Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Kazuto, Yasuda"'
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
Vitamin D3 (VD3) induces intestinal CYP3A that metabolizes orally administered anti-leukemic chemotherapeutic substrates dexamethasone (DEX) and dasatinib potentially causing a vitamin-drug interaction. To determine the impact of VD3 status on system
Externí odkaz:
https://doaj.org/article/70d4271398e1490ea4a69f7b7d98a340
Autor:
Samit Ganguly, David Finkelstein, Timothy I Shaw, Ryan D Michalek, Kimberly M Zorn, Sean Ekins, Kazuto Yasuda, Yu Fukuda, John D Schuetz, Kamalika Mukherjee, Erin G Schuetz
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253852 (2021)
Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and hepatic drug clearance. The systemic impact of Bcrp and Pgp ablation on metabolic homeosta
Externí odkaz:
https://doaj.org/article/b18f9e558107487fa2603259aa77bcbd
Akademický článek
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Autor:
Monique A. Payton, Kavya Annu, Erin G. Schuetz, Kazuto Yasuda, Brittany Cooper, Julia L. Hurwitz, Cynthia Cline, Samit Ganguly, Laura J. Janke, Kamalika Mukherjee, Sherri L. Surman, Andrea Pesch
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
The effects of vitamin A and/or vitamin D deficiency were studied in an Arf−/− BCR-ABL acute lymphoblastic leukemia murine model. Vitamin D sufficient mice died earlier (p = 0.003) compared to vitamin D deficient (VDD) mice. Vitamin A deficient (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bc3b2e73677f9b6bbac56cce9d0093
https://doi.org/10.1038/s41598-020-59101-4
https://doi.org/10.1038/s41598-020-59101-4
Autor:
Ryan D. Michalek, Samit Ganguly, David Finkelstein, Yu Fukuda, Sean Ekins, Kimberly M. Zorn, John D. Schuetz, Timothy I. Shaw, Kamalika Mukherjee, Erin G. Schuetz, Kazuto Yasuda
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253852 (2021)
PLoS ONE
PLoS ONE
Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and hepatic drug clearance. The systemic impact of Bcrp and Pgp ablation on metabolic homeosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f856f32db4e01c0fc7bd5b0397670eb
https://doi.org/10.1371/journal.pone.0253852
https://doi.org/10.1371/journal.pone.0253852
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 46(11)
We investigated whether pheophorbide A (PhA) could serve as a selective breast cancer resistance protein (BCRP) substrate (victim) to screen in vivo using fluorescent live animal imaging for transporter-mediated interactions with orally administered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603818993aeb7c60e9adcb43c5dda624
https://pubmed.ncbi.nlm.nih.gov/30111622
https://pubmed.ncbi.nlm.nih.gov/30111622
Autor:
Ajay K. Israni, Amutha Muthusamy, William S. Oetting, Erin G. Schuetz, Branden S. Moriarity, James Fisher, Rory P. Remmel, Kazuto Yasuda, Casey R. Dorr, Pamala A. Jacobson, Baolin Wu, Weihua Guan
Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 engineering of the CYP3A5 *3 locus (rs776746) in human liver cell line HuH-7 (CYP3A5 *3/*3) has led to three CYP3A5 *1 cell lines by deletion of the exon 3B splice junction or po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5846d8f5fb576dd849a6aceae984f49
https://europepmc.org/articles/PMC5518718/
https://europepmc.org/articles/PMC5518718/
Autor:
Erin G. Schuetz, Yiping Fan, Ranjit K. Thirumaran, Xia Yang, Kazuto Yasuda, Stephen C. Strom, Amarjit S. Chaudhry
Publikováno v:
Drug Metabolism and Disposition. 41:1538-1547
Human liver gene regulatory (Bayesian) network analysis was previously used to identify a cytochrome P450 (P450) gene subnetwork with Aldo-keto reductase 1D1 (AKR1D1) as a key regulatory driver of this subnetwork. This study assessed the biologic imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a9db68cdb3d36c5d352af5645440c7
https://doi.org/10.1124/dmd.113.051672
https://doi.org/10.1124/dmd.113.051672
Autor:
Ko Fujimori, Soghra Fatima, Ranjit K. Thirumaran, Cynthia Cline, Brian P. Sorrentino, Kazuto Yasuda, Mihaela Onciu, Peter Vogel, Erin G. Schuetz, Sean Ekins, Yoshihiro Urade
Publikováno v:
Drug Metabolism and Disposition. 41:923-931
The subarachnoid space, where cerebrospinal fluid (CSF) flows over the brain and spinal cord, is lined on one side by arachnoid barrier (AB) cells that form part of the blood-CSF barrier. However, despite the fact that drugs are administered into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3846bfde623f6828c07379adff0314
https://doi.org/10.1124/dmd.112.050344
https://doi.org/10.1124/dmd.112.050344
Autor:
Sridhar Mani, William D. Figg, Susan E. Bates, Nicola F. Smith, Alex Sparreboom, Kazuto Yasuda, Erin G. Schuetz, Tristan M. Sissung
Publikováno v:
Annals of Pharmacotherapy. 44:1709-1717
Background: Several microtubule targeting agents are capable of inducing CYP3A4 via activation of the pregnane X receptor (PXR; NR1I2). Objective: To evaluate the CYP3A4 induction potential of vinblastine both clinically and in vitro and determine th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b99dcc4aea1a4c1205141d931e87988
https://doi.org/10.1345/aph.1p354
https://doi.org/10.1345/aph.1p354