Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kazuya Honbou"'
Autor:
Kazuya Honbou, Naoyuki Masuda, Ryushi Seo, Yasushi Amano, Masaki Tomishima, Mayako Yamazaki, Ichiji Namatame, Ayaka Chino, Takuma Mihara, Wataru Hamaguchi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:286-294
In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug discovery (FBDD). The pyrazolopyridine derivative 2 was found to be a fragment hit compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a18a22e367934bba8d6a598acca777
https://doi.org/10.1248/cpb.c17-00836
https://doi.org/10.1248/cpb.c17-00836
Autor:
Ayaka, Chino, Ryushi, Seo, Yasushi, Amano, Ichiji, Namatame, Wataru, Hamaguchi, Kazuya, Honbou, Takuma, Mihara, Mayako, Yamazaki, Masaki, Tomishima, Naoyuki, Masuda
Publikováno v:
Chemicalpharmaceutical bulletin. 66(3)
In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug discovery (FBDD). The pyrazolopyridine derivative 2 was found to be a fragment hit compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8b27b965dc573e4579c43a5e1a0de32
https://pubmed.ncbi.nlm.nih.gov/29491261
https://pubmed.ncbi.nlm.nih.gov/29491261
Autor:
Eiji Kurosaki, Masanao Sanagi, Hiroyuki Okumura, Hiroaki Masuzaki, Katsuhiko Gato, Kazuya Honbou, Akira Suwa, Takako Yonemoto, Tomohiko Yamaguchi, Yuko Kawasaki, Yuichi Tomura, Hirotoshi Kakuta, Tatsuya Niimi, Masaya Orita
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:10-20
A proportion of angiotensin II type 1 receptor blockers (ARBs) improves glucose dyshomeostasis and insulin resistance in a clinical setting. Of these ARBs, telmisartan has the unique property of being a partial agonist for peroxisome proliferator-act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321fb2363212fdae6a21d1505fcdfa4d
https://doi.org/10.1124/jpet.113.211722
https://doi.org/10.1124/jpet.113.211722
Autor:
Kazuya Honbou, Shigetoshi Kikuchi, Takuma Mihara, Naoyuki Masuda, Mai Isomura, Wataru Hamaguchi, Satoshi Miyamoto, Yasushi Amano, Toshihiro Watanabe
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:7612-7623
A novel class of phosphodiesterase 10A (PDE10A) inhibitors with reduced CYP1A2 inhibition were designed and synthesized starting from 2-{[(1-phenyl-1H-benzimidazol-6-yl)oxy]methyl}quinoline (1). Introduction of an isopropyl group at the 2-position an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e908df17c5b4b2b78ad83d26491a362d
https://doi.org/10.1016/j.bmc.2013.10.035
https://doi.org/10.1016/j.bmc.2013.10.035
Publikováno v:
Journal of Innate Immunity. 1:543-555
The phagocyte NADPH oxidase, crucial for innate immunity, is dormant in resting cells, but becomes activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. In activation of the oxidase, the multidomain protein p67pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c707ff81d989ef2d811e37274878f3a
https://doi.org/10.1159/000235656
https://doi.org/10.1159/000235656
Publikováno v:
Nihon Kessho Gakkaishi. 47:390-395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::407be519b1c3ca276a947c798d484665
https://doi.org/10.5940/jcrsj.47.390
https://doi.org/10.5940/jcrsj.47.390
Autor:
Hiroshi Fushiki, Yasushi Amano, Hiroyuki Moriguchi, Shigetoshi Kikuchi, Takuma Mihara, Kouji Hattori, Yasuhiro Shiina, Satoshi Miyamoto, Wataru Hamaguchi, Yoshihiro Murakami, Kazuya Honbou, Naoyuki Masuda
Publikováno v:
Bioorganicmedicinal chemistry. 23(2)
A novel class of phosphodiesterase 10A inhibitors with potent PDE10A inhibitory activity and reduced CYP3A4 inhibition was designed and synthesized starting from 2-[4-({[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]quinoline (1). Repla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505bcf6589fd1e15b0a734dfef837c5f
https://pubmed.ncbi.nlm.nih.gov/25515954
https://pubmed.ncbi.nlm.nih.gov/25515954
Autor:
Ayaka Chino, Takuma Mihara, Yasushi Amano, Mayako Yamazaki, Masaki Tomishima, Kazuya Honbou, Naoyuki Masuda
Publikováno v:
Bioorganicmedicinal chemistry. 22(13)
In this study, we report the identification of potent benzimidazoles as PDE10A inhibitors. We first identified imidazopyridine 1 as a high-throughput screening hit compound from an in-house library. Next, optimization of the imidazopyridine moiety to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb9fd0db54d047f38d82e11103e1c36
https://pubmed.ncbi.nlm.nih.gov/24837154
https://pubmed.ncbi.nlm.nih.gov/24837154
Autor:
Fuyuhiko Inagaki, Kazuya Honbou, Yoshinori Ohsumi, Nobuo N. Noda, Yasuyoshi Sakai, Kuninori Suzuki, Yasunori Watanabe
Publikováno v:
Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun.. :571-573
Saccharomyces cerevisiae alpha-mannosidase (Ams1) is a cargo protein that is transported to the vacuole by the cytoplasm-to-vacuole targeting (Cvt) pathway during conditions of growth and by autophagy during conditions of starvation. After transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a632c6b7da50828d976f93a225ef7ee
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100724285
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100724285
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 62:1018-1020
p40(phox) is a cytosolic component of the phagocyte NADPH oxidase, which is responsible for production of the superoxide that kills invasive microorganisms. Full-length p40(phox) was expressed in Escherichia coli, purified and crystallized by the sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca10049f041a654f55c3e9ee22e72c00
https://doi.org/10.1107/s1744309106036256
https://doi.org/10.1107/s1744309106036256