Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Kazutoshi YAMAMOTO"'
Autor:
Olga Kim, Zach Sergi, Guangyang Yu, Kazutoshi Yamamoto, Martha Quezado, Zied Abdullaev, Danel R. Crooks, Shun Kishimoto, Qi Li, Peng Lu, Burchelle Blackman, Thorkell Andresson, Xiaolin Wu, Bao Tran, Jun S. Wei, Wei Zhang, Meili Zhang, Hua Song, Javed Khan, Murali C. Krishna, Jeffrey R. Brender, Jing Wu
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Malignant transformation (MT) is commonly seen in IDH-mutant gliomas. There has been a growing research interest in revealing its underlying mechanisms and intervening prior to MT at the early stages of the transforming process. Here we esta
Externí odkaz:
https://doaj.org/article/4b329e13fa87456ea2628bbe4d0bfe40
Autor:
Tomohiro Seki, Yu Saida, Shun Kishimoto, Jisook Lee, Yasunori Otowa, Kazutoshi Yamamoto, Gadisetti VR Chandramouli, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, Jeffery R. Brender
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 30, Iss , Pp 100793- (2022)
Purpose: PEGylated human hyaluronidase (PEGPH20) enzymatically depletes hyaluronan, an important component of the extracellular matrix, increasing the delivery of therapeutic molecules. Combinations of chemotherapy and PEGPH20, however, have been uns
Externí odkaz:
https://doaj.org/article/f1585e36c7944ba19758e09803a3851d
Autor:
Kazutoshi Yamamoto, Ana Opina, Deepak Sail, Burchelle Blackman, Keita Saito, Jeffrey R. Brender, Ronja M. Malinowski, Tomohiro Seki, Nobu Oshima, Daniel R. Crooks, Shun Kishimoto, Yu Saida, Yasunori Otowa, Peter L. Choyke, Jan H. Ardenkjær-Larsen, James B. Mitchell, W. Marston Linehan, Rolf E. Swenson, Murali C. Krishna
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Drastic sensitivity enhancement of dynamic nuclear polarization is becoming an increasingly critical methodology to monitor real-time metabolic and physiological information in chemistry, biochemistry, and biomedicine. However, the limited n
Externí odkaz:
https://doaj.org/article/bad8b5268826453db750b84fe20d286f
Autor:
Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1798-1810.e4 (2020)
Summary: The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to dete
Externí odkaz:
https://doaj.org/article/b3f7874afa484caba2d1087fcf914a16
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The dynamic protein-protein and protein-ligand interactions of integral bitopic membrane proteins with a single membrane-spanning helix play a plethora of vital roles in the cellular processes associated with human health and diseases, inclu
Externí odkaz:
https://doaj.org/article/d6fc88d914294a2a968b2df38f418938
Autor:
Shun Kishimoto, Jeffrey R Brender, Daniel R Crooks, Shingo Matsumoto, Tomohiro Seki, Nobu Oshima, Hellmut Merkle, Penghui Lin, Galen Reed, Albert P Chen, Jan Henrik Ardenkjaer-Larsen, Jeeva Munasinghe, Keita Saito, Kazutoshi Yamamoto, Peter L Choyke, James Mitchell, Andrew N Lane, Teresa WM Fan, W Marston Linehan, Murali C Krishna
Publikováno v:
eLife, Vol 8 (2019)
Metabolic differences among and within tumors can be an important determinant in cancer treatment outcome. However, methods for determining these differences non-invasively in vivo is lacking. Using pancreatic ductal adenocarcinoma as a model, we dem
Externí odkaz:
https://doaj.org/article/55e2be4d50894222ab3e33462c3754bc
Autor:
Isaiah Adelabu, Jessica Ettedgui, Sameer M. Joshi, Shiraz Nantogma, Md Raduanul H. Chowdhury, Stephen McBride, Thomas Theis, Venkata R. Sabbasani, Mushti Chandrasekhar, Deepak Sail, Kazutoshi Yamamoto, Rolf E. Swenson, Murali C. Krishna, Boyd M. Goodson, Eduard Y. Chekmenev
Publikováno v:
Analytical Chemistry. 94:13422-13431
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d08c130eab6955fc7a22e8ebb9ad604e
https://doi.org/10.1021/acs.analchem.2c02160
https://doi.org/10.1021/acs.analchem.2c02160
Publikováno v:
Development, Growth & Differentiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6cf026f91bd24e829915063ac355c65
https://doi.org/10.1111/dgd.12868
https://doi.org/10.1111/dgd.12868
Autor:
Yasunori Otowa, Shun Kishimoto, Yu Saida, Kota Yamashita, Kazutoshi Yamamoto, Gadisetti VR Chandramouli, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, Jeffery R. Brender
Publikováno v:
Antioxidants & Redox Signaling.
AimsPancreatic ductal adenocarcinomas (PDACs) form hypovascular and hypoxic tumors which are difficult to treat with current chemotherapy regimens. Gemcitabine (GEM) is often used as a first line treatment for PDACs, but has issues with chemoresistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069ab1e34afc6f99d3b3cbd141c156bf
https://doi.org/10.1089/ars.2022.0118
https://doi.org/10.1089/ars.2022.0118
Autor:
Shun Kishimoto, Nallathamby Devasahayam, Gadisetti VR Chandramouli, Ramachandran Murugesan, Yasunori Otowa, Kota Yamashita, Kazutoshi Yamamoto, Jeffrey R Brender, Murali C Krishna
PurposeIn this study, we compared two triarylmethyl (TAM) spin probes, Ox071 and Ox063 for their efficacy in measuring tissue oxygen concentration by R2*-based oximetry in hypoxic and normoxic conditions.MethodsThe R2* dependence with spin probe and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c5c5c19a1efd9d1fbd86a753b91b61
https://doi.org/10.1101/2023.05.18.541366
https://doi.org/10.1101/2023.05.18.541366
