Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Autor: Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

Publikováno v: eLife, Vol 12 (2024)

Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicate

Externí odkaz: https://doaj.org/article/15de117935204a21a8487997042e8094

177. Alterations in NRG/ErbB and NMDAR Signaling May Contribute to Brain Region-Specific Dopamine Dysbalance in Schizophrenia

Autor: Kazutoshi Nakazawa

Overall Abstract: The dopamine (DA) hypothesis of schizophrenia is among the most enduring biological theories in psychiatry, and it has received some substantial modifications. For example, a major revision of the theory was made over 2 decades ago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051c9ad761f6790476d054a7365e2dea
https://europepmc.org/articles/PMC5475704/

Kinetic Study of Human β- 1,4-Galactosyltrasgerase Expressed in E.coli1

Autor: Kiyoshi Furukawa, Hisashi Narimatsu, Kazutoshi Nakazawa, Akira Kobata

Publikováno v: The Journal of Biochemistry. 113:747-753

Recombinant beta-1,4-galactosyltransferase which synthesizes the Gal beta 1-->4GlcNAc group of glycoprotein sugar chains was obtained as a soluble form from Escherichia coli by transfection of the human cDNA lacking the transmembrane segment. Kinetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60ebd97a5fc4ba266feafdea303021f0
https://doi.org/10.1093/oxfordjournals.jbchem.a124115

The conjunctive stimuli that cause long-term desensitization also predominantly induce c-Fos and Jun-B in cerebellar Purkinje cells

Autor: Kazutoshi Nakazawa, Yusaku Nakabeppu, Tetsuo Yamamori, Laddawan Karachot

Publikováno v: Scopus-Elsevier

Expression of immediate early genes (IEGs) was examined following long-term desensitization of cerebellar Purkinje cells. This form of desensitization, which may underlie synaptic long-term depression (LTD), was evoked by co-administration of alpha-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5540f082f6fbbaa53d90008e3ca0db14
https://pubmed.ncbi.nlm.nih.gov/7693017

Phosphorylation of AMPA-type glutamate receptors in Purkinje cells detected by phosphorylation state-specific antibody

Autor: Sumiko Mikawa, Kiyoshi Nokihara, Takushi Tadakuma, Ryoji Yano, Masao Ito, Kazutoshi Nakazawa

Publikováno v: Neuroscience Research Supplements. 19:S250

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfadf61950003eefd0f0c9aa31a2ab1d
https://doi.org/10.1016/0921-8696(94)92974-2