Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Kazuya, Hasegawa"'
Autor:
Takashi Yazawa, Yugo Watanabe, Yuko Yokohama, Yoshitaka Imamichi, Kazuya Hasegawa, Ke-ichi Nakajima, Takeshi Kitano, Takanori Ida, Takahiro Sato, Mohammad Sayful Islam, Akihiro Umezawa, Satoru Takahashi, Yasuhito Kato, Sharmin Jahan, Jun-ichi Kawabe
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
3β-Hydroxysteroid dehydrogenases (3β-HSDs) catalyze the oxidative conversion of delta (5)-ene-3-beta-hydroxy steroids and ketosteroids. Human 3β-HSD type 2 (HSD3B2) is predominantly expressed in gonadal and adrenal steroidogenic cells for producin
Externí odkaz:
https://doaj.org/article/8b8186365c784724afed80dc9e31ad03
Autor:
Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai, Hiromi Ogata-Aoki, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Nobutoki Takamune, Naoki Kishimoto, Shin-ichiro Hattori, Debananda Das, Yukari Uemura, Yosuke Shimizu, Manabu Aoki, Kazuya Hasegawa, Satoshi Suzuki, Akie Nishiyama, Junji Saruwatari, Yukiko Shimizu, Yoshikazu Sukenaga, Yuki Takamatsu, Kiyoto Tsuchiya, Kenji Maeda, Kazuhisa Yoshimura, Shun Iida, Seiya Ozono, Tadaki Suzuki, Tadashi Okamura, Shogo Misumi, Yoshihiro Kawaoka, Hirokazu Tamamura, Hiroaki Mitsuya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Effective antivirals are critical for combatting SARS-CoV-2 infections. Here, the authors develop two orally available small molecules, which specifically inhibit the activity of the SARS-CoV-2 main protease and potently block the infectivity and rep
Externí odkaz:
https://doaj.org/article/0a9319e808d143a0af10cb89193b1a4f
Autor:
Shoun Taguchi, Satomi Niwa, Hoang-Anh Dao, Yoshihiro Tanaka, Ryota Takeda, Shuya Fukai, Kazuya Hasegawa, Kazuki Takeda
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)
Crystal structures and quantum mechanical calculations reveal the interaction and photoisomerized conformation of the retinal chromophore in the K intermediate of bacteriorhodopsin (bR), giving insights into light-driven bR proton pumping.
Externí odkaz:
https://doaj.org/article/7ab55cd4dd4d482bacba119889e6eb3a
Autor:
Yuko Makino, Chihiro Oe, Kazuya Iwama, Satoshi Suzuki, Akie Nishiyama, Kazuya Hasegawa, Haruka Okuda, Kazushige Hirata, Mariko Ueno, Kumi Kawaji, Mina Sasano, Emiko Usui, Toshiaki Hosaka, Yukako Yabuki, Mikako Shirouzu, Makoto Katsumi, Kazutaka Murayama, Hironori Hayashi, Eiichi N. Kodama
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Structural and biophysical studies of the inhibition of bacterial serine hydroxymethyltransferase (SHMT) by a human SHMT inhibitor used for cancer therapy, (+)-SHIN-1, identify SHMT as a potent antibacterial target.
Externí odkaz:
https://doaj.org/article/efb597c97e904da9b72ba16baed8e329
Autor:
Shin-ichiro Hattori, Bulut, Haydar, Hironori Hayashi, Naoki Kishimoto, Nobutoki Takamune, Kazuya Hasegawa, Yuri Furusawa, Seiya Yamayoshi, Kazutaka Murayama, Hirokazu Tamamura, Mi Li, Wlodawer, Alexander, Yoshihiro Kawaoka, Shogo Misumi, Hiroaki Mitsuya
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 9/10/2024, Vol. 121 Issue 37, p1-10, 22p
Autor:
Jacob R. Boos, Hanna N. Jandrain, Emi Hagiuda, Alexander T. Taguchi, Kazuya Hasegawa, Bailey L. Fedun, Sarah J. Taylor, Sofhia M. Elad, Sarah E. Faber, Takashi Kumasaka, Toshio Iwasaki, Werner J. Geldenhuys
Publikováno v:
Advances in Redox Research, Vol 6, Iss , Pp 100048- (2022)
CISD-1/mitoNEET is an evolutionarily conserved outer mitochondrial membrane [2Fe-2S] protein that regulates mitochondrial function and morphology. The [2Fe-2S] clusters are redox reactive and shown to mediate oxidative stress in vitro and in vivo. Ho
Externí odkaz:
https://doaj.org/article/63ce18420c8049339dc30f096fa06230
Publikováno v:
Plants, Vol 12, Iss 8, p 1717 (2023)
Pectin modification and degradation are vital for plant development, although the underlying mechanisms are still not well understood. Furthermore, reports on the function of pectin in early pollen development are limited. We generated OsPME-FOX rice
Externí odkaz:
https://doaj.org/article/12bdda53546f444a9fb7b5293bac63e7
Autor:
Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when co
Externí odkaz:
https://doaj.org/article/86d3e81f7e794c15baedd9ad9a968412
Autor:
Kiyofumi Takaba, Yang Tai, Haruhiko Eki, Hoang-Anh Dao, Yuya Hanazono, Kazuya Hasegawa, Kunio Miki, Kazuki Takeda
Publikováno v:
IUCrJ, Vol 6, Iss 3, Pp 387-400 (2019)
Green fluorescent protein (GFP) is a light-emitting protein that does not require a prosthetic group for its fluorescent activity. As such, GFP has become indispensable as a molecular tool in molecular biology. Nonetheless, there has been no subatomi
Externí odkaz:
https://doaj.org/article/3343b3cab2734fafbb4835771cec2ba6
Autor:
Asron Sani, Kazuya Hasegawa, Yuya Yamaguchi, Pharkphoom Panichayupakaranant, Yutthana Pengjam
Publikováno v:
Phytomedicine Plus, Vol 1, Iss 1, Pp 100012- (2021)
Background: Sarcopenia is a disease of progressive loss of muscle mass due to the imbalance of protein synthesis and proteolysis, and tends to emerge with ageing. Currently its treatment consists of non-drug therapies and drug therapies, but some med
Externí odkaz:
https://doaj.org/article/2b46a78370ad410d976198958c22287a