Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Kazutoyo Miura"'
Autor:
Kazutoyo Miura, Bingbing Deng, Ragavan Varadharajan Suresh, Yonas T. Gebremicale, Luwen Zhou, Thao P. Pham, Kyle Roche, Ababacar Diouf, Jonathan F. Lovell, Jean-Philippe Julien, Carole A. Long
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Malaria remains a global health problem, and the standard membrane feeding assay (SMFA) is a key functional assay for development of new interventions to stop malaria transmission from human to mosquito. For SMFA, media with ~ 10% of human s
Externí odkaz:
https://doaj.org/article/32f6c09562ee4cb4bb5405b3c67bfa21
Autor:
Camila H. Coelho, Susanna Marquez, Bergeline C. Nguemwo Tentokam, Anne D. Berhe, Kazutoyo Miura, Vishal N. Rao, Carole A. Long, Ogobara K. Doumbo, Issaka Sagara, Sara Healy, Steven H. Kleinstein, Patrick E. Duffy
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-7 (2024)
Abstract The impact of adjuvants on malaria vaccine-induced antibody repertoire is poorly understood. Here, we characterize the impact of two adjuvants, Alhydrogel® and AS01, on antibody clonotype diversity, binding and function, post malaria vaccin
Externí odkaz:
https://doaj.org/article/8c0cc61ee491450e8fc4e1ebcb75ad6e
Autor:
Barnabas G. Williams, Lloyd D. W. King, David Pulido, Doris Quinkert, Amelia M. Lias, Sarah E. Silk, Robert J. Ragotte, Hannah Davies, Jordan R. Barrett, Kirsty McHugh, Cassandra A. Rigby, Daniel G. W. Alanine, Lea Barfod, Michael W. Shea, Li An Cowley, Rebecca A. Dabbs, David J. Pattinson, Alexander D. Douglas, Oliver R. Lyth, Joseph J. Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M. Christen, Amy R. Noe, Randall S. MacGill, C. Richter King, Ashley J. Birkett, Lorraine A. Soisson, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeri
Externí odkaz:
https://doaj.org/article/c0357f954cd04ff984155d03439a386e
Autor:
Jonathan F. Lovell, Kazutoyo Miura, Yeong Ok Baik, Chankyu Lee, Jeong-Yoon Lee, Young-Shin Park, Ingi Hong, Jung Hyuk Lee, Taewoo Kim, Sang Hwan Seo, Jae-Ouk Kim, Manki Song, Chung-Jong Kim, Jae-Ki Choi, Jieun Kim, Eun Ju Choo, Jung-Hyun Choi
Publikováno v:
International Journal of Infectious Diseases, Vol 138, Iss , Pp 73-80 (2024)
Objective: EuCorVac-19 (ECV-19), an adjuvanted liposome-displayed receptor binding domain (RBD) COVID-19 vaccine, previously reported interim Phase 2 trial results showing induction of neutralizing antibodies 3 weeks after prime-boost immunization. T
Externí odkaz:
https://doaj.org/article/92e258add5c642e19060a10330ea19f8
Autor:
Sean Yanik, Varsha Venkatesh, Michelle L. Parker, Raghavendran Ramaswamy, Ababacar Diouf, Deepti Sarkar, Kazutoyo Miura, Carole A. Long, Martin J. Boulanger, Prakash Srinivasan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Invasion of human erythrocytes by Plasmodium falciparum (Pf) merozoites relies on the interaction between two parasite proteins: apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2). While antibodies to AMA1 provide limited pro
Externí odkaz:
https://doaj.org/article/9187528e96e24a5396c3a092c3c046b1
Autor:
Palak N. Patel, Thayne H. Dickey, Ababacar Diouf, Nichole D. Salinas, Holly McAleese, Tarik Ouahes, Carole A. Long, Kazutoyo Miura, Lynn E. Lambert, Niraj H. Tolia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Apical membrane antigen 1 (AMA1) is a key malaria vaccine candidate and target of neutralizing antibodies. AMA1 binds to a loop in rhoptry neck protein 2 (RON2L) to form the moving junction during parasite invasion of host cells, and this co
Externí odkaz:
https://doaj.org/article/e25790efa50d468795dd8e573113c770
Autor:
Nichole D. Salinas, Rui Ma, Thayne H. Dickey, Holly McAleese, Tarik Ouahes, Carole A. Long, Kazutoyo Miura, Lynn E. Lambert, Niraj H. Tolia
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Malaria transmission-blocking vaccines (TBVs) reduce disease transmission by breaking the continuous cycle of infection between the human host and the mosquito vector. Domain 1 (D1) of Pfs230 is a leading TBV candidate and comprises the majo
Externí odkaz:
https://doaj.org/article/2ab6d2c8491e429d86c474230614ad0e
Autor:
Niharika Shukla, Wai Kwan Tang, Camila H. Coelho, Carole A. Long, Sara A. Healy, Issaka Sagara, Kazutoyo Miura, Patrick E. Duffy, Niraj H. Tolia
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Pfs25 is a leading antigen for a malaria transmission-blocking vaccine and shows moderate transmission-blocking activity and induction of rapidly decreasing antibody titers in clinical trials. A comprehensive definition of all transmission-r
Externí odkaz:
https://doaj.org/article/2b2a9cc4c3a14a22b8a2355e8bb81d9f
Autor:
Kazutoyo Miura
Publikováno v:
Vaccines, Vol 12, Iss 6, p 586 (2024)
While two Plasmodium falciparum circumsporozoite protein-based pre-erythrocytic vaccines (PEV), RTS,S and R21, have been approved by the WHO, no blood-stage vaccine (BSV) or transmission-blocking vaccine (TBV) has reached a phase 3 trial. One of the
Externí odkaz:
https://doaj.org/article/1a15651f5380435eac4bb950cb417bb2
Autor:
Nichole D. Salinas, Rui Ma, Holly McAleese, Tarik Ouahes, Carole A. Long, Kazutoyo Miura, Lynn E. Lambert, Niraj H. Tolia
Publikováno v:
Vaccines, Vol 12, Iss 5, p 546 (2024)
Malaria is caused by eukaryotic protozoan parasites of the genus Plasmodium. There are 249 million new cases and 608,000 deaths annually, and new interventions are desperately needed. Malaria vaccines can be divided into three categories: liver stage
Externí odkaz:
https://doaj.org/article/26f63ef025694a5f811a1f546e35c75f