Zobrazeno 1 - 10
of 417
pro vyhledávání: '"Kazuo, Nagasawa"'
In this book, key experts in the field of total synthesis of natural products in Japan describe the details of their synthesis routes including unexpected reactions and syntheses. By presenting detailed stories behind the total synthesis developments
Autor:
Miho Iwaki, Yoshiaki Kanemoto, Takahiro Sawada, Koki Nojiri, Tomohiro Kurokawa, Rino Tsutsumi, Kazuo Nagasawa, Shigeaki Kato
Publikováno v:
PLoS ONE, Vol 18, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/5299effddd854eba80a6dd93c315d038
Autor:
Yuka Mizumoto, Ryota Sakamoto, Kazuto Iijima, Naoto Nakaya, Minami Odagi, Masayuki Tera, Takatsugu Hirokawa, Toshiyuki Sakaki, Kaori Yasuda, Kazuo Nagasawa
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1036 (2023)
Vitamin D3 (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin D3 (6a) and 4β,25-dihydroxyvitamin D3 (6b) are both produced from 25-hydroxyvitamin D3 (2)
Externí odkaz:
https://doaj.org/article/c5b86fd457e040e49e31682f095f8413
Autor:
Akiko Nagata, Kazuto Iijima, Ryota Sakamoto, Yuka Mizumoto, Miho Iwaki, Masaki Takiwaki, Yoshikuni Kikutani, Seketsu Fukuzawa, Minami Odagi, Masayuki Tera, Kazuo Nagasawa
Publikováno v:
Molecules, Vol 27, Iss 8, p 2427 (2022)
Blood levels of the vitamin D3 (D3) metabolites 25-hydroxyvitamin D3 (25(OH)D3), 24R,25-dihydroxyvitamin D3, and 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) are recognized indicators for the diagnosis of bone metabolism-related diseases, D3 deficiency-r
Externí odkaz:
https://doaj.org/article/d2238d20565c4872998ea88502ec583d
Publikováno v:
ACS Catalysis. 13:2295-2301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1fc533c115597bb00e26af0382e4a20
https://doi.org/10.1021/acscatal.2c05677
https://doi.org/10.1021/acscatal.2c05677
Autor:
Kazuo Nagasawa, Minami Odagi
Publikováno v:
Synlett. 34:1087-1097
Alkaloids with fused polycyclic frameworks are attractive targets for synthetic organic chemists because of their structural complexity and biological activities, and a variety of strategies for their synthesis have been developed. Herein, we describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e94052386384b27ffcfe2da877d6c2
https://doi.org/10.1055/a-2007-9342
https://doi.org/10.1055/a-2007-9342
Autor:
Yuka Mizumoto, Ryota Sakamoto, Akiko Nagata, Suzuka Sakane, Atsushi Kittaka, Minami Odagi, Masayuki Tera, Kazuo Nagasawa
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 69 (2022)
The active form of vitamin D3 (D3), 1a,25-dihydroxyvitamn D3 (1,25D3), plays a central role in calcium and bone metabolism. Many structure–activity relationship (SAR) studies of D3 have been conducted, with the aim of separating the biological acti
Externí odkaz:
https://doaj.org/article/aaba203519014043a1a5377b11ad9e7d
Autor:
Antonio Porro, Matteo Berti, Julia Pizzolato, Serena Bologna, Svenja Kaden, Anja Saxer, Yue Ma, Kazuo Nagasawa, Alessandro A. Sartori, Josef Jiricny
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
FANCD2-associated nuclease 1 (FAN1) is a key protein involved in the metabolism of DNA and in human pathologies. Here, the authors show that FAN1 directly interacts with PCNA at stalled replication forks to control their progression and prevent their
Externí odkaz:
https://doaj.org/article/242ed121c6a24d50ab52a5d2eada5647
Autor:
Takahiro Nakamura, Sachiko Okabe, Haruka Yoshida, Keisuke Iida, Yue Ma, Shogo Sasaki, Takao Yamori, Kazuo Shin-ya, Ichiro Nakano, Kazuo Nagasawa, Hiroyuki Seimiya
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract G-quadruplex (G4) is a higher-order nucleic acid structure that is formed by guanine-rich sequences. G4 stabilization by small-molecule compounds called G4 ligands often causes cytotoxicity, although the potential medicinal impact of this ef
Externí odkaz:
https://doaj.org/article/3aa433890e6a4fbf9414876c5f696dba
Publikováno v:
Chemistry Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80642ba3c99efdced24fea484d3120f2
https://doi.org/10.1246/cl.230106
https://doi.org/10.1246/cl.230106