Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kazuyo Kakoi"'
Autor:
Toshiyuki Takeuchi, Tadahiro Nambu, Jessica Huck Sappal, Kazumasa Miyamoto, Akifumi Kogame, Kurt Eng, Yukie Kashima, Kazuyo Kakoi, Shun-Ichiro Kageyama, Karuppiah Kannan, Hiroshi Haeno, Saomi Murai, Akihiro Ohashi, Jie Yu, Masamitsu Gotou, Osamu Kurasawa, Huifeng Niu, Kenichi Iwai
Publikováno v:
Science Advances
Potential combination partners of a CDC7 inhibitor TAK-931 were identified to guide its clinical development strategy.
Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA replication. We developed a highly speci
Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA replication. We developed a highly speci
Autor:
Yukiko Yamamoto, Kazuyo Kakoi, Yoshinori Satomi, Hiroyuki Sumi, Satoru Nishizawa, Kazunobu Aoyama, Megumi Hirayama, Ikuo Miyahisa, Hironobu Maezaki, Kohei Honda, Hideo Araki, Takahito Hara, Ryuuichi Nishigaki, Masako Sasaki, Satoshi Kitazawa, Imamura Keisuke, Yoshihiko Satoh
Publikováno v:
European Journal of Pharmacology. 807:21-31
Most cancer cells are characterized by elevated lipid biosynthesis. The rapid proliferation of cancer cells requires de novo synthesis of fatty acids. Stearoyl-CoA desaturase-1 (SCD1), a key enzyme for lipogenesis, is overexpressed in various types o
Autor:
Shuhei Yao, Hideyuki Oki, Bi-Ching Sang, Shunichirou Tsutsumi, Tsuneaki Tottori, Takashi Imada, Juran Kato, Sei Yoshida, Kazuyo Kakoi, Tomoyasu Ishikawa, Masanori Okaniwa, Akihiko Sumita, Masaaki Hirose, Tohru Miyazaki, Masato Yabuki, Takeo Arita, Jason Yano, Kathleen Aertgeerts, Youko Hayashi, Terufumi Takagi, Tomohiro Ohashi, Tomohiro Kawamoto
Publikováno v:
Journal of medicinal chemistry. 55(7)
To develop RAF/VEGFR2 inhibitors that bind to the inactive DFG-out conformation, we conducted structure-based drug design using the X-ray cocrystal structures of BRAF, starting from an imidazo[1,2-b]pyridazine derivative. We designed various [5,6]-fu
Autor:
Kenichi Iwai1, Tadahiro Nambu1, Yukie Kashima2,3,4, Jie Yu5, Kurt Eng5, Kazumasa Miyamoto6, Kazuyo Kakoi1, Masamitsu Gotou6, Toshiyuki Takeuchi7, Akifumi Kogame7, Sappal, Jessica5, Saomi Murai8, Hiroshi Haeno2, Shun-Ichiro Kageyama3, Osamu Kurasawa1, Huifeng Niu9, Kannan, Karuppiah5,10, Ohashi, Akihiro1,2,5
Publikováno v:
Science Advances. 5/19/2021, Vol. 7 Issue 21, p1-14. 14p.