Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kazusane Takeuchi"'
Publikováno v:
Heliyon, Vol 6, Iss 3, Pp e03598- (2020)
The pathophysiology of type 2 diabetes mellitus (T2DM) is characterized by not only insulin resistance, but also the abnormal regulation of glucagon secretion, suggesting that antagonizing the glucagon-induced signaling pathway has therapeutic potent
Externí odkaz:
https://doaj.org/article/2782c2d46c6843e7b2cacfaf20320f2b
Publikováno v:
Heliyon, Vol 6, Iss 3, Pp e03598-(2020)
Heliyon
Heliyon
The pathophysiology of type 2 diabetes mellitus (T2DM) is characterized by not only insulin resistance, but also the abnormal regulation of glucagon secretion, suggesting that antagonizing the glucagon-induced signaling pathway has therapeutic potent
Autor:
Eri Wada, Tadahiro Kitamura, Daisuke Kohno, Satoru Kakizaki, Hiromi Yokota-Hashimoto, Kazusane Takeuchi, Osamu Kikuchi, Takayoshi Suga, Sho Matsui, Masaki Kobayashi, Masanobu Yamada, Tsutomu Sasaki
Publikováno v:
Molecular metabolism. 19
Objectives It is controversial whether sodium glucose transporter (SGLT) 2 inhibitors increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role of SGLT1 in α cells is also unclear. We aimed to elucidate these points
Autor:
Yoshifumi Harada, Jun Kanno, Yuuki Imai, Katsuhide Igarashi, Shu Takeda, Takahiro Matsumoto, Yoko Yamamoto, Daniel Metzger, Pierre Chambon, Andrée Krust, Shingo Sato, Kunio Takaoka, T. John Martin, Hiroshi Takayanagi, Kazusane Takeuchi, Takashi Nakamura, Shigeaki Kato, Hiroshi Nishina, Yoshiaki Azuma
Publikováno v:
Cell
Cell, Elsevier, 2007, 130 (5), pp.811-23. ⟨10.1016/j.cell.2007.07.025⟩
Cell, Elsevier, 2007, 130 (5), pp.811-23. ⟨10.1016/j.cell.2007.07.025⟩
Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the molecular basis for this is unknown. Here, we report a critical role for the osteoclastic estrogen receptor alpha (ERalpha) in mediating estrogen-dependent bone mai