Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Kazuyoshi Aso"'
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Annie Leung, Yi J. Liu, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Mayako Michino, Takafumi Yukawa, Sevil Chelebieva, Patrick K. Tumwebaze, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Philip J. Rosenthal, Roland A. Cooper, Nigel Liverton, Michael Foley, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 66:1484-1508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::396cefbba4bbff5c41d426f4caafe461
https://doi.org/10.1021/acs.jmedchem.2c01651
https://doi.org/10.1021/acs.jmedchem.2c01651
Autor:
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor a
Externí odkaz:
https://doaj.org/article/2885ccbed5fa465f9f9e037a1d7866c1
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Yi J. Liu, Annie Leung, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Mayako Michino, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:9350-9375
With over 200 million cases and close to half a million deaths each year, malaria is a threat to global health, particularly in developing countries.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b58c6b8b4be75e0e7350e808c708fd6
https://doi.org/10.1021/acs.jmedchem.2c00611
https://doi.org/10.1021/acs.jmedchem.2c00611
Autor:
Jonathan B Steinman, Cristina C Santarossa, Rand M Miller, Lola S Yu, Anna S Serpinskaya, Hideki Furukawa, Sachie Morimoto, Yuta Tanaka, Mitsuyoshi Nishitani, Moriteru Asano, Ruta Zalyte, Alison E Ondrus, Alex G Johnson, Fan Ye, Maxence V Nachury, Yoshiyuki Fukase, Kazuyoshi Aso, Michael A Foley, Vladimir I Gelfand, James K Chen, Andrew P Carter, Tarun M Kapoor
Publikováno v:
eLife, Vol 6 (2017)
Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for firs
Externí odkaz:
https://doaj.org/article/8d68f62670e24975998fadfad88f3954
Autor:
Shoshanna C. Kahne, Tierra Ouellette, Priya Saha, Huilin Li, Michael Foley, Toshihiro Imaeda, Kazuyoshi Aso, Ryoma Hara, K. Heran Darwin, Carl Nathan, Masanori Kawasaki, Akinori Toita, Wenhu Zhan, Francesca Moraca, Gang Lin, Jeremie Vendome, Takafumi Yukawa, John Ginn, Xiuju Jiang, Mayako Michino, Kenjiro Sato, Peter T. Meinke, Hao Zhang, Kristin Burns-Huang, Rei Okamoto, Tzu-Tshin Wong, Hao-Chi Hsu
Publikováno v:
Journal of Medicinal Chemistry. 64:6262-6272
Treatment of tuberculosis (TB) currently takes at least 6 months. Latent Mycobacterium tuberculosis (Mtb) is phenotypically tolerant to most anti-TB drugs. A key hypothesis is that drugs that kill nonreplicating (NR) Mtb may shorten treatment when us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ac426b4c19d0fdaa3f695a2619ad2e
https://doi.org/10.1021/acs.jmedchem.1c00296
https://doi.org/10.1021/acs.jmedchem.1c00296
Autor:
Kazuyoshi Aso, Akitoshi Tsuruhara, Kentaro Takagaki, Katsuyuki Oki, Megumi Ota, Yasuhiro Nose, Hideki Tanemura, Naoki Urushihata, Jinichi Sasanuma, Masayuki Sano, Atsuyuki Hirano, Rio Aso, Jerry R McGhee, Kohtaro Fujihashi
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148185 (2016)
It has been shown that adipose-derived mesenchymal stem cells (AMSCs) can differentiate into adipocytes, chondrocytes and osteoblasts. Several clinical trials have shown the ability of AMSCs to regenerate these differentiated cell types. Age-associat
Externí odkaz:
https://doaj.org/article/55e04b3493be45beac84f01c34588d93
Autor:
Rui Liang, Daisuke Tomita, Yusuke Sasaki, John Ginn, Mayako Michino, David J. Huggins, Leigh Baxt, Stacia Kargman, Maaz Shahid, Kazuyoshi Aso, Mark Duggan, Andrew W. Stamford, Elisa DeStanchina, Nigel Liverton, Peter T. Meinke, Michael A. Foley, Richard E. Phillips
Publikováno v:
ACS Med Chem Lett
[Image: see text] Aberrant gene-silencing through dysregulation of polycomb protein activity has emerged as an important oncogenic mechanism in cancer, implicating polycomb proteins as important therapeutic targets. Recently, an inhibitor targeting E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fe1f32f4d2fdd6317d49a02ab86ed4
https://pubmed.ncbi.nlm.nih.gov/35300079
https://pubmed.ncbi.nlm.nih.gov/35300079
Autor:
Mark Duggan, Kazuyoshi Aso, Sasaki Y, Nigel J. Liverton, Liang R, Phillips Re, Stacia Kargman, Mayako Michino, Daisuke Tomita, Shahid M, Peter T. Meinke, Leigh Baxt, DeStanchina E, David J. Huggins, Michael Foley, Andrew Stamford, John Ginn
Aberrant gene-silencing through dysregulation of polycomb protein activity has emerged as an important oncogenic mechanism in cancer, implicating polycomb proteins as important therapeutic targets. Recently, an inhibitor targeting EZH2, the methyltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7d1041e7fd09af897b5fbd7996cd485
https://doi.org/10.1101/2021.06.10.447852
https://doi.org/10.1101/2021.06.10.447852
Autor:
Trevor Morgan, Kazuyoshi Aso, Huilin Li, Wenhu Zhan, Gang Lin, Tierra Ouellette, Peter T. Meinke, Carl Nathan, Manoj K. Ramjee, Adrian G. Wright, Hao-Chi Hsu, Toshihiro Imaeda, Mayako Michino, Kenjiro Sato, Kristin Burns-Huang, Ryoma Hara, Michael Foley, Rei Okamoto
Publikováno v:
Journal of Medicinal Chemistry. 62:9246-9253
Proteasomes of pathogenic microbes have become attractive targets for anti-infectives. Coevolving with its human host, Mycobacterium tuberculosis (Mtb) has developed mechanisms to resist host-impos...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04bac3c504e9295cab53b06b52750141
https://doi.org/10.1021/acs.jmedchem.9b01187
https://doi.org/10.1021/acs.jmedchem.9b01187
Autor:
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
The previously published version of this Article contained errors in Fig. 6. In panel h the units of the x axis were incorrectly given as mM and should have been given as µM. Also, the IC50s for RU.365, RU.332 and RU.521 within panel h were incorrec
Externí odkaz:
https://doaj.org/article/920c5aa0d55044bb8e7799f3d44a9730