Výsledky vyhledávání - "Kazuo Numata"

In vitro and in vivo Antibacterial Activity and Pharmacokinetics of SC-002 and Its Derivative, SC-004: New Oral Cephalosporins

Autor: M. Nozawa, Takatoshi Nagate, Kazuhiko Sugita, Tamejiro Hiyama, Rumi Yamamoto, Toshi Akashi, Akira Onodera, Mikako Fujita, Kiyosi Kondo, Kazunori Hanada, Kazuo Numata, M. Matsuyama, H. Saito, Takeo Kobori, Yoshie Kaneda

Publikováno v: Chemotherapy. 47:157-169

SC-002 is a novel oral cephalosporin possessing a unique thiadiazolylethenyl moiety at the 3 position. In the present study, it was the most active against gram-positive bacteria among oral cephalosporins such as cefdinir (CFDN), cefpodoxime, cefdito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925efba70976a6c1ce4e5947772f2adf
https://doi.org/10.1159/000063217

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Synthesis and biological properties of 3-[()-2-(1,2,3-Thiadiazolyl)ethenyl]-substituted cephalosporins and related compounds: new oral cephalosporins

Autor: Kazuo Numata, Mikako Fujita, Rumi Yamamoto, Kazunori Hanada, Toshi Akashi, Takeo Kobori, Takatoshi Nagate, Yoshie Kaneda, Tamejiro Hiyama, Kiyosi Konda, Kazuhiko Sugita

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:2225-2230

A series of cephalosporins possessing a [( Z -2-(1,2,3-thiadiazolyl)ethenl] moiety at C-3 were synthesized and their biological properties were examined. SC-002 (1a) exhibited excellent activity against both Gram-positive and Gram-negative bacteria.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a74b9a8d201bcab20b7c05b9a6cd9f0f
https://doi.org/10.1016/s0960-894x(01)80929-x

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In vitro and in vivo antibacterial activities of clarithromycin

Autor: Takatoshi Nagate, Takeo Ono, Matsuhisa Inoue, Kazuo Numata, Susumu Mitsuhashi

Publikováno v: Chemotherapy. 42(3)

The in vitro and in vivo antibacterial activities of clarithromycin (CAM), a new oral macrolide antibiotic, were compared with those of erythromycin (EM), josamycin (JM) and rokitamycin (RKM). The antibacterial spectrum and in vitro activities of CAM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992ea0b9b87b72516cfa9961ccebc252
https://pubmed.ncbi.nlm.nih.gov/8983882

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Studies on cephalosporin antibiotics. VI. Synthesis, antibacterial activity and oral efficacy in mice of new 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)-acetamido]-3- (substituted alkylthio)cephalosporins

Autor: Hiroshi Fukushima, Akira Onodera, Kazuo Numata, Takatoshi Nagate, Chihiro Yokoo

Publikováno v: The Journal of antibiotics. 45(9)

A series of new 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido] cephalosporins (1) having various substituted alkylthio groups at the C-3 position of the cephem nucleus were prepared and evaluated for antibacterial activity and oral ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7c63d629f0f9f6befdda92a996fddb
https://pubmed.ncbi.nlm.nih.gov/1429240

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Chemical modification of erythromycins. III. In vitro and in vivo antibacterial activities of new semisynthetic 6-O-methylerythromycins A, TE-031 (clarithromycin) and TE-032

Autor: Kazuo Numata, Yoko Misawa, Kazuhiko Sugita, Sadafumi Omura, Junko Miyachi, Kenji Yamada, Takeo Ono, Takatoshi Nagate, Shigeo Morimoto

Publikováno v: The Journal of antibiotics. 43(3)

The in vitro and in vivo antibacterial activities of 6-O-methylerythromycin A (TE-031, A-56268, or clarithromycin) and 6, 11-di-O-methylerythromycin A (TE-032) have been compared with those of erythromycin A (EM) and josamycin (JM). TE-031 and TE-032

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dae3b717c83ba00cb27ccd4c6130d53
https://pubmed.ncbi.nlm.nih.gov/2139023

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The susceptibility of Campylobacter pylori to antiulcer agents and antibiotics

Autor: Kazunori Hanada, Isamu Kondo, Kazuo Numata, Takatoshi Nagate

Publikováno v: Journal of clinical gastroenterology. 12

The antibacterial activities of antiulcer agents and antibiotics against Campylobacter pylori were studied. The MIC90 values of three kinds of antibiotics--macrolides, beta-lactams, and metronidazole--were 0.05-0.78, 0.39-1.56, and 12.5 micrograms/ml

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a1602e0ff3ae2693bc4fa036131dc3
https://pubmed.ncbi.nlm.nih.gov/2212539

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