Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Kazuo, Sakane"'
Autor:
Kouji, Hattori, Fujiko, Takamura, Akira, Tanaka, Hisashi, Takasugi, Kiyoshi, Taniguchi, Mie, Nishio, Satoshi, Koyama, Jiro, Seki, Kazuo, Sakane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3284-3287
A metabolism study of FR181157 (1) led to the discovery of new oxazole derivatives as active metabolites. The metabolite 6 with an epoxy ring exhibited high anti-aggregative potency with an IC(50) of 5.8 nM and potent binding affinity for the human r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc565e53a9c03d9516b3b2486ac467b
https://doi.org/10.1016/j.bmcl.2005.04.076
https://doi.org/10.1016/j.bmcl.2005.04.076
Autor:
Mie Nishio, Kouji Hattori, Masahide Higaki, Jiro Seki, Satoshi Koyama, Kiyoshi Taniguchi, Osamu Okitsu, Akira Tanaka, Seiichiro Tabuchi, Kazuo Sakane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3091-3095
The new classes of diphenylcarbamate derivatives with a tetrahydronaphthalene skeleton as highly potent and selective IP agonists have been discovered. The optimized diphenylcarbamate type compound FK-788: (R)-4 exhibited potent antiaggregative poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f98561b97697802f1557bf4c6b78b7
https://doi.org/10.1016/j.bmcl.2005.04.047
https://doi.org/10.1016/j.bmcl.2005.04.047
Autor:
Kazuo Sakane, Satoru Kuroda, Hiromichi Itani, Atsushi Akahane, Fujiko Takamura, Yasuyo Tomishima, Yoshiyuki Tenda
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 49:988-998
A novel series of 3-(2-substituted-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridines (5—38) were synthesized and evaluated for their in vitro adenosine A1 and A2A receptor binding activities, and in vitro metabolism by rat liver in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a50230e34ef837d9d0c35589252c6b9c
https://doi.org/10.1248/cpb.49.988
https://doi.org/10.1248/cpb.49.988
Publikováno v:
Japanese Journal of Pharmacology. 85:175-182
The anti-inflammatory and ulcerogenic effects of FR188582, 3-chloro-5-[4-(methylsulfonyl) phenyl]-1-phenyl-1H-pyrazole, were investigated. In a recombinant human cyclooxygenase (COX) enzyme activity, FR188582 inhibited COX-2 with an IC50 value of 0.0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46b7ffd15781ec3450a69914004c6ce
https://doi.org/10.1254/jjp.85.175
https://doi.org/10.1254/jjp.85.175
Autor:
Kouji Hattori, Hirokazu Tanaka, Kazunori Tsubaki, Kazuo Sakane, Seiichiro Tabuchi, Kiyoshi Taniguchi, Osamu Okitsu, Jiro Seki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2787-2790
A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI 2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC 50 value of 0.081 μM and has high oral bioavailability (56%) with a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe36c706a69c2af83e79b4ae635e2e1
https://doi.org/10.1016/s0960-894x(00)00571-0
https://doi.org/10.1016/s0960-894x(00)00571-0
Autor:
Tetsuo Tomishi, Hirohumi Ishikawa, Yousuke Katsura, Hisashi Takasugi, Kazuo Sakane, Yoshimi Matsumoto, Yoshikazu Inoue, Chizu Morinaga
Publikováno v:
Journal of Medicinal Chemistry. 43:3315-3321
In order to find a new class of anti-Helicobacter pylori (H. pylori) agents, a series of 4-[(3-acetamido)phenyl]-2-(substituted guanidino)thiazoles and some structurally rigid analoges were synthesized and evaluated for antimicrobial activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd1993bcd427d84c26a440389f5f1aa
https://doi.org/10.1021/jm000169n
https://doi.org/10.1021/jm000169n
Autor:
Takeshi Terasawa, Kohji Kawabata, Hirofumi Yamamoto, Satoru Matsumoto, Shuichi Tawara, Kazuo Sakane, Ayako Nakamura, Yoshimi Matsumoto
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:1159-1170
A series of 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamid o]cephalosporins having a pyridine ring connected through various spacer moieties at the C-3 position was designed and synthesized and evaluated for antibacterial activity and oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166ec599315e05ecd44906820568e07b
https://doi.org/10.1016/s0968-0896(00)00021-3
https://doi.org/10.1016/s0968-0896(00)00021-3
Autor:
Kazumi Otomo, Noriko Teratani, Katsuyuki Maki, Akira Yamada, Hidenori Ohki, Hisashi Takasugi, Yoshihiko Morishita, Masaki Tomishima, Hirokazu Tanaka, Fumiaki Ikeda, Koji Kawabata, Fumio Matsumoto, Shogo Kuwahara, Toshio Goto, Shuichi Tawara, Kazuo Sakane
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:57-62
The currently available antifungal drugs for the treatment of deep-seated mycoses are limited to amphotericin B (AMPH-B), azole compounds, and flucytosine. AMPH-B remains the drug of choice for the treatment of most fungal diseases because it has bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fffc6c1174759bac2ad17086f254441
https://doi.org/10.1128/aac.44.1.57-62.2000
https://doi.org/10.1128/aac.44.1.57-62.2000
Autor:
Kazuo Sakane, Atsushi Akahane, Satoru Kuroda, Takayoshi Kinoshita, Isao Nakanishi, Kieran Durkin, Shintaro Nishimura, Hiromichi Itani
Publikováno v:
Tetrahedron. 55:10351-10364
An efficient synthesis of FR166124 ( 1 ) was achieved through a novel sequential Horner-Emmons -isomerization reaction of cyclohexanone ( 2 ) with tert -butyl diethylphosphonoacetate ( 3 ) as the key process. Extensive studies of the key reaction ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4424a2ff994b49b2b7066d6421c9eba6
https://doi.org/10.1016/s0040-4020(99)00590-6
https://doi.org/10.1016/s0040-4020(99)00590-6
Autor:
Yousuke Katsura, Mitsuko Ohno, Hirohumi Ishikawa, Kazuo Sakane, Shigetaka Nishino, Chizu Morinaga, Hisashi Takasugi, Yoshimi Matsumoto
Publikováno v:
Journal of Medicinal Chemistry. 42:2920-2926
A series of 2-[(arylalkyl)guanidino]-4-[(5-acetamidomethyl)furan-2-yl]thiazole s and some 4-acetamidomethyl positional isomers were synthesized and evaluated for antimicrobial activity against Helicobacter pylori. Among the compounds that had potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3a6961206a99be453a2a762c6eaf64
https://doi.org/10.1021/jm9900671
https://doi.org/10.1021/jm9900671