Výsledky vyhledávání - "Kazuyoshi Aso"

Akademický článek

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Autor: Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor a

Externí odkaz: https://doaj.org/article/2885ccbed5fa465f9f9e037a1d7866c1

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Akademický článek

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

Publikováno v: eLife, Vol 6 (2017)

Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for firs

Externí odkaz: https://doaj.org/article/8d68f62670e24975998fadfad88f3954

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Akademický článek

Adipose-Derived Mesenchymal Stem Cells Restore Impaired Mucosal Immune Responses in Aged Mice.

Autor: Kazuyoshi Aso, Akitoshi Tsuruhara, Kentaro Takagaki, Katsuyuki Oki, Megumi Ota, Yasuhiro Nose, Hideki Tanemura, Naoki Urushihata, Jinichi Sasanuma, Masayuki Sano, Atsuyuki Hirano, Rio Aso, Jerry R McGhee, Kohtaro Fujihashi

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148185 (2016)

It has been shown that adipose-derived mesenchymal stem cells (AMSCs) can differentiate into adipocytes, chondrocytes and osteoblasts. Several clinical trials have shown the ability of AMSCs to regenerate these differentiated cell types. Age-associat

Externí odkaz: https://doaj.org/article/55e04b3493be45beac84f01c34588d93

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Akademický článek

Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)

The previously published version of this Article contained errors in Fig. 6. In panel h the units of the x axis were incorrectly given as mM and should have been given as µM. Also, the IC50s for RU.365, RU.332 and RU.521 within panel h were incorrec

Externí odkaz: https://doaj.org/article/920c5aa0d55044bb8e7799f3d44a9730

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Akademický článek

Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses.

Autor: Yoshiko Fukuyama, Daisuke Tokuhara, Shinichi Sekine, Kazuyoshi Aso, Kosuke Kataoka, Julia Davydova, Masato Yamamoto, Rebekah S Gilbert, Yuka Tokuhara, Keiko Fujihashi, Jun Kunisawa, Yoshikazu Yuki, Hiroshi Kiyono, Jerry R McGhee, Kohtaro Fujihashi

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60453 (2013)

We assessed the role of CCR5(+)/CCR6(+)/CD11b(+)/CD11c(+) dendritic cells (DCs) for induction of ovalbumin (OVA)-specific antibody (Ab) responses following mucosal immunization. Mice given nasal OVA plus an adenovirus expressing Flt3 ligand (Ad-FL) s

Externí odkaz: https://doaj.org/article/e67de8f7dd71445d98a0c9996ed96c13

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Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome

Publikováno v: Journal of Medicinal Chemistry. 64:6262-6272

Treatment of tuberculosis (TB) currently takes at least 6 months. Latent Mycobacterium tuberculosis (Mtb) is phenotypically tolerant to most anti-TB drugs. A key hypothesis is that drugs that kill nonreplicating (NR) Mtb may shorten treatment when us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49ac426b4c19d0fdaa3f695a2619ad2e
https://doi.org/10.1021/acs.jmedchem.1c00296

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A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors

Autor: Rui Liang, Daisuke Tomita, Yusuke Sasaki, John Ginn, Mayako Michino, David J. Huggins, Leigh Baxt, Stacia Kargman, Maaz Shahid, Kazuyoshi Aso, Mark Duggan, Andrew W. Stamford, Elisa DeStanchina, Nigel Liverton, Peter T. Meinke, Michael A. Foley, Richard E. Phillips

Publikováno v: ACS Med Chem Lett

[Image: see text] Aberrant gene-silencing through dysregulation of polycomb protein activity has emerged as an important oncogenic mechanism in cancer, implicating polycomb proteins as important therapeutic targets. Recently, an inhibitor targeting E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fe1f32f4d2fdd6317d49a02ab86ed4
https://pubmed.ncbi.nlm.nih.gov/35300079

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A chemical strategy toward novel brain-penetrant EZH2 inhibitors

Autor: Mark Duggan, Kazuyoshi Aso, Sasaki Y, Nigel J. Liverton, Liang R, Phillips Re, Stacia Kargman, Mayako Michino, Daisuke Tomita, Shahid M, Peter T. Meinke, Leigh Baxt, DeStanchina E, David J. Huggins, Michael Foley, Andrew Stamford, John Ginn

Aberrant gene-silencing through dysregulation of polycomb protein activity has emerged as an important oncogenic mechanism in cancer, implicating polycomb proteins as important therapeutic targets. Recently, an inhibitor targeting EZH2, the methyltra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7d1041e7fd09af897b5fbd7996cd485
https://doi.org/10.1101/2021.06.10.447852

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