Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Kazuo Honda"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 3, Pp 160-168 (2021)
We established a novel mouse model of chronic kidney disease (CKD) using acetic acid and compared it with the 5/6-nephrectomized mouse model. In our novel model, significant increases were observed in blood biochemical values and urinary parameters.
Externí odkaz:
https://doaj.org/article/13fff92c865a407d909b3ca5ddffe17c
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 1, Pp 99-106 (2014)
Abstract.: The present study compares gene expression and infarct area in a mouse model of embolic stroke after thrombolysis with t-PA and SMTP-7. Embolic occlusion was induced by transfer of acetic acid–induced embolus into the brain. t-PA or SMTP
Externí odkaz:
https://doaj.org/article/e66aba42bc314242aa9b8640a12b8748
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 1, Pp 41-49 (2010)
The aim of the present study was to establish a novel embolic model of cerebral infarction and to evaluate the effect of Stachybotrys microspora triprenyl phenol-7 (SMTP-7), a novel fungal triprenyl phenol metabolite. Thrombotic occlusion was induced
Externí odkaz:
https://doaj.org/article/d2f1778ef9654fcb9dd3b3ecdabef6d9
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 4, Pp 546-555 (2009)
The objective of this study was to compare intracellular calcium concentration ([Ca2+]i) and contractile responses in isolated rat middle cerebral artery (MCA) with those in basilar artery (BA) employing real-time confocal laser microscopy. KCl elici
Externí odkaz:
https://doaj.org/article/64d59692f4474bdb88c9e337686e5b9e
Autor:
Hiroshi Kawai, Takuo Suzuki, Tetsu Kobayashi, Akiko Ishii-Watabe, Haruna Sakurai, Hisayuki Ohata, Kazuo Honda, Kazutaka Momose, Takao Hayakawa, Toru Kawanishi
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 2, Pp 159-167 (2007)
The caspase activation cascade and mitochondrial changes are major biochemical reactions in the apoptotic cell death machinery. We attempted to clarify the temporal relationship between caspase activation, cytochrome c release, mitochondrial depolari
Externí odkaz:
https://doaj.org/article/5204b19b73cb489da5b4d138021a2fec
Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 1, Pp 82-87 (2006)
Abstract.: Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation
Externí odkaz:
https://doaj.org/article/6c209226170442fdaa5c39537b4f4b46
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 3, Pp 252-263 (2005)
Endothelial cell (EC) barrier dysfunction is associated with many types of vascular diseases. Investigators have hypothesized that altered EC contraction in conjunction with morphological changes may lead to EC dysfunction. However, the nature of EC
Externí odkaz:
https://doaj.org/article/ed89ebef22794eef8b4d2ae3d19d92f0
Autor:
Hiroshi Kawai, Takuo Suzuki, Tetsu Kobayashi, Haruna Sakurai, Hisayuki Ohata, Kazuo Honda, Kazutaka Momose, Iyuki Namekata, Hikaru Tanaka, Koki Shigenobu, Ryu Nakamura, Takao Hayakawa, Toru Kawanishi
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 3, Pp 361-368 (2005)
Fluorescence resonance energy transfer (FRET) with green fluorescent protein (GFP) variants has become widely used for biochemical research. In order to expand the choice of fluorescent range in FRET analysis, we designed various color versions of th
Externí odkaz:
https://doaj.org/article/43d6ebd1e59c4a6f8f9eec54544820e9
Autor:
Misa Yamada, Tomoko Iwabuchi, Kou Takahashi, Chika Kurahashi, Hisayuki Ohata, Kazuo Honda, Teruhiko Higuchi, Mitsuhiko Yamada
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 3, Pp 239-246 (2005)
The biological basis for the therapeutic mechanisms of depression are still unknown. While performing EST (expressed sequence tag) analysis to identify some molecular machinery responsible for the antidepressant effect, we determined the full-length
Externí odkaz:
https://doaj.org/article/d7cf964a7378418da0130fdd4c5cda6c
Publikováno v:
Biologicalpharmaceutical bulletin. 45(12)
SMTP-7, a fungal metabolite, is reported to have a high degree of availability for the ischemia-reperfusion (IR)-induced acute kidney injury (AKI) model. Cisplatin, a widely used anticancer drug, has serious side effects, such as AKI. Hence, we aimed