Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Kazuo Ohashi"'
Autor:
Hiroyasu Nishimaki, Yoshikatsu Saitoh, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Ibrahim Fathi, Hiroki Yamana, Kazuo Ohashi, Shigehito Miyagi, Takashi Kamei, Michiaki Unno, Masafumi Goto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Clinical hepatocyte transplantation (HTx) is only performed without general anesthesia, while inhalation anesthetics are usually used in animal experiments. We hypothesized that isoflurane may be a possible reason for the discrepancy between
Externí odkaz:
https://doaj.org/article/7926e2eaf84447a69e4611e0ec36fbd0
Publikováno v:
Renal Replacement Therapy, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Background To manage the anemic status in hemodialysis (HD) patients, a well-balanced combination therapy based on the use of erythropoiesis-stimulating agents (ESAs) and iron supplementation is essential. Serum ferritin level and transferri
Externí odkaz:
https://doaj.org/article/27f192e4982b4a5d9ee1b70c2f9fced5
Autor:
Hiroyuki Ogasawara MD, PhD, Akiko Inagaki PhD, Ibrahim Fathi MD, PhD, Takehiro Imura, Hiroki Yamana MD, Yoshikatsu Saitoh MD, PhD, Muneyuki Matsumura MD, PhD, Kengo Fukuoka MD, PhD, Shigehito Miyagi MD, PhD, Yasuhiro Nakamura MD, PhD, Kazuo Ohashi MD, PhD, Michiaki Unno MD, PhD, Takashi Kamei MD, PhD, Masafumi Goto MD, PhD
Publikováno v:
Cell Transplantation, Vol 30 (2021)
Intraportal injection is regarded as the current standard procedure of hepatocyte transplantation (HTx). In islet transplantation, which shares many aspects with HTx, recent studies have clarified that instant blood-mediated inflammatory reaction (IB
Externí odkaz:
https://doaj.org/article/d03b7c9b8fc2490381bd146ed932a419
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 183-193 (2017)
Gene therapy during neonatal and infant stages is a promising approach for hemophilia B, a congenital disorder caused by deficiency of blood coagulation factor IX (FIX). An adenovirus (Ad) vector has high potential for use in neonatal or infant gene
Externí odkaz:
https://doaj.org/article/4840dbd55f114bdca96328cb69a54421
Autor:
Toshio Miki, Ludivina Vazquez, Lisa Yanuaria, Omar Lopez, Irving M. Garcia, Kazuo Ohashi, Natalie S. Rodriguez
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Mucopolysaccharidosis type 1 (MPS-1), also known as Hurler’s disease, is a congenital metabolic disorder caused by a mutation in the alpha-L-iduronidase (IDUA) gene, which results in the loss of lysosomal enzyme function for the degradation of glyc
Externí odkaz:
https://doaj.org/article/64afa4737b334b2da07ac998db71302a
Autor:
Yoshinori Arisaka, Jun Kobayashi, Kazuo Ohashi, Kohei Tatsumi, Kyungsook Kim, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
Publikováno v:
Regenerative Therapy, Vol 3, Iss C, Pp 97-106 (2016)
A heparin-modified thermoresponsive surface bound with heparin-binding epidermal growth factor-like growth factor (HB-EGF) was designed to allow creation of transferrable and functional hepatocyte sheets. A heparin-modified thermoresponsive surface w
Externí odkaz:
https://doaj.org/article/6b21b945e2d642e7815422dafe10d337
Autor:
Ryota Okamoto, Kazuo Takayama, Naoki Akita, Yasuhito Nagamoto, Daiki Hosokawa, Shunsuke Iizuka, Fuminori Sakurai, Hiroshi Suemizu, Kazuo Ohashi, Hiroyuki Mizuguchi
Publikováno v:
Cell Transplantation, Vol 27 (2018)
Instead of liver transplantation or liver-directed gene therapy, genetic liver diseases are expected to be treated effectively using liver tissue engineering technology. Hepatocyte-like cells (HLCs) generated from human-induced pluripotent stem (iPS)
Externí odkaz:
https://doaj.org/article/b3b5dab495eb42eea75731c6d7b616ea
Autor:
Kengo Fukuoka, MD, Akiko Inagaki, PhD, Yasuhiro Nakamura, MD, PhD, Muneyuki Matsumura, MD, Satoru Yoshida, MD, PhD, Takehiro Imura, Yasuhiro Igarashi, MD, PhD, Shigehito Miyagi, MD, PhD, Kazuo Ohashi, MD, PhD, Shin Enosawa, MD, PhD, Takashi Kamei, MD, PhD, Michiaki Unno, MD, PhD, Noriaki Ohuchi, MD, PhD, Susumu Satomi, MD, PhD, Masafumi Goto, MD, PhD
Publikováno v:
Transplantation Direct, Vol 3, Iss 7, p e176 (2017)
Background. No optimal methods for short-term hepatocyte preservation have been established. We have recently developed a prominent oxygen-permeable bag (Tohoku Device [TD]) for pancreatic islet culture and transplantation. In this study, we investig
Externí odkaz:
https://doaj.org/article/dd866af0c6a04eee8e960daef27ab9a9
Autor:
Yusuke Sakai, Makiko Koike, Hideko Hasegawa, Kosho Yamanouchi, Akihiko Soyama, Mitsuhisa Takatsuki, Tamotsu Kuroki, Kazuo Ohashi, Teruo Okano, Susumu Eguchi
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70970 (2013)
Cell sheet engineering is attracting attention from investigators in various fields, from basic research scientists to clinicians focused on regenerative medicine. However, hepatocytes have a limited proliferation potential in vitro, and it generally
Externí odkaz:
https://doaj.org/article/3bd66a6285b44476b99318a25242c886
Autor:
Kohei Tatsumi, Mitsuhiko Sugimoto, David Lillicrap, Midori Shima, Kazuo Ohashi, Teruo Okano, Hideto Matsui
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83280 (2013)
Gene- or cell-based therapies aimed at creating delivery systems for coagulation factor VIII (FVIII) protein have emerged as promising options for hemophilia A treatment. However, several issues remain to be addressed regarding the efficacies and adv
Externí odkaz:
https://doaj.org/article/6f4e401cb367400fae31629a25bc4a5a