Zobrazeno 1 - 10
of 622
pro vyhledávání: '"Kazuo Maruyama"'
Autor:
Fumiko Hagiwara, Daiki Omata, Lisa Munakata, Saori Kageyama, Kazuo Maruyama, Nobuki Kudo, Ryo Suzuki
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1599 (2023)
Glioblastoma is a highly invasive and fatal disease. Temozolomide, a blood–brain barrier (BBB)-penetrant therapeutic agent currently used for glioblastoma, does not exhibit sufficient therapeutic effect. Cisplatin (CDDP), a versatile anticancer dru
Externí odkaz:
https://doaj.org/article/c65ceb1e7dc246b4bbe5fb81aac8b045
Autor:
Jane Chanda Kabwe, Hirofumi Sawada, Yoshihide Mitani, Hironori Oshita, Naoki Tsuboya, Erquan Zhang, Junko Maruyama, Yoshiki Miyasaka, Hideyoshi Ko, Kazunobu Oya, Hiromasa Ito, Noriko Yodoya, Shoichiro Otsuki, Hiroyuki Ohashi, Ryuji Okamoto, Kaoru Dohi, Yuhei Nishimura, Tomoji Mashimo, Masahiro Hirayama, Kazuo Maruyama
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-22 (2022)
Abstract Background Patients with pulmonary arterial hypertension (PAH) carrying bone morphogenetic protein receptor type 2 (Bmpr2) mutations present earlier with severe hemodynamic compromise and have poorer survival outcomes than those without muta
Externí odkaz:
https://doaj.org/article/92a8518c4a4b459c8d7fad7b798a5a72
Autor:
Masako Kawai, Erquan Zhang, Jane Chanda Kabwe, Amphone Okada, Junko Maruyama, Hirofumi Sawada, Kazuo Maruyama
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Rats with chronic hypoxia-induced non-inflammatory pulmonary hypertension (PH) are resistant to ventilator-induced lung injury. We investigated the effect of high tidal volume ventilation in another model of PH, monocrotaline (MCT
Externí odkaz:
https://doaj.org/article/1e537076e92a4f41bb8ab98a649f7107
Autor:
Toshikazu Ito, Erquan Zhang, Ayaka Omori, Jane Kabwe, Masako Kawai, Junko Maruyama, Amphone Okada, Ayumu Yokochi, Hirofumi Sawada, Yoshihide Mitani, Kazuo Maruyama
Publikováno v:
BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background Preventing pulmonary vascular remodeling is a key strategy for pulmonary hypertension (PH). Causes of PH include pulmonary vasoconstriction and inflammation. This study aimed to determine whether cilostazol (CLZ), a phosphodiester
Externí odkaz:
https://doaj.org/article/c584309c6a5d45aaa3503139a0958425
Autor:
Shohko Sekine, Sayaka Mayama, Nobuaki Nishijima, Takuo Kojima, Yoko Endo-Takahashi, Yuko Ishii, Hitomi Shiono, Saki Akiyama, Akane Sakurai, Sanae Sashida, Nobuhito Hamano, Rui Tada, Ryo Suzuki, Kazuo Maruyama, Yoichi Negishi
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1665 (2023)
Strategies for gene and nucleic acid delivery to skeletal muscles have been extensively explored to treat Duchenne muscular dystrophy (DMD) and other neuromuscular diseases. Of these, effective intravascular delivery of naked plasmid DNA (pDNA) and n
Externí odkaz:
https://doaj.org/article/f46d1c15875344d78c0899d9609a3248
Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
Autor:
Chisato Kinoshita, Kazue Kikuchi-Utsumi, Koji Aoyama, Ryo Suzuki, Yayoi Okamoto, Nobuko Matsumura, Daiki Omata, Kazuo Maruyama, Toshio Nakaki
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Chisato Kinoshita et al. use a microbubble and ultrasound delivery system to inhibit miR-96-5p in the mouse brain. They demonstrate that miR96-5p regulates glutathione levels through the NOVA1 RNA binding protein, suggesting that this microRNA could
Externí odkaz:
https://doaj.org/article/4ec843332a5e4a27be302abc87f8c949
Autor:
Inoru Yokoe, Daiki Omata, Johan Unga, Ryo Suzuki, Kazuo Maruyama, Yoshiharu Okamoto, Tomohiro Osaki
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 530-541 (2021)
Pegylated liposomal doxorubicin (PLD) is a representative nanomedicine that has improved tumor selectivity and safety profile. However, the therapeutic superiority of PLD over conventional doxorubicin has been reported to be insignificant in clinical
Externí odkaz:
https://doaj.org/article/50dbe3acb5a44f42a24b542ab512aff0
Publikováno v:
Sensors & Transducers, Vol 246, Iss 7, Pp 64-70 (2020)
Blood clotting is measured by using a pressure sensor in a blood circuit, but the sensor doesn’t respond quick enough because the blood clotting can only be detected by an increase of the pressure caused by the clotting itself. This research is to
Externí odkaz:
https://doaj.org/article/69b15cef2882445296a4e81d7651199a
Autor:
Yusuke Yano, Nobuhito Hamano, Kenshin Haruta, Tomomi Kobayashi, Masahiro Sato, Yamato Kikkawa, Yoko Endo-Takahashi, Rui Tada, Ryo Suzuki, Kazuo Maruyama, Motoyoshi Nomizu, Yoichi Negishi
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 130 (2022)
A key challenge in treating solid tumors is that the tumor microenvironment often inhibits the penetration of therapeutic antibodies into the tumor, leading to reduced therapeutic efficiency. It has been reported that the combination of ultrasound-re
Externí odkaz:
https://doaj.org/article/f7ec3923966e4eb380fe57600f16ffe3
Publikováno v:
Sensors & Transducers, Vol 237, Iss 9-10, Pp 88-94 (2019)
Blood coagulation is measured by using a pressure sensor in a blood circuit, but it is not quick responsive because it is detected by pressure rise caused by coagulation. In this study, we have investigated a method to detect blood clotting at an ear
Externí odkaz:
https://doaj.org/article/60e25921585748b1b5351cb63f657969