays essential roles in the differentiation and function of T lymphocytes. Previous works showed that Runx1 is expressed in peripheral CD4(+) T cells which
Autor:
Li-Yen Chang, Kazuyoshi Kohu, Tomo Funaki, Chung Yeng Looi, Shunsuke Kon, Won Fen Wong, Masanobu Satake, Elaheh Movahed
Publikováno v:
European Journal of Immunology. 44:894-904
Runx1 transcription factor is a key player in the development and function of T cells. Runx1 transcripts consist of two closely related isoforms (proximal and distal Runx1) whose expressions are regulated by different promoters. Which Runx1 isoform i