Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kazuyoshi, Kirimura"'
Autor:
Shinji, Takai 1, Denan, Jin 1, Kazuyoshi, Kirimura 2, Junko, Ikeda 2, Masato, Sakaguchi 1, Kimiye, Baba 3, Tadashi, Fujita 2, Mizuo, Miyazaki 1
Publikováno v:
In Japanese Journal of Pharmacology 1999 80(1):89-92
Autor:
Mizuo Miyazaki, Katsuhiro Yoshikawa, Mika Nakabayashi, Shinji Takai, Kanta Kishi, Yoshiki Mino, Denan Jin, Kazuyoshi Kirimura, Michiko Muramatsu
Publikováno v:
Hypertension Research. 28:457-464
Vascular smooth muscle cells in spontaneously hypertensive rats (SHR) express angiotensin II-forming chymase (rat vascular chymase [RVCH]), which may contribute to blood pressure regulation. In this study, we studied whether chymase-dependent angiote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6424f8f4f432640abcf22e096d1720e6
https://doi.org/10.1291/hypres.28.457
https://doi.org/10.1291/hypres.28.457
Autor:
Yoshiki Mino, Katsuhiro Yoshikawa, Kazuyoshi Kirimura, Denan Jin, Mizuo Miyazaki, Shinji Takai, Michiko Muramatsu
Publikováno v:
Hypertension Research. 28:593-600
Although the lipophilicities of the various angiotensin II receptor blockers (ARBs) are very different, the relationship between lipophilicity and the protective effect against vascular remodeling is unclear. In this study, we compared the protective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12269fe5f93ac6a3b64594cb009971e5
https://doi.org/10.1291/hypres.28.593
https://doi.org/10.1291/hypres.28.593
Autor:
Michiko Muramatsu, Denan Jin, Mizuo Miyazaki, Masato Sakaguchi, Kazuyoshi Kirimura, Hiroshi Sakonjo, Kenji Ishii, Shinji Takai
Publikováno v:
Hypertension Research. 27:517-522
Angiotensin II receptor blockers could prevent the development of atherosclerosis beyond reducing blood pressure in monkeys fed a high-cholesterol diet. However, it has been unclear whether hypotensive effects improve atherosclerosis in primates. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6ed5d9efacd2ef95c1a0cb4ce3adec
https://doi.org/10.1291/hypres.27.517
https://doi.org/10.1291/hypres.27.517
Publikováno v:
Clinica Chimica Acta. 305:191-195
We studied the angiotensin II-forming pathways in extracts from human and rat vascular tissues. In the extract from human artery, angiotensin I mainly converted to two products, angiotensin-(1-9) and angiotensin II, while in the extract from rat arte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76664c5c719873b60bc67593cedb6127
https://doi.org/10.1016/s0009-8981(01)00379-5
https://doi.org/10.1016/s0009-8981(01)00379-5
Autor:
Mizuo Miyazaki, Denan Jin, Masato Sakaguchi, Atsushi Yuda, Shinji Takai, Kazuyoshi Kirimura, Masayoshi Nishimoto
Publikováno v:
European Journal of Pharmacology. 411:301-304
Cilostazol prevents neointimal formation, but its mechanism has remained unclear. We investigated whether intimal formation in dog grafted veins is suppressed by cilostazol, and studied the effect of cilostazol on angiotensin II-forming enzymes. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799aef1e59e2fcb25931f5ab0c60e10a
https://doi.org/10.1016/s0014-2999(00)00864-5
https://doi.org/10.1016/s0014-2999(00)00864-5
Autor:
Tadashi Fujita, Junko Ikeda, Denan Jin, Masato Sakaguchi, Mizuo Miyazaki, Kimiye Baba, Shinji Takai, Kazuyoshi Kirimura
Publikováno v:
Japanese Journal of Pharmacology. 80:89-92
We investigated whether a lipoxygenase inhibitor, panaxynol, affected the vascular contraction induced by angiotensin (Ang) II and the mean arterial pressure in spontaneously hypertensive rats (SHR). Panaxynol suppressed dose-dependently the contract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d3abee08ed06686d0c47a6372b447c
https://doi.org/10.1254/jjp.80.89
https://doi.org/10.1254/jjp.80.89
Autor:
Mizuo Miyazaki, Shinji Takai, Hiroshi Sakonjo, Maki Kimura, Kazuyoshi Kirimura, Denan Jin, Kazuhiko Tanaka
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 30(12)
The angiotensin receptor blocker (ARB) telmisartan is a partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). Typical PPARgamma agonists suppress the gene expression of angiotensin-converting enzyme (ACE) in vascular tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0967eaa98487fe0348365522f9d62548
https://pubmed.ncbi.nlm.nih.gov/18344629
https://pubmed.ncbi.nlm.nih.gov/18344629
Autor:
Hiroshi Sakonjo, Mizuo Miyazaki, Michiko Muramatsu, Kazuyoshi Kirimura, Shinji Takai, Denan Jin
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 46(5)
Aldosterone may be involved in the pathogenesis of atherosclerosis. We investigated the effect of eplerenone, a selective mineralocorticoid receptor blocker, on atherosclerosis in monkeys fed a high-cholesterol diet. Monkeys fed a high-cholesterol di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0576c7f0123ebdb1a7fd0d833d068685
https://pubmed.ncbi.nlm.nih.gov/16434723
https://pubmed.ncbi.nlm.nih.gov/16434723
Publikováno v:
Japanese journal of pharmacology. 86(1)
We investigated the effects of a novel chymase inhibitor, BCEAB (4-[1-[[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid). The IC50 value of BCEAB for purified human chymase was 5.4 nM, whereas BCEAB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69c7169fe5755d00ce67c63364b325a
https://pubmed.ncbi.nlm.nih.gov/11430464
https://pubmed.ncbi.nlm.nih.gov/11430464