Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kazutaka Sekiguchi"'
Autor:
Peter Bloomingdale, Tatiana Karelina, Vidya Ramakrishnan, Suruchi Bakshi, Florence Véronneau‐Veilleux, Matthew Moye, Kazutaka Sekiguchi, Guy Meno‐Tetang, Aparna Mohan, R. Maithreye, Veena A. Thomas, Frank Gibbons, Antonio Cabal, Jean‐Marie Bouteiller, Hugo Geerts
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 11, Pp 1399-1429 (2022)
Abstract Age‐related central neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, are a rising public health concern and have been plagued by repeated drug development failures. The complex nature and poor mechanistic understand
Externí odkaz:
https://doaj.org/article/d627f76b245a4babb9f9c159235ee333
Autor:
Medlock, Laura, Kazutaka Sekiguchi, Sungho Hong, Dura-Bernal, Salvador, Lytton, William W., Prescott, Steven A.
Publikováno v:
Journal of Neuroscience; 4/13/2022, Vol. 42 Issue 15, p3133-3149, 17p
Publikováno v:
Xenobiotica. 46:495-502
1. It was previously demonstrated that 10% of S-777469, a cannabinoid receptor 2 selective agonist, is metabolized to its carboxylic acid metabolite (S-777469 5-carboxylic acid, 5-CA) in humans in vivo, while the formation of 5-CA is extremely low in
Autor:
Aiko Nagano, Hiroshi Hasegawa, Shuichi Ohnishi, Ryosuke Watari, Kazutaka Sekiguchi, Akihiro Matsuda
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S61-S62
Autor:
Kazuo Hida, Kazutaka Sekiguchi
Ground-state and finite-temperature properties of $S=1/2$ Heisenberg ladders with a ferromagnetic leg, an antiferromagnetic leg, and antiferromagnetic rungs are studied. It is shown that a partial ferrimagnetic phase extends over a wide parameter ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97ce0191f240c28fe0942fd1576c197
http://arxiv.org/abs/1705.04836
http://arxiv.org/abs/1705.04836
Publikováno v:
Xenobiotica. 45:150-157
1. The metabolism and pharmacokinetics of S-777469 were investigated after a single oral administration of [14C]-S-777469 to healthy human subjects. 2. Total radioactivity was rapidly and well absorbed in humans, with Cmax of 11,308 ng eq. of S-77746
Publikováno v:
Xenobiotica. 44:48-58
1. The drug metabolism and pharmacokinetics of S-777469 were investigated in in vitro (rat, dog and human) and in in vivo (rats and dogs). 2. S-777469 was rapidly and well absorbed, with bioavailability values ranging from 50 to 70% in rats and dogs,
Autor:
Kazutaka Sekiguchi, Norihito Sato, Kana Watanabe, Takayuki Okuno, Hideki Tanioka, Yukari Tanaka, Naoki Omori, Hideo Yukioka, Yasunori Yokota, Hirohide Nambu, Akira Yukimasa, Naoki Kouyama
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(5)
We report a hit to lead study on a novel benzoxazole NPY Y5 antagonist. Starting from HTS hit 1, structure–activity relationships were developed. Compound 12 showed reduction of food intake and a tendency to suppress body weight gain over the 21-da