Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Kazuo Takahama"'
Publikováno v:
Indian Journal of Physiology and Pharmacology. 67:57-63
Objectives: Centrally-acting antitussives with inhibitory effects on G protein-coupled inwardly rectifying potassium (GIRK) channels have been shown to also inhibit methamphetamine-induced hyperactivity in mice. In this study, we examined if cloperas
Publikováno v:
Journal of Neurophysiology; Jul2023, Vol. 130 Issue 1, p56-60, 5p
Autor:
Fumio Soeda, Kazuya Masuzaki, Yukiko Fujii, Risa Miki, Takayuki Koga, Akihisa Toda, Kazuo Takahama
Publikováno v:
LUTS: Lower Urinary Tract Symptoms. 13:400-409
Objectives An enriched environment (EE) has been known to promote structural changes in the brain and enhance learning and emotional performance. However, little is known about the effect of an EE on brain stem functions, such as the micturition func
Autor:
Kazuo Takahama
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 3, Pp 146-151 (2012)
Antitussive drugs have been used for decades and their modes of action are well elucidated. However, recent studies on the mechanism of their antitussive action seem to be opening a new way for discovery or development of novel drugs for intractable
Externí odkaz:
https://doaj.org/article/5e2fb14c786e41698a49a7721e8846e0
Autor:
Kimi Araki, Min Chul Shin, Shogo Misumi, Fumio Soeda, Ken Ichi Yamamura, Ikutaro Honda, Sokichi Honda, Kazuo Takahama
Publikováno v:
Neuroscience Letters. 665:140-146
We previously reported that non-narcotic antitussives possessing inhibitory actions on G protein-coupled inwardly rectifying potassium (GIRK) channels have antidepressant-like effects in the forced swimming test in normal and adrenocoticotropic hormo
Publikováno v:
Pharmacology. 102:37-41
In this study, we investigated the effect of histamine on capsaicin-induced current and its influence by suplatast in rat trigeminal ganglia neurons using a patch-clamp technique. We found that histamine directly potentiated capsaicin-induced current
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 311:L770-L778
In this study, we investigated the effects of suplatast on acutely dissociated single neurons of sensory and paratracheal ganglia using a patch-clamp technique. Suplatast had little effect on various responses caused by capsaicin, acid, bradykinin, s
Publikováno v:
Behavioural Brain Research. 302:269-278
We investigated whether tipepidine exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone (ACTH)-treated rats, which is known as a treatment-resistant depression model, and we studied the pharmacological mecha
Autor:
Ryo Kawahara, Shogo Misumi, Risa Miki, Ikutaro Honda, Ryota Hamasaki, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Publikováno v:
Brain research. 1710
We previously reported that centrally acting non-narcotic antitussives, including tipepidine, inhibit G-protein-coupled inwardly rectifying potassium (GIRK) channel-activated currents of neurons. In addition, when administered at a cough suppressant