Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Kazuya, Miyashita"'
Autor:
Takao Kimura, Kazuya Miyashita, Isamu Fukamachi, Kumiko Fukamachi, Kazumi Ogura, Erina Yokoyama, Katsuhiko Tsunekawa, Takumi Nagasawa, Michael Ploug, Ye Yang, Wenxin Song, Stephen G. Young, Anne P. Beigneux, Katsuyuki Nakajima, Masami Murakami
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 4, Pp 100532- (2024)
To support in vivo and in vitro studies of intravascular triglyceride metabolism in mice, we created rat monoclonal antibodies (mAbs) against mouse LPL. Two mAbs, mAbs 23A1 and 31A5, were used to develop a sandwich ELISA for mouse LPL. The detection
Externí odkaz:
https://doaj.org/article/7bb09355127f4c74a78df72318b9d2fc
Publikováno v:
Practical Laboratory Medicine, Vol 37, Iss , Pp e00337- (2023)
To investigate the regulation of soluble very low-density lipoprotein receptor (sVLDL-R), which is cleaved mostly from the extracellular domain of VLDL-R II, we generated two rat monoclonal antibodies (mAbs) against human sVLDL-R, and used them to de
Externí odkaz:
https://doaj.org/article/2fd0023dbc0f4a2e891a1a19cd0e504b
Autor:
Mingli Li, Lu Yang, Anthony K. N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen‐Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J. R. Bishop, Chun‐Wei Chen
Publikováno v:
Advanced Science, Vol 10, Iss 17, Pp n/a-n/a (2023)
Abstract Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS). However, the epigenetic networks underlying the maintenance of oncogenic signaling and therapeutic response remain unclear. Using a series of epigenetics
Externí odkaz:
https://doaj.org/article/d8eb48a7527744de8eb5ea7136bf0bee
Autor:
Ayumu Taniguchi, Kazuya Miyashita, Shota Fukae, Ryo Tanaka, Mami Nishida, Tomomi Kitayama, Yuya Ouchi, Takashi Shimbo, Shigeaki Nakazawa, Kazuaki Yamanaka, Ryoichi Imamura, Katsuto Tamai, Norio Nonomura
Publikováno v:
Biochemistry and Biophysics Reports, Vol 33, Iss , Pp 101433- (2023)
Ischemia-reperfusion injury (IRI) causes massive tissue damage. Renal IRI is the most common type of acute renal injury, and the defects caused by it may progress to chronic kidney disease (CKD). Rodent models of renal IRI, with various patterns, hav
Externí odkaz:
https://doaj.org/article/9e5817ea575e4af7972e106a272812cd
Autor:
Tomoaki Kunitsu, Mariko Harada-Shiba, Tomomi Sato, Kazuo Nonomura, Takao Kimura, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami
Publikováno v:
Allergology International, Vol 71, Iss 4, Pp 555-557 (2022)
Externí odkaz:
https://doaj.org/article/53ab14629b134e39bca9175907ce08b2
Autor:
Sachiko Kobayashi, Shunbun Kita, Daisuke Okuzaki, Yuya Fujishima, Michio Otsuki, Hisashi Kato, Yasuko Nishizawa, Kazuya Miyashita, Chieko Yokoyama, Atsunori Fukuhara, Eiichi Morii, Iichiro Shimomura
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105252- (2022)
Summary: Currently, no mouse models manifest calcification and thrombus formation, which is frequently associated with human atherosclerosis. We demonstrated that lack of Favine/CCDC3 in apoE knockout mice accelerated atherosclerosis accompanied by l
Externí odkaz:
https://doaj.org/article/5f890c2fec2f41df8bde2ae9965d59fe
Autor:
Lu Yang, Anthony K. N. Chan, Kazuya Miyashita, Christopher D. Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T. Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A. Armstrong, Chun-Wei Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.
Externí odkaz:
https://doaj.org/article/ddb7b59f991343969e3fce23606cbf5c
Autor:
Yen-Ting Ho, Takashi Shimbo, Edward Wijaya, Tomomi Kitayama, Satoshi Takaki, Kentaro Ikegami, Kazuya Miyashita, Yuya Ouchi, Eiichi Takaki, Ryoma Yamamoto, Yasufumi Kaneda, Katsuto Tamai
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 547-566 (2021)
Background & Aims: Proper resolution of inflammation is essential to maintaining homeostasis, which is important as a dysregulated inflammatory response has adverse consequences, even being regarded as a hallmark of cancer. However, our picture of dy
Externí odkaz:
https://doaj.org/article/23fc3a8d6ed64cb48e110a16004fa035
Autor:
Wenxin Song, Anne P. Beigneux, Anne-Marie L. Winther, Kristian K. Kristensen, Anne L. Grønnemose, Ye Yang, Yiping Tu, Priscilla Munguia, Jazmin Morales, Hyesoo Jung, Pieter J. de Jong, Cris J. Jung, Kazuya Miyashita, Takao Kimura, Katsuyuki Nakajima, Masami Murakami, Gabriel Birrane, Haibo Jiang, Peter Tontonoz, Michael Ploug, Loren G. Fong, Stephen G. Young
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
GPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial spaces (where it is secreted by myocytes and adipocytes) and transports it across ECs to its site of action in the capillary lumen. GPIHBP1’s 3-fin
Externí odkaz:
https://doaj.org/article/4780a6e489eb4eb2947f3a57c5c18c7c
Autor:
Kazuya Miyashita, Jens Lutz, Lisa C. Hudgins, Dana Toib, Ambika P. Ashraf, Wenxin Song, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1365-1376 (2020)
Some cases of chylomicronemia are caused by autoantibodies against glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1), an endothelial cell protein that shuttles LPL to the capillary lumen. GPIHBP1 autoantibodies prevent binding and
Externí odkaz:
https://doaj.org/article/04b8654d456140aca80ec46a6659c392