Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kazuo Tsukidate"'
Autor:
Jiro Sonoda, Yoshikazu Taketa, Aya Goto, Etsuko Ohta, Yuki Seki, Kazuo Tsukidate, Kyoko Nakano, Toyohiko Aoki, Satoru Hosokawa, Kazuhiro Hayakawa, Akira Inomata
Publikováno v:
Journal of Toxicologic Pathology
Maxillary gingivae from male and female Crl:CD(SD) rats at 12, 16, 21, and 34 weeks of age were examined histologically. The incidence of gingivitis was approximately 40%, with no age or sex predilection, and was most frequent between the first and s
Autor:
Yuki Momozawa, Jyoji Yamate, Akira Inomata, Kazuo Tsukidate, Yoshikazu Taketa, Midori Yoshida, Toyohiko Aoki, Satoru Hosokawa, Kazuhiro Hayakawa, Kyoko Nakano, Jiro Sonoda
Publikováno v:
Toxicologic Pathology. 39:372-380
Ethylene glycol monomethyl ether (EGME) is a known reproductive toxicant that induces luteal hypertrophy in rat ovaries. In this study, we characterized the histopathological features of corpora lutea (CL) from EGME–treated rats and compared them w
Autor:
Shigeki Sawada, Toyohiko Aoki, Kanako Uchida, Atsushi Hakura, Yuji Hori, Akiyoshi Suganuma, Kazuo Tsukidate, Tadakazu Sugihara
Publikováno v:
Genes and Environment. 32:1-6
Dimethyl sulfoxide (DMSO) is generally believed to be non-cytotoxic at the concentrations used in the routine Ames test. In the present study, we found that DMSO reduced the number of bacterial survivors at a concentration of 14% in the treatment mix
Autor:
Shigeki Sawada, Yuji Hori, Akiyoshi Suganuma, Kazuo Tsukidate, Kanako Uchida, Toyohiko Aoki, Atsushi Hakura
Publikováno v:
Genes and Environment. 32:53-60
The effect of dimethyl sulfoxide (DMSO) on the mutagenicity of 14 promutagens belonging to several chemical classes and one direct mutagen as a reference compound was examined in the Ames preincubation test, to clarify how much the test results were
Autor:
Tetsushi Dodo, Toshio Imai, Tomomi Ando, Kerns William D, Toyohiko Aoki, Kazuo Tsukidate, Satoru Motooka
Publikováno v:
Journal of Toxicologic Pathology. 15:111-118
The tumorigenic potential of clofibrate, a peroxisome proliferator, was evaluated in a 26-week bioassay using CB6F1-TgHras2 (rasH2) mice carrying a human prototype c-Ha-ras gene. Clofibrate was administered to rasH2 mice orally by gavage at doses of
Autor:
Yoshikazu Taketa, Sandeep Akare, Jiro Sonoda, Kazuhiro Hayakawa, Kyoko Nakano-Ito, David Hutto, Kazuo Tsukidate, Yasuhiro Fujikawa, Satoru Hosokawa, Akira Inomata, Yvonne Van Gessel, Etsuko Ohta
Publikováno v:
Toxicologic pathology. 42(8)
Vascular endothelial growth factor (VEGF) receptor tyrosine kinase (RTK) inhibitors are reported to cause reversible mucosal hyperplasia (adenosis) in the duodenum of rats; however, the pathogenesis is not fully elucidated. Using lenvatinib, a VEGF R
Publikováno v:
Life Sciences. 68:2665-2673
The present paper describes the role of conjugating enzymes in the development of hepatotoxicity after administration of repeated doses of a novel monoamine oxidase type-A (MAO-A) inhibitor, (5 R )-3-[2-((1 S )-3-cyano-1-hydroxypropyl)benzothiazol-6-
Autor:
Kohei Sawada, Taisuke Uehara, Toyohiko Aoki, Akiyoshi Suganuma, Kazuo Tsukidate, Motohiro Shiotani, Dai Kakiuchi, Kyoko Nakano-Ito
Publikováno v:
Molecular medicine reports. 11(2)
Vitamin A deficiency (VAD) caused by malnutrition and certain intestinal diseases induces visual impairments, including night blindness and photoreceptor cell dysfunction as indicated by reduced a‑ and b‑waves in an electroretinogram (ERG). The e
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 447:239-247
We recently demonstrated that not all organs with a high rate of induction of mutation in the lacZ transgene develop tumors in the λ lacZ transgenic mice (Muta™Mouse) used for a long-term carcinogenicity study with benzo[ a ]pyrene (BP). To better
Publikováno v:
Medical Electron Microscopy. 32:62-65
A new method for preparing electron microscopic specimens of Helicobacter pylori was developed and used to examine the ultrastructure of this bacterium. We have also investigated the morphological changes in the bacterium when exposed to amoxicillin