Th17 (PP-014)

Autor: A. E. Hauser, H. Wu, E. Esplugues, M. Tsuruoka, W. Niedbala, J. Elia, S. Tsuyoshi, B. Cai, V. Flamand, S. Iwamoto, M. Hirashima, S. Tanaka, H. L. Qian, H. Kai, C. Yu, A. Yoshimura, A. Yamauchi, J. Masuyama, Y. Kang, J. M. Wilson, J. Rohrer, T. Tanaka, M. Weinstein, F. Tsuji, D. Chuang, Y. Xiao, S. Yamada, E. A. M. Veraar, S. Wu, Yoh-ichi Tagawa, T. Kamiyama, S. M. Vieira, M. Tajima, S. Huber, J. C. Alves-Filho, F. Suzuki, J. Rabenstein, M. Kadowaki, K. Masuko, C. Liu, I. Debock, S. Oomizu, A. Chu, H. Aono, J. Kang, J. Lastovicka, K. Ishihara, A. Sediva, T. Arikawa, N. Malhotra, S. Miuznoe, B. Oh, X. Wang, F. Zhu, H. Yasuhara, J. M. Coquet, S. Lee, I. Matumoto, D. Wakita, T. Koga, Katsuko Sudo, K. Matsushima, S. Saijo, F. Q. Cunha, U. A. K. Betz, A. Ikejiri, H. Park, S. Y. Fukada, J. Yoon, H. Uga, O. Beretta, D. Noguchi, C. Chu, M. Roecken, H. Sepulveda, B. A. Wu-Hsieh, T. Matsuda, T. Okazawa, S. Kim, H. Hirota, H. Kitamura, Y. Liu, D. N. Herndon, T. Town, F. Liu, A. Yazdi, T. Niki, H. Lee, C. Deng, M. Kono, S. Feske, N. Ueda, R. Horvath, T. Sumida, G. Licandro, T. Nishimura, M. Harada, S. Koyasu, P. B. Ernst, M. Murakami, T. Sato, M. Suico, S. Black, M. Kanayama, Kazuo Sugane, C. Kitabayashi, K. Ghoreschi, C. Matsumoto, R. A. Flavell, T. Atsumi, M. G. Jeschke, E. A. O'Donnell, M. Nishihara, J. Borst, M. Kobayashi, Z. Lining, R. Spreafico, J. Morimoto, H. Ogura, A. Haberman, T. Kaisho, M. Pétein, N. Gagliani, T. Fukada, A. Miyazaki, J. Tschopp, G. van der Horst, J. Soh, S. Park, Yoichiroh Iwakura, T. Hu, S. Delbauve, Q. Wang, J. Ma, D. C. Gruenert, A. Mitani, Y. Miyamoto, S. Ikeda, P. Ricciardi-Castagnoli, S. Iwai, H. Watanabe, E. Huseby, T. Uede, S. Suzuki, C. McCarl, S. Hida, K. Ichiyama, I. Glocova, I. Azuma, S. Hojyo, K. Oguchi, F. Y. Liew, A. Mortellaro, J. Yu, M. Goldman, S. Nakae, A. Polouckova, J. Brueck, W. Ohashi, R. Spisek, M. Ikeda, T. Hirano, A. Inatsu, O. Kim, C. Conforti-Andreoni, M. Yanagida, S. Khalil, Masaya Takamoto, M. Festing, M. Mamura, S. Miaw, H. Kurata, M. Kanamoto, S. Nagai, U. Ikeda

Publikováno v: International Immunology. 22:i96-i101

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88215d3af015208cab10445f1625ca06
https://doi.org/10.1093/intimm/dxq101

Interleukin-21 stimulates B-cell immunoglobulin E synthesis in human beings concomitantly with activation-induced cytidine deaminase expression and differentiation into plasma cells

Autor: Kazunaga Agematsu, Hans D. Ochs, Shinji Kobayashi, Nagumo Haruo, Kazuo Sugane

Publikováno v: Human Immunology. 70:35-40

Interleukin (IL)-21 downregulates immunoglobulin E (IgE) production in murine systems by inhibiting germline epsilon transcription in IL-4-stimulated B cells. We here sought to clarify the function of IL-21 in human B-cell IgE synthesis. IL-21 dramat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93b23cfff83f81fa78f10d44f68997d
https://doi.org/10.1016/j.humimm.2008.10.021

The ICOS-ligand B7-H2, expressed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system

Autor: Xuesong Qian, Takuma Hayashi, Yoh-ichi Tagawa, Kazunaga Agematsu, Gordon J. Freeman, Kazuo Sugane

Publikováno v: European Journal of Immunology. 36:906-918

The mechanism of immune defense against pathogens in the lung, has so far been poorly understood. Here, we show that human type II alveolar epithelial cells play a key role in defense via interactions between B7 homolog (B7h), also known as ICOS liga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542eff2db7826e8b8cecb1a064969c31
https://doi.org/10.1002/eji.200535253

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA–induced IL-12 production and Th cell differentiation

Autor: Hiroyoshi Ishizaki, Seiichi Matsuo, Jun Miyoshi, Kazuo Sugane, Tetsuya Matsuguchi, Naotake Tsuboi, Masaya Takamoto, Yasunobu Yoshikai, Yasuhiro Shimada, Akio Masuda, Mutsuhiro Ohata, Kenji Sugimoto

Publikováno v: Journal of Clinical Investigation. 114:857-866

A serine/threonine protein kinase, Cot/Tpl2, is indispensable for extracellular signal-regulated kinase (ERK) activation and production of TNF-alpha and PGE2 in LPS-stimulated macrophages. We show here that Cot/Tpl2 is also activated by other Toll-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295976e9a999b29fb48e0a7fbbb698b5
https://doi.org/10.1172/jci20014

Absence of Memory B Cells in Patients with Common Variable Immunodeficiency

Autor: Atsushi Komiyama, Takeshi Futatani, Shigeo Koyasu, Hans D. Ochs, Sho Hokibara, Harumi Suzuki, Satoshi Tsukada, Norimoto Kobayashi, Kazuo Sugane, Masaya Takamoto, Toshio Miyawaki, Kazunaga Agematsu

Publikováno v: Clinical Immunology. 103:34-42

The molecular basis of common variable immunodeficiency (CVID) is unknown. To assess humoral immunity in CVID, we selected 24 patients with early or late onset of disease. X-linked agammaglobulinemia (XLA), X-linked hyper-IgM syndrome (XHIM), and non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bcbb17ea08d2e7b61ded9d845da69d
https://doi.org/10.1006/clim.2001.5197