Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kazuo Okimoto"'
Autor:
Mami Kouchi, Yoshiko Michimae, Takatoshi Koujitani, Hitoshi Funabashi, Tomoaki Tochitani, Takaki Seki, Kaoru Toyosawa, Kazuo Okimoto, Izumi Matsumoto
Publikováno v:
Journal of Toxicologic Pathology
A female congenic rat produced by repeated backcrossing of Nihon rats, a model for hereditary renal cell carcinoma, to Brown Norway rats was necropsied at 24 months of age. At necropsy, a white mass about 1 centimeter in size was observed in the thor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ae6e21b06c52649e019a70c35d04c5
https://doi.org/10.1293/tox.25.41
https://doi.org/10.1293/tox.25.41
Autor:
Okio Hino, Yumiko Takagi, Toshiyuki Kobayashi, Lu Wang, Izumi Matsumoto, Masatoshi Shiono, Xianghua Piao, Yoshiaki Hagiwara, Danqing Zhang, Kazuo Okimoto, Mami Kouchi, Masaaki Abe, Guodong Sun
Publikováno v:
Biochemical and Biophysical Research Communications. 389:16-21
The Birt-Hogg-Dubé gene (BHD) encodes the tumor suppressor protein folliculin (FLCN). The function of FLCN has recently been implicated in the regulation of rapamycin-sensitive mTOR complex (mTORC1). Reciprocally, the mTORC1-dependent phosphorylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebd36ddd291c25f379eab9fedcc1f67
https://doi.org/10.1016/j.bbrc.2009.08.070
https://doi.org/10.1016/j.bbrc.2009.08.070
Autor:
Izumi Matsumoto, Kazuo Okimoto, Takaki Seki, Okio Hino, Tadashi Inoue, Tadayoshi Ueda, Kazuyasu Kijima, Mami Kouchi, Youko Hirayama
Publikováno v:
Tumor Biology. 30:249-256
A germline insertion of a single nucleotide in the rat homologue of the human Birt-Hogg-Dubé (BHD) gene gives rise to dominantly inherited renal cell carcinoma (RCC) in the Nihon rat model. In this study, we established 7 lines (NR cell lines NR22,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2475462bff42921f694dba7bcc7f9812
https://doi.org/10.1159/000243768
https://doi.org/10.1159/000243768
Autor:
Yoshiko Michimae, Toru Yamada, Toru Kimura, Takaki Seki, Tadashi Inoue, Mami Kouchi, Okio Hino, Masashi Yasuba, Kazuo Okimoto, Izumi Matsumoto
Publikováno v:
Experimental and Toxicologic Pathology. 59:273-279
Fibromatosis-type fibromas were found to develop at abdominal surgical sites in 4 heterozygous Nihon rats, a model for the human Birt–Hogg–Dube syndrome. In all 4 rats, solitary and firm nodules were located within the lateral abdominal musculatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6db823ec75fb3f181f1a2bf70565594
https://doi.org/10.1016/j.etp.2007.10.005
https://doi.org/10.1016/j.etp.2007.10.005
Publikováno v:
Journal of Toxicologic Pathology. 16:175-178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb0023f9cfdb17bbc55fd27038804eac
https://doi.org/10.1293/tox.16.175
https://doi.org/10.1293/tox.16.175
Autor:
Yoshiko Michimae, Izumi Matsumoto, Takaki Seki, Kazuo Okimoto, Takatoshi Koujitani, Shinichi Mikami, Kaoru Toyosawa, Mami Kouchi, Tadashi Inoue
Publikováno v:
Journal of Toxicologic Pathology
A male ferret, which was purchased from abroad at 9 months of age, had shown significant weight loss starting at 13 months of age. The ferret subsequently showed decreasing motor activity and recumbency and was euthanized at 14 months of age. At necr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c8b820b114d0b37c1fc130685ec113
http://europepmc.org/articles/PMC3234644
http://europepmc.org/articles/PMC3234644
Autor:
Mami Kouchi, Kaoru Toyosawa, Kazuo Okimoto, Nobuo Matsuoka, Junko Sakurai, Kohji Tanaka, Okio Hino, Emi Kikawa, Takatoshi Koujitani
Publikováno v:
Japanese Journal of Cancer Research : Gann
A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan, and named the rising "Nihon" rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 week
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddb0a128bb1e4581081a1a3b2192cc5
https://doi.org/10.1111/j.1349-7006.2000.tb00890.x
https://doi.org/10.1111/j.1349-7006.2000.tb00890.x
Publikováno v:
Journal of Toxicologic Pathology. 13:49-52
A mucinous adenocarcinoma was found in the jejunum of an untreated male F344 rat of 126 weeks old. The neoplasm was primarily composed of cuboidal to columnar goblet cells that were arranged in a glandular form. Alcian blue-PAS staining revealed muci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::464fdff42a9f173c18abfe7687474af8
https://doi.org/10.1293/tox.13.49
https://doi.org/10.1293/tox.13.49
Publikováno v:
Journal of Toxicologic Pathology. 8:435-439
This paper describes spontaneous ovarian choriocarcinoma in two B6C3F1 mice used in toxicity studies. One animal (case 1) was sacrificed at eight weeks of age, and the other one (case 2) was found dead at sixty-seven weeks of age. Macroscopically, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4e9bf206a5db8d9f93ddb7fe5d9d7aa
https://doi.org/10.1293/tox.8.435
https://doi.org/10.1293/tox.8.435
Autor:
Yoshiko Michimae, Hitoshi Funabashi, Kaoru Toyosawa, Mami Kouchi, Tomoaki Tochitani, Izumi Matsumoto, Kazuo Okimoto, Takatoshi Koujitani, Takaki Seki
Publikováno v:
Toxicologic pathology. 39(6)
Hyaline glomerulopathy with tubulo-fibrillary deposits was observed in two young female ddY mice. One of the mice showed gross systemic edema and bilateral enlargement and pale color of the kidneys, whereas no significant gross findings were noted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05970f4c2e934a56d0473baad99d9de9
https://pubmed.ncbi.nlm.nih.gov/21878553
https://pubmed.ncbi.nlm.nih.gov/21878553