Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Kazuya KUSAMA"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The fusion of mononuclear trophoblasts into multinucleate syncytiotrophoblasts is the critical event in the process of syncytialization, and its dysregulation can lead to pregnancy complications, notably hypertensive disorders of pregnancy (
Externí odkaz:
https://doaj.org/article/5fb1e78471de4335a083b9c6fcbb5d8d
Publikováno v:
The Journal of Reproduction and Development, Vol 69, Iss 5, Pp 246-253 (2023)
Intrauterine extracellular vesicles (EVs) are involved in establishing proper conceptus-endometrial communication, which is essential for conceptus implantation and subsequent successful placentation. Despite several studies on intrauterine EVs, the
Externí odkaz:
https://doaj.org/article/344a3d699e0d43859b727efc102a44f0
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 259-266 (2022)
Uterine leiomyosarcoma is an aggressive soft tissue tumor. Stathmin, a phosphoprotein that modulates microtubule dynamics, is highly expressed in many malignancies including leiomyosarcoma. The microtubule-depolymerizing agent eribulin has been recen
Externí odkaz:
https://doaj.org/article/22ec3201c253415f9d8adb80b39c5e4e
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 267-274 (2022)
The pathogenesis of hypertensive disorder of pregnancy (HDP), which affects about 10% of pregnant women, is still incompletely understood. Our previous study showed that endoplasmic reticulum (ER) stress influences high-temperature requirement A seri
Externí odkaz:
https://doaj.org/article/661b0f57eb7d4142a7e3254510f02246
Autor:
Atsuya Tsuru, Mikihiro Yoshie, Ryo Yonekawa, Junya Kojima, Mana Azumi, Kazuya Kusama, Hirotaka Nishi, Kazuhiro Tamura
Publikováno v:
Reproductive Medicine, Vol 3, Iss 2, Pp 189-200 (2022)
Human endometrial stromal cells (ESCs) differentiate into decidual cells for embryo implantation during the mid-secretory phase of the menstrual cycle. Decidualization is characterized by enhanced production of insulin-like growth factor-binding prot
Externí odkaz:
https://doaj.org/article/3ce5958daf0349d390ef438a92cd559a
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1680 (2023)
Viviparity is made possible by the placenta, a structure acquired relatively recently in the evolutionary history of eutherian mammals. Compared to oviparity, it increases the survival rate of the fetus, owing to the eutherian placenta. Questions suc
Externí odkaz:
https://doaj.org/article/bca7cd878c404ba89e0b8da1a3339b56
Autor:
Rulan Bai, Kazuya Kusama, Yuta Matsuno, Hanako Bai, Toshihiro Sakurai, Koji Kimura, Kazuhiko Imakawa
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Prostaglandin E2 (PGE2) is considered as a luteoprotective factor, influencing the corpus luteum during the early pregnant period in the bovine species. Cyclic AMP (cAMP) is activated in response to PGE2 and plays a role in many physiological process
Externí odkaz:
https://doaj.org/article/af08e79502144807ab9f41de349a1a84
Autor:
Mikihiro Yoshie, Kensuke Ohishi, Gen Ishikawa, Atsuya Tsuru, Kazuya Kusama, Mana Azumi, Kazuhiro Tamura
Publikováno v:
Reproductive Medicine and Biology, Vol 22, Iss 1, Pp n/a-n/a (2023)
Abstract Purpose Extravillous trophoblasts (EVTs) invade the endometrium to establish a fetomaternal interaction during pregnancy. Epidermal growth factor (EGF) and heparin‐binding EGF‐like growth factor (HB‐EGF) stimulate EVT invasion by bindi
Externí odkaz:
https://doaj.org/article/b307b5b2ac40435e9468042afcd2065e
Autor:
Kazuya Kusama, Ayaka Satoyoshi, Mana Azumi, Mikihiro Yoshie, Junya Kojima, Yumi Mizuno, Masanori Ono, Hirotaka Nishi, Takeshi Kajihara, Kazuhiro Tamura
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Endometriosis is characterized by the presence of inflamed and fibrotic endometrial tissue outside the uterine cavity. Previously, we found decreased SERPINA1 (alpha-1 antitrypsin) expression in endometriosis-like lesions in a mouse model of endometr
Externí odkaz:
https://doaj.org/article/ec8aa575c7554b398e1ce4d74fa682ed
Autor:
Nagaki Ohnuki, Tomoko Kobayashi, Misaki Matsuo, Kohei Nishikaku, Kazuya Kusama, Yasushi Torii, Yasuko Inagaki, Masatoshi Hori, Kazuhiko Imakawa, Yorifumi Satou
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Bovine leukemia virus (BLV) is an oncogenic retrovirus which induces malignant lymphoma termed enzootic bovine leukosis (EBL) after a long incubation period. Insertion sites of the BLV proviral genome as well as the associations between dise
Externí odkaz:
https://doaj.org/article/061573a7de70457ba4db65d47273971d