Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kazutoshi Horie"'
Autor:
Yumiko Matsuo, Seijiro Hara, Takushi Kanazu, Hiroyuki Shimaoka, Kenji Miyata, Hiroyuki Kusuhara, Shingo Sakamoto, Noboru Okamura, Takahiko Baba, Kazutoshi Horie, Yuichi Sugiyama, Kohji Nomura
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:610-618
Methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) is a novel inhibitor of the ileal apical sodium-dependent bile acid transporter (ASBT/SLC10A2) developed for the treatment of hypercholesterolemia. The
Autor:
Takayoshi Yoshikawa, Masahiro Sakagami, Kazutoshi Horie, Kazuyoshi Masuda, Koichiro Hirano, Hiroshi Hamana, Mitsuru Notoya
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:1275-1280
We have previously found that carboxymethylpullulan (CMPul) conjugated with sialyl Lewis X (Neu5Acalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc-, 2-3SLex) preferentially accumulates in the lymph nodes and spleen. In the present study, we investigated the str
Publikováno v:
Pharmaceutical Research. 20:130-134
Purpose. To evaluate the ability of a water-in-oil (W/O) emulsion containing ovalbumin (OVA), a model antigen, to induce oral tolerance and to elucidate the mechanism for the induction of oral tolerance by the emulsion system. Methods. A W/O emulsion
Publikováno v:
Pharmaceutical Research. 20:161-168
Purpose. The purpose of this study was to isolate Caco-2 subclones that express high levels of multidrug resistance protein (MDR1) and to characterize their kinetics and affinity parameters for MDR1 substrate/inhibitors. Methods. The subclones were s
Publikováno v:
Pharmaceutical Research. 19:765-772
Purpose. To investigate whether Madin-Darby canine kidney cells transfected with the human MRP2 gene (MDCK-MRP2) are a good model of the human intestinal mucosa.
Publikováno v:
Microbiology and Immunology. 46:55-58
Several liposomes containing ovalbumin (OVA), a model antigen, with different lipid compositions were prepared in order to evaluate their ability to induce oral tolerance. Oral administration of these liposomal OVAs induced suppression of the prolife
Autor:
Masahiro Sakagami, Koichiro Hirano, Kazutoshi Horie, Hideo Nogusa, Hiroshi Hamana, Kazuyoshi Masuda
Publikováno v:
Pharmaceutical Research. 18:217-223
Purpose. To demonstrate the potential of carboxymethylpullulan (CMPul) as a carrier for targeting immune tissues, and to find whether immune tissues could be set as the target of an immunosuppressant to treat autoimmune diseases. Methods. The biodist
Publikováno v:
Microbiology and Immunology. 44:401-404
Sialyl Lewis X (SLe(x)), an E-selectin ligand, was conjugated with carboxymethylpullulan (CMPul) and the disposition characteristics of this conjugate after intravenous administration were investigated using mice with ear edema. The concentration of
Autor:
Masahiro Sakagami, Teruomi Ito, Kohji Hanasaki, Kentaro Kuramochi, Hiroshi Hamana, Kazutoshi Horie
Publikováno v:
Pharmaceutical Research. 16:314-320
Purpose. E-selectin is a cell adhesion molecule that is specifically expressed in the inflammatory vascular endothelium in response to cytokines such as IL-1β and TNF-α, and interacts with specific ligands containing sialyl Lewis X (Neu5Acα2-3Gal
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:1237-1245
Sialyl Lewis X (1) is known to be a ligand of the cell adhesion molecule E-selectin. We have synthesized several biantennary glycoside-terminated ligands mimicking sialyl Lewis X (1), and evaluated their binding activity to E-selectin using HL-60 cel