Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Kazuyoshi Ikeda"'
Autor:
Tatsuki Akabane, Nobuhiro Suzuki, Kazuyoshi Ikeda, Tomoki Yonezawa, Satoru Nagatoishi, Hiroyoshi Matsumura, Takuya Yoshizawa, Wataru Tsuchiya, Satoshi Kamino, Kouhei Tsumoto, Ken Ishimaru, Etsuko Katoh, Naoki Hirotsu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract An indole-3-acetic acid (IAA)-glucose hydrolase, THOUSAND-GRAIN WEIGHT 6 (TGW6), negatively regulates the grain weight in rice. TGW6 has been used as a target for breeding increased rice yield. Moreover, the activity of TGW6 has been thought
Externí odkaz:
https://doaj.org/article/a27712ed73804e448b10d70a808e541d
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Membrane permeability is an in vitro parameter that represents the apparent permeability (Papp) of a compound, and is a key absorption, distribution, metabolism, and excretion parameter in drug development. Although the Caco-2 cell lines are
Externí odkaz:
https://doaj.org/article/2bcbc21b9dbd471cbd991451510adb17
AI-driven molecular generation of not-patented pharmaceutical compounds using world open patent data
Autor:
Yugo Shimizu, Masateru Ohta, Shoichi Ishida, Kei Terayama, Masanori Osawa, Teruki Honma, Kazuyoshi Ikeda
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-11 (2023)
Abstract Developing compounds with novel structures is important for the production of new drugs. From an intellectual perspective, confirming the patent status of newly developed compounds is essential, particularly for pharmaceutical companies. The
Externí odkaz:
https://doaj.org/article/0b04847734da477a9d6dedc784708b85
Autor:
Kazuyoshi Ikeda, Yuta Maezawa, Tomoki Yonezawa, Yugo Shimizu, Toshiyuki Tashiro, Satoru Kanai, Nobuyoshi Sugaya, Yoshiaki Masuda, Naoko Inoue, Tatsuya Niimi, Keiichi Masuya, Kenji Mizuguchi, Toshio Furuya, Masanori Osawa
Publikováno v:
Frontiers in Chemistry, Vol 10 (2023)
Protein–protein interactions (PPIs) are recognized as important targets in drug discovery. The characteristics of molecules that inhibit PPIs differ from those of small-molecule compounds. We developed a novel chemical library database system (DLiP
Externí odkaz:
https://doaj.org/article/42cbdb75873e4e278b556cd412d3723b
Autor:
Yugo Shimizu, Tomoki Yonezawa, Junichi Sakamoto, Toshio Furuya, Masanori Osawa, Kazuyoshi Ikeda
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Protein–protein interactions (PPIs) are prospective but challenging targets for drug discovery, because screening using traditional small-molecule libraries often fails to identify hits. Recently, we developed a PPI-oriented library compri
Externí odkaz:
https://doaj.org/article/5ad949d62a434e0094fc0a9cd8840561
Autor:
Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada, Masanori Osawa
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1. APETx1 is a 42-residue peptide toxin of s
Externí odkaz:
https://doaj.org/article/fefcd79f84134514b7e6ed26583065d2
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Given the abundant computational resources and the huge amount of data of compound–protein interactions (CPIs), constructing appropriate datasets for learning and evaluating prediction models for CPIs is not always easy. For this study, we have dev
Externí odkaz:
https://doaj.org/article/47b81522629145b78ac64ce9ab9ef074
Autor:
Tsuyoshi Esaki, Kazuyoshi Ikeda
Publikováno v:
Chem-Bio Informatics Journal. 23:1-6
Publikováno v:
Chem-Bio Informatics Journal. 22:46-54
Publikováno v:
Chem-Bio Informatics Journal. 22:38-45