Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kazuo Yagui"'
Autor:
Yasushi Saito, Ko Ishikawa, Kenichi Sakurai, Asami Tanaka, Takayuki Ishibashi, Kentaro Kaneko, Jun Ogino, Tsuyoshi Matsumoto, Koutaro Yokote, Kazuo Yagui
Publikováno v:
DNA and Cell Biology. 30:539-544
Aquaporin-1 (AQP1), a water channel protein, has been shown to play an important role in tumor growth and angiogenesis in mouse endothelial cells. We recently reported that the expression of AQP1 mRNA was induced in cultured human retinal vascular en
Autor:
Y. Suzuki, Naotake Hashimoto, Masato Taira, Naoto Seki, Fumio Shimada, Hideichi Makino, S. Yagi, Yasushi Saito, Kazuo Yagui, K. Amano
Publikováno v:
Hormone and Metabolic Research. 40:833-837
Tyrosine phosphorylation of the insulin receptor is the initial event following receptor binding to insulin, and it induces further tyrosine phosphorylation of various intracellular molecules. This signaling is countered by protein tyrosine phosphata
Autor:
S. Yoshida, Kenichi Sakurai, Kou Ishikawa, Masato Taira, Hiroyuki Sano, Hideichi Makino, Naoto Seki, Kazuo Yagui, Yoshifumi Suzuki, Yuriko Yoshida, Seikou Horiuchi, Yasushi Saito, Naotake Hashimoto, Sayaka Yagi
Publikováno v:
Metabolism. 56:1591-1598
Advanced glycation end products (AGEs), among the most important causes of atherosclerosis in diabetes mellitus, stimulate the proliferation of smooth muscle cells (SMCs). Smooth muscle cells are central in the formation of atherosclerotic lesions, w
Autor:
Kazuaki Kanai, Miho Nakata, Sonoko Misawa, Setsu Sawai, Taku Hattori, Noriko Tamura, Kazuo Yagui, Satoshi Kuwabara
Publikováno v:
Neurology. 66:1545-1549
Background: In diabetic nerves, activation of the polyol pathway via an aldose reductase and the resulting impairment of the Na + –K + pump would lead to a decreased transaxonal Na + gradient and thereby reduced nodal Na + currents. Objective: To i
Autor:
Sonoko Misawa, Satoshi Kuwabara, Yukiko Kitano, Kazue Ogawara, Kazuo Yagui, Takamichi Hattori
Publikováno v:
Clinical Neurophysiology. 115:2525-2529
Objective : To investigate the effects of hyperglycemia on axonal excitability in human diabetics. Diabetic nerve dysfunction is partly associated with the altered polyol pathway and Na + –K + ATPase activity, probably resulting in a decrease in th
Autor:
Yoshiharu Tokuyama, Kenichi Sakurai, Azuma Kanatsuka, Naotake Hashimoto, Yasushi Saito, Kazuo Yagui
Publikováno v:
Metabolism. 50:812-818
We tried to characterize the clinical features associated with glucose metabolism in the development of diabetes. Study subjects were glucose-tolerant subjects without a family history of diabetes (normal glucose tolerance [NGT]1 group, n = 15) and w
Autor:
Fumio Shimada, T. Egashira, K. Matsui, Azuma Kanatsuka, Y. Suzuki, Kenichi Sakurai, Naotake Hashimoto, Hideichi Makino, Naoto Seki, Yoshiharu Tokuyama, Yasushi Saito, Kazuo Yagui, R. Fujii
Publikováno v:
Hormone and Metabolic Research. 32:316-320
Mutations of the hepatocyte nuclear factor 4 alpha (HNF-4alpha) gene have been demonstrated in maturity-onset diabetes of the young (MODY) 1 families. To investigate the possibility that the HNF-4alpha gene contributes to the onset of non-insulin-dep
Autor:
Yoshiharu Tokuyama, Yasushi Saito, Jun-ichi Miyazaki, Katsumi Yamada, Hideichi Makino, Azuma Kanatsuka, Naotake Hashimoto, Yoshifumi Suzuki, Nobuko Ishizuka, Kazuo Yagui
Publikováno v:
Metabolism. 48:1485-1492
Cytokines induce apoptosis in pancreatic beta cells, but the exact mechanisms and sequence of events are not clear. Here, we investigate a role for tumor necrosis factor alpha (TNF-alpha) in the apoptosis of beta cells. Using the ribonuclease (RNase)
Autor:
Kazuo Yagui, Osamu Nozaki, Takashi Iizuka, Tetsuo Nishikawa, Hiroki Tsuchida, Nobuhiko Kuramoto, Masao Omura, Yasushi Saito, Azuma Kanatsuka, Hideichi Makino, Hiroko Ito
Publikováno v:
American Journal of Kidney Diseases. 33:276-281
We investigated the influence of the angiotensin-converting enzyme (ACE) gene on the onset and/or progression of diabetic nephropathy in 62 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM; type II diabetes). Because a number of
Autor:
Hidenori Takahashi, Rie Iwai, Tomohiko Yoshida, Koutaro Yokote, Katsuya Yoshida, Kenichi Sakurai, Naotake Hashimoto, Kazuo Yagui, Atsuya Horie, Yasushi Saito, Shouji Yoshida, Sachiko Hatanaka, Hiroko Kurosawa
Publikováno v:
Diabetes Research and Clinical Practice. 75:27-29
Werner syndrome is a premature aging disease characterized by genomic instability and increased cancer risk. Here, we report a 45-year-old diabetic man as the first Werner syndrome patient found to have an adiponectin gene mutation. Showing graying a