Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Kazuya Takenouchi"'
Autor:
Hidekazu Watanabe, Akiko Takeuchi, Kenichiro Takagi, Midori Takimoto-Kamimura, Hiroshi Saitoh, Shinji Kakuda, Kazuya Takenouchi
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 148:27-30
We synthesized and evaluated novel vitamin D 3 derivatives with cyanoalkyl side chain at C-2 position on the basis of our previous research for 2α side chain which bears nitrogen atom-containing functional group. Through a study of X-ray co-crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b2c538c7a5d3696a1bf28193487fe7
https://doi.org/10.1016/j.jsbmb.2014.12.004
https://doi.org/10.1016/j.jsbmb.2014.12.004
Autor:
Qingzhi Gao, Koichi Ueno, Hiroko Tanaka, Seiichi Ishizuka, Minoru Furuya, Yasuhiro Takano, Katsushi Takahashi, Kenji Manabe, Masayasu Tabe, Atsushi Hazato, Kazuya Takenouchi, Hiroaki Mitsuhashi, Manabu Chokki
Publikováno v:
Steroids. 77:1535-1542
While searching for vitamin D(3) analogues which inhibit neutrophil recruitment in the lung without elevating plasma calcium level, we found that (5Z,7E)-(1S,3R)-20(R)-[(5E)-(2S)-2-hydroxy-2-methyl-cyclopentanone-5-ylidene]methyl-9,10-secopregna-5,7,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c6358fc5b6ab645347f81d438d7e3a
https://doi.org/10.1016/j.steroids.2012.09.008
https://doi.org/10.1016/j.steroids.2012.09.008
Autor:
Ken Ichiro Takagi, Kazuya Takenouchi, Toshiyuki Sakaki, Kaori Yasuda, Daisuke Sawada, Tai C. Chen, Yuya Tsukuda, Hiroshi Saito, G. Satyanarayana Reddy, Atsushi Kittaka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:1343-1346
A previous report has demonstrated the existence of a C4-hydroxylated vitamin D(2) metabolite in serum of rats treated with pharmacological doses of vitamin D(2). However, the biological significance and metabolic fate of this metabolite have not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5407b1d78b51f718a74f9479d42c2182
https://doi.org/10.1248/cpb.c12-00526
https://doi.org/10.1248/cpb.c12-00526
Autor:
Masashi Takano, Hiroshi Saito, Seiichi Ishizuka, Nozomi Saito, Eiji Ochiai, Atsushi Kittaka, Shinji Kakuda, Kanako Shindo, Kyohei Horie, Midori Takimoto-Kamimura, Ken Ichiro Takagi, Go Kumagai, Daisuke Sawada, Kazuya Takenouchi
Publikováno v:
Organic Letters. 13:2852-2855
C15-Substituted 1α,25-dihydroxyvitamin D(3) analogs were synthesized for the first time to investigate the effects of the modified CD-ring on biological activity concerning the agonistic positioning of helix-3 and helix-12 of the vitamin D receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f988d030c8cebf6797d3750a5c8e6a
https://doi.org/10.1021/ol200828s
https://doi.org/10.1021/ol200828s
Autor:
Hiroshi Saito, Eiji Ochiai, Seiichi Ishizuka, Nozomi Saito, Atsushi Kittaka, Ken Ichiro Takagi, Yuya Tsukuda, Tomoyuki Katayama, Daisuke Sawada, Kazuya Takenouchi
Publikováno v:
Tetrahedron. 66:5407-5423
2α- and 2β-Substituted analogs of 14-epi-previtamin D3 were synthesized and isolated after thermal isomerization of 14-epi-vitamin D3 triene at 80 °C. The VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93b67ab2fa7092ddc38c6b0cfc60cfc
https://doi.org/10.1016/j.tet.2010.05.028
https://doi.org/10.1016/j.tet.2010.05.028
Autor:
Eiji Ochiai, Seiichi Ishizuka, Nozomi Saito, Daisuke Sawada, Atsushi Kittaka, Kazuya Takenouchi, Tomoyuki Katayama, Masashi Takano, Yuya Tsukuda, Ken Ichiro Takagi, Hiroshi Saito
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5397-5400
We synthesized and isolated 2 alpha-substituted analogs of 14-epi-previtamin D3 after thermal isomerization at 80 degrees C for the first time. The VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells were evaluated,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9b0e62d5ff848ad8b19ec2a0f77d60
https://doi.org/10.1016/j.bmcl.2009.07.112
https://doi.org/10.1016/j.bmcl.2009.07.112
Autor:
Junichi Namekawa, Seiichi Ishizuka, Fumito Uneuchi, Kazuya Takenouchi, Yuko Kato-Nakamura, Kaori Cho, Kazuo Nagasawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4287-4290
Structure–activity relationship studies on 1α,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), antagonists of vitamin D, were conducted, focusing on the substituents of the phenyl group. One of the derivatives (23S,25S)-DLAM-1P-3,5(OEt)2, showed pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8321689ff6e3ce0e6bcaa3ba50d834
https://doi.org/10.1016/j.bmcl.2008.06.095
https://doi.org/10.1016/j.bmcl.2008.06.095
Autor:
Miki Matsuo, Asami Hasegawa, Masashi Takano, Hiroshi Saito, Shinji Kakuda, Kenichiro Takagi, Eiji Ochiai, Kyohei Horie, Midori Takimoto-Kamimura, Kazuya Takenouchi, et al. et al.
Publikováno v:
ChemInform. 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7ecf9954ce7da3ce36bfe10a3d6da61
https://doi.org/10.1002/chin.201509332
https://doi.org/10.1002/chin.201509332
Autor:
Atsushi Kittaka, Midori Takimoto-Kamimura, Hiroshi Saito, Junichi Namekawa, Kazuya Takenouchi, Manami Masuda, Seiichi Ishizuka, Nozomi Saito
Publikováno v:
Synthesis. 2005:2533-2543
Novel vitamin D receptor antagonists, 24,24-ethanovitamin D 3 -26,23-lactones 6 and 7 and their 2a-functionalized analogues 6a-c and 7a-c were synthesized and their biological activities were evaluated. The triene structure of vitamin D 3 was constru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6063d307a14be70ad1d0fae263575caa
https://doi.org/10.1055/s-2005-872075
https://doi.org/10.1055/s-2005-872075
Autor:
Hiroshi Saito, Atsushi Kittaka, Kenichiro Takagi, Daisuke Sawada, Yuya Tsukuda, Kazuya Takenouchi, Midori Takimoto-Kamimura, Shinji Kakuda, Eiji Ochiai
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 136:27-29
Recently, we evaluated a novel skeleton in the vitamin D family, 14-epi-1α,25(OH)2-19-nortachysterol, and discovered its unique binding configuration in the human vitamin D receptor (VDR) with the C5,6- and C7,8-s-trans triene configuration. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6d64f24fa4a7289cdb3bc678fc9f69
https://doi.org/10.1016/j.jsbmb.2012.11.014
https://doi.org/10.1016/j.jsbmb.2012.11.014