Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kazuto Sakoori"'
Autor:
Yuto Okuno, Kazuto Sakoori, Kyoko Matsuyama, Miwako Yamasaki, Masahiko Watanabe, Kouichi Hashimoto, Takaki Watanabe, Masanobu Kano
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Functionally mature neural circuits are shaped during postnatal development by eliminating redundant synapses formed during the perinatal period. In the cerebellum of neonatal rodents, each Purkinje cell (PC) receives synaptic inputs from multiple (m
Externí odkaz:
https://doaj.org/article/1c216c745c894a65a754695e7ac14f1a
Autor:
Misato Ichise, Kazuto Sakoori, Kei-ichi Katayama, Naoko Morimura, Kazuyuki Yamada, Hiroki Ozawa, Hayato Matsunaga, Minoru Hatayama, Jun Aruga
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
The striatum is involved in action selection, and its disturbance can cause movement disorders. Here, we show that leucine-rich repeats and transmembrane domain 2 (Lrtm2) controls protein sorting in striatal projection systems, and its deficiency cau
Externí odkaz:
https://doaj.org/article/fa4b4d5bba87434b9ad26127ce23e552
Autor:
Hiroaki Sacai, Kazuto Sakoori, Kohtarou Konno, Kenichiro Nagahama, Honoka Suzuki, Takaki Watanabe, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
CNTNAP2 or AHI1 are autism-associated genes. Here the authors show using knockdown of the genes that this results in reduced excitatory synaptic transmission in layer 2/3 pyramidal neurons in the prefrontal cortex and is associated with impaired soci
Externí odkaz:
https://doaj.org/article/6153503acaf74b829d5d8cc968432771
Autor:
Takanobu Nakazawa, Ryota Hashimoto, Kazuto Sakoori, Yuki Sugaya, Asami Tanimura, Yuki Hashimotodani, Kazutaka Ohi, Hidenaga Yamamori, Yuka Yasuda, Satomi Umeda-Yano, Yuji Kiyama, Kohtarou Konno, Takeshi Inoue, Kazumasa Yokoyama, Takafumi Inoue, Shusuke Numata, Tohru Ohnuma, Nakao Iwata, Norio Ozaki, Hitoshi Hashimoto, Masahiko Watanabe, Toshiya Manabe, Tadashi Yamamoto, Masatoshi Takeda, Masanobu Kano
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schi
Externí odkaz:
https://doaj.org/article/76c7f59a209646a0ada889e8e6621f22
Autor:
Takanobu Nakazawa, Ryota Hashimoto, Kazuto Sakoori, Yuki Sugaya, Asami Tanimura, Yuki Hashimotodani, Kazutaka Ohi, Hidenaga Yamamori, Yuka Yasuda, Satomi Umeda-Yano, Yuji Kiyama, Kohtarou Konno, Takeshi Inoue, Kazumasa Yokoyama, Takafumi Inoue, Shusuke Numata, Tohru Ohnuma, Nakao Iwata, Norio Ozaki, Hitoshi Hashimoto, Masahiko Watanabe, Toshiya Manabe, Tadashi Yamamoto, Masatoshi Takeda, Masanobu Kano
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 7: Article number:10594 (2016); Published: 03 February 2016; Updated: 20 April 2016 Previous work by Rosário et al. 2007 and Schuster et al. 2015 describing the role of ARHGAP33 in regulating dendrite and dendritic spine develo
Externí odkaz:
https://doaj.org/article/b90caf57ff39460bacbf43e98e3dd195
Autor:
Noriko Takashima, Yuri S Odaka, Kazuto Sakoori, Takumi Akagi, Tsutomu Hashikawa, Naoko Morimura, Kazuyuki Yamada, Jun Aruga
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22716 (2011)
Recent genetic linkage analysis has shown that LRRTM1 (Leucine rich repeat transmembrane neuronal 1) is associated with schizophrenia. Here, we characterized Lrrtm1 knockout mice behaviorally and morphologically. Systematic behavioral analysis reveal
Externí odkaz:
https://doaj.org/article/b80744b17e514e2ea3cb028ab770d8f6
Autor:
Kazuto Sakoori, Hiroaki Sacai, Honoka Suzuki, Naofumi Uesaka, Masanobu Kano, Takaki Watanabe, Kohtarou Konno, Kenichiro Nagahama, Masahiko Watanabe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Autism spectrum disorder (ASD) is thought to result from deviation from normal development of neural circuits and synaptic function. Many genes with mutation in ASD patients have been identified. Here we report that two molecules associated with ASD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feeb03ecd9ed6d5908720dbca3dbabfd
http://link.springer.com/article/10.1038/s41467-020-18861-3
http://link.springer.com/article/10.1038/s41467-020-18861-3
Autor:
Michinori Koebis, Atsu Aiba, Masanobu Kano, Naofumi Uesaka, Keita Kawaji, Yusuke Kishi, Yukiko Gotoh, Takaki Watanabe, Kenichiro Nagahama, Kazuki Nakao, Kazuto Sakoori
Publikováno v:
Cell reports. 32(11)
SETD1A encodes a histone methyltransferase whose de novo mutations are identified in schizophrenia (SCZ) patients and confer a large increase in disease risk. Here, we generate Setd1a mutant mice carrying the frameshift mutation that closely mimics a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e9ae92c63edc1344917f43ad594e79
https://pubmed.ncbi.nlm.nih.gov/32937141
https://pubmed.ncbi.nlm.nih.gov/32937141
Autor:
Jun Aruga, Kazuto Sakoori, Naoko Morimura, Miyuki Kabayama, Veravej G. Ornthanalai, Maya Ota, Kazuyuki Yamada, Niall P. Murphy, Kei-ichi Katayama
Publikováno v:
Journal of Neuroscience. 33:12940-12953
Monoamine oxidase A (MAO-A), the catabolic enzyme of norepinephrine and serotonin, plays a critical role in emotional and social behavior. However, the control and impact of endogenous MAO-A levels in the brain remains unknown. Here we show that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7212664594b1e447c34081bbf3a440
https://doi.org/10.1523/jneurosci.5717-12.2013
https://doi.org/10.1523/jneurosci.5717-12.2013
Autor:
Takanobu Nakazawa, Kazumasa Yokoyama, Yuka Yasuda, Asami Tanimura, Tohru Ohnuma, Hidenaga Yamamori, Takeshi Inoue, Yuji Kiyama, Masatoshi Takeda, Masahiko Watanabe, Hitoshi Hashimoto, Satomi Umeda-Yano, Kazutaka Ohi, Shusuke Numata, Nakao Iwata, Norio Ozaki, Kazuto Sakoori, Tadashi Yamamoto, Toshiya Manabe, Kohtarou Konno, Ryota Hashimoto, Yuki Sugaya, Yuki Hashimotodani, Takafumi Inoue, Masanobu Kano
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Intracellular trafficking of receptor proteins is essential for neurons to detect various extracellular factors during the formation and refinement of neural circuits. However, the precise mechanisms underlying the trafficking of neurotrophin recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bacb06f13e9437ec34601d4431d6f9
http://europepmc.org/articles/PMC4843005
http://europepmc.org/articles/PMC4843005