Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Kazutaka, Murayama"'
Autor:
Kazushige Hirata, Aoi Takahara, Satoshi Suzuki, Shumei Murakami, Kumi Kawaji, Akie Nishiyama, Mina Sasano, Mariko Shoji-Ueno, Emiko Usui, Kazutaka Murayama, Hironori Hayashi, Shinya Oishi, Eiichi N. Kodama
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108961- (2024)
Summary: Despite effective vaccines, measles virus (MeV) outbreaks occur sporadically. Therefore, developing anti-MeV agents remains important for suppressing MeV infections. We previously designed peptide-based MeV fusion inhibitors, M1 and M2, that
Externí odkaz:
https://doaj.org/article/4b8ecf24de4c4d94bb5037e933b019ed
Autor:
Yuko Makino, Chihiro Oe, Kazuya Iwama, Satoshi Suzuki, Akie Nishiyama, Kazuya Hasegawa, Haruka Okuda, Kazushige Hirata, Mariko Ueno, Kumi Kawaji, Mina Sasano, Emiko Usui, Toshiaki Hosaka, Yukako Yabuki, Mikako Shirouzu, Makoto Katsumi, Kazutaka Murayama, Hironori Hayashi, Eiichi N. Kodama
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Structural and biophysical studies of the inhibition of bacterial serine hydroxymethyltransferase (SHMT) by a human SHMT inhibitor used for cancer therapy, (+)-SHIN-1, identify SHMT as a potent antibacterial target.
Externí odkaz:
https://doaj.org/article/efb597c97e904da9b72ba16baed8e329
Autor:
Tomomi Kimura‐Someya, Miyuki Kato‐Murayama, Kazushige Katsura, Naoki Sakai, Kazutaka Murayama, Kazuharu Hanada, Mikako Shirouzu, Yuichi Someya
Publikováno v:
FEBS Open Bio, Vol 12, Iss 3, Pp 560-570 (2022)
Noroviruses have been identified as major causative agents of acute nonbacterial gastroenteritis in humans. Histo‐blood group antigens (HBGAs) are thought to play a major role among the host cellular factors influencing norovirus infection. Genogro
Externí odkaz:
https://doaj.org/article/334a8259cabc477988a84d5eff4e10d4
Autor:
Shin-ichiro Hattori, Bulut, Haydar, Hironori Hayashi, Naoki Kishimoto, Nobutoki Takamune, Kazuya Hasegawa, Yuri Furusawa, Seiya Yamayoshi, Kazutaka Murayama, Hirokazu Tamamura, Mi Li, Wlodawer, Alexander, Yoshihiro Kawaoka, Shogo Misumi, Hiroaki Mitsuya
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 9/10/2024, Vol. 121 Issue 37, p1-10, 22p
Autor:
Kanako Shimizu, Tomonori Iyoda, An Sanpei, Hiroshi Nakazato, Masahiro Okada, Shogo Ueda, Miyuki Kato-Murayama, Kazutaka Murayama, Mikako Shirouzu, Naoko Harada, Michihiro Hidaka, Shin-ichiro Fujii
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Kanako Shimizu et al. identify HLA-A24 high-binding epitopes in the SARS-CoV-2 spike region and investigate their cross-reactivity with CD8+ T cell receptors. These results provide further insight into CD8+ T cell cross-reactivity toward SARS-CoV-2 a
Externí odkaz:
https://doaj.org/article/b7cfecf00c01417f9f7847303e27b7d3
Publikováno v:
FEBS Open Bio, Vol 11, Iss 4, Pp 1132-1143 (2021)
Lysoplasmalogen‐specific phospholipase D (LyPls‐PLD) catalyzes reactions in a manner similar to those catalyzed by glycerophosphodiester phosphodiesterase (GDPD) and other well‐known PLDs. Although these enzymes hydrolyze the glycerophosphodies
Externí odkaz:
https://doaj.org/article/bbf2f88b14aa41a79b925e6cd21f2b5d
Autor:
Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when co
Externí odkaz:
https://doaj.org/article/86d3e81f7e794c15baedd9ad9a968412
Little involvement of recycled-amino acids from proteasomal proteolysis in de novo protein synthesis
Autor:
Shion Osana, Yasuo Kitajima, Suzuki Naoki, Hiroaki Takada, Kazutaka Murayama, Yutaka Kano, Ryoichi Nagatomi
Publikováno v:
Biochemical and Biophysical Research Communications. 634:40-47
Myoblast integrity is essential for skeletal muscle regeneration. Many intracellular proteins are degraded by the proteasome and converted to amino acids by aminopeptidases through the protein degradation pathway. Although we previously reported its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6cc8103f0902aa239d64304b5702da
https://doi.org/10.1016/j.bbrc.2022.09.113
https://doi.org/10.1016/j.bbrc.2022.09.113
Autor:
Dr. Naomi Ohbayashi, Dr. Kazutaka Murayama, Miyuki Kato‐Murayama, Dr. Mutsuko Kukimoto‐Niino, Dr. Tamami Uejima, Dr. Takayoshi Matsuda, Dr. Noboru Ohsawa, Prof. Shigeyuki Yokoyama, Prof. Hiroshi Nojima, Dr. Mikako Shirouzu
Publikováno v:
ChemistryOpen, Vol 7, Iss 9, Pp 713-719 (2018)
Abstract Gefitinib is the molecular target drug for advanced non‐small‐cell lung cancer. The primary target of gefitinib is the positive mutation of epidermal growth factor receptor, but it also inhibits cyclin G‐associated kinase (GAK). To rev
Externí odkaz:
https://doaj.org/article/1792a4ab9ff142d693f1b4b82f51f702
Autor:
Hiroaki Hamana, Yoshiaki Yasutake, Miyuki Kato-Murayama, Toshiaki Hosaka, Mikako Shirouzu, Shin-ichi Sakasegawa, Daisuke Sugimori, Kazutaka Murayama
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 87:74-81
Lysoplasmalogen-specific phospholipase D (LyPls-PLD) hydrolyzes choline lysoplasmalogen to choline and 1-(1-alkenyl)-sn-glycero-3-phosphate. Mutation of F211 to leucine altered its substrate specificity from lysoplasmalogen to 1-O-hexadecyl-2-hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347dcc6be424bba294a018b0ae49b86d
https://doi.org/10.1093/bbb/zbac169
https://doi.org/10.1093/bbb/zbac169