Zobrazeno 1 - 10
of 415
pro vyhledávání: '"Kazuo Nakamoto"'
Autor:
Yildirim Ozdemir, Kazuo Nakamoto, Bruno Boivin, Daniel Bullock, Nick A. Andrews, Rafael González-Cano, Michael Costigan
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Chronic pain occurs at epidemic levels throughout the population. Hypersensitivity to touch, is a cardinal symptom of chronic pain. Despite dedicated research for over a century, quantifying this hypersensitivity has remained impossible at scale. To
Externí odkaz:
https://doaj.org/article/5d27109358424a11bbe65bcdcb955e54
Publikováno v:
Neuropsychopharmacology Reports, Vol 42, Iss 1, Pp 52-58 (2022)
Abstract Aims Fatty acid–binding protein (FABP) regulates polyunsaturated fatty acid (PUFA) intracellular trafficking and signal transduction. Our previous studies demonstrated that the alteration of PUFA in the hypothalamus is involved in pain pro
Externí odkaz:
https://doaj.org/article/6971315f2a5144cb968999ca82395c09
Autor:
Yuko Sadamura, Shanta Thapa, Ryota Mizunuma, Yuki Kambe, Akira Hirasawa, Kazuo Nakamoto, Shogo Tokuyama, Koji Yoshimoto, Kazunori Arita, Atsuro Miyata, Tatsuki Oyoshi, Takashi Kurihara
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The free fatty acid receptor 1 (FFAR1) is suggested to function as a G protein-coupled receptor (GPR40) for medium-to-long-chain free fatty acids. Previous studies on the expression of FFAR1 revealed that the nigrostriatal region is one of the areas
Externí odkaz:
https://doaj.org/article/9238288067b749e18effdf1e453f8e7a
Autor:
Fuka Aizawa, Takashi Nishinaka, Takuya Yamashita, Kazuo Nakamoto, Takashi Kurihara, Akira Hirasawa, Fumiyo Kasuya, Atsuro Miyata, Shogo Tokuyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 4, Pp 249-254 (2016)
The free fatty acid receptor 1 (GPR40/FFAR1) is a G protein-coupled receptor, which is activated by long chain fatty acids. We have previously demonstrated that activation of brain GPR40/FFAR1 exerts an antinociceptive effect that is mediated by the
Externí odkaz:
https://doaj.org/article/3aad26b6d1e04c5194e19fc15be5d834
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Our previous studies demonstrated that emotional dysfunction associated with early life stress exacerbated nerve injury-induced mechanical allodynia. Sex differences were observed in several anxiety tests, but not in mechanical allodynia. To elucidat
Externí odkaz:
https://doaj.org/article/84475fa67b7f4cfe9799101bb4112fc6
Autor:
Kazuo Nakamoto, Fuka Aizawa, Kei Miyagi, Takuya Yamashita, Mitsumasa Mankura, Yutaka Koyama, Fumiyo Kasuya, Akira Hirasawa, Takashi Kurihara, Atsuro Miyata, Shogo Tokuyama
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180610 (2017)
We previously showed that activation of G protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFAR1) signaling modulates descending inhibition of pain. In this study, we investigated the involvement of fatty acid-GPR40/FFAR1 signaling in th
Externí odkaz:
https://doaj.org/article/9744065312eb4d3bb8e4c30d79913407
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 1, Pp 112-115 (2014)
Abstract.: The functional role of brain G protein–coupled receptor 40 (GPR40) remains unclear. We investigated GPR40 signaling in depression-related behavior in mice via the forced swim test. A repeated but not a single intracerebroventricular admi
Externí odkaz:
https://doaj.org/article/14c69d740140410e8ebe789493563ece
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 3, Pp 242-254 (2014)
Abstract.: In clinical pharmacotherapy, therapeutic benefits and adverse effects of medicines differ substantially between individuals and are often determined by their blood levels. Critical regulators influencing the pharmacokinetics and pharmacody
Externí odkaz:
https://doaj.org/article/77e95b41629a4e1381926b94ad0b38cc
Autor:
Kazuo Nakamoto, Takashi Nishinaka, Naoya Sato, Mitsumasa Mankura, Yutaka Koyama, Fumiyo Kasuya, Shogo Tokuyama
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81563 (2013)
GPR40 has been reported to be activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). However, reports studying functional role of GPR40 in the brain are lacking. The present study focused on the relationship between pain regulation
Externí odkaz:
https://doaj.org/article/c7b84b5003f446ffb110bdf95fb9943c
Autor:
Ozdemir, Yildirim, Kazuo Nakamoto, Boivin, Bruno, Bullock, Daniel, Andrews, Nick A., González-Cano, Rafael, Costigan, Michael
Publikováno v:
Frontiers in Pharmacology; 2024, p1-12, 12p