Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Kazuo, Kajita"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 932 (2024)
One of the major global health and welfare issues is the treatment of obesity and associated metabolic disorders, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease. Obesity, caused by the excessive accumulation of triglycerides in
Externí odkaz:
https://doaj.org/article/be17a0c4b6c14bc48023941446327290
Autor:
Motochika Asano, Kazuo Kajita, Masayuki Fuwa, Toshiko Kajita, Ichiro Mori, Noriyuki Akahoshi, Isao Ishii, Hiroyuki Morita
Publikováno v:
Endocrinology. 164
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that regulates fundamental cellular processes such as proliferation, migration, apoptosis, and differentiation through 5 cognate G protein–coupled receptors (S1P1-S1P5). We previously demons
Autor:
Takahide Ikeda, Hiroyuki Morita, Motochika Asano, Yuichi Hayashi, Yoshihiko Kitada, K. Taguchi, Kazuo Kajita
Publikováno v:
Internal Medicine
A 25-year-old woman had convulsions and disturbance of consciousness. Head magnetic resonance imaging (MRI) showed punctate areas in the occipital lobes with increased signals on T2-weighted imaging. The MRI abnormalities responded well to steroid pu
Autor:
Itaru Kojima, Hiroyuki Morita, Yoshihiko Kitada, Kazuo Kajita, Koichiro Taguchi, Takahide Ikeda, Toshiko Kajita, Tatsuo Ishizuka, Motochika Asano, Masayuki Fuwa
Publikováno v:
The Journal of Endocrinology
Despite extensive investigation, the mechanisms underlying adipogenesis are not fully understood. We previously identified proliferative cells in adipose tissue expressing adipocyte-specific genes, which were named small proliferative adipocytes (SPA
Autor:
Takahide Ikeda, Tatsuo Ishizuka, Koichiro Taguchi, Masayuki Fuwa, Hiroyuki Morita, Kazuo Kajita
Publikováno v:
Diabetes. 69
RE1-silencing transcription factor (REST) is a transcriptional factor which negatively regulates the expression of numerous neuronal genes. In this study, model mice lacking REST in adipocytes were generated to investigate the role of REST in adipocy
Publikováno v:
International Journal of Clinical Endocrinology and Metabolism. :004-007
Case 1: A 65- year-old man was accidentally injured by wooden hammer on his top of head on 34 years before. He was suffered from vomiting, diarrhea and hypotension, and the laboratory examination revealed increased CRP level, hyponatremia and decreas
Autor:
Tatsuo Ishizuka, Yoshihiko Kitada, Masayuki Fuwa, Kazuo Kajita, Takahide Ikeda, Koichiro Taguchi, Hiroyuki Morita
Publikováno v:
Diabetes. 68
We have reported that several neuronal genes, glutamate receptor 7 and synuclein γ, are expressed in adipocytes. Since the individual roles of these neuronal genes are different, it is unlikely that these genes carry out any common functions togethe
Autor:
Daisuke Murakami, Yoshihiko Kitada, Kazuo Kajita, Hideyuki Okada, Mikako Kawashima, Ichiro Mori, Tatsuo Ishizuka, Hiroyuki Morita
Publikováno v:
Diabetes. 68
Insulin is often administered for glucocorticoid (GC) -induced hyperglycemia. We have developed and validated a scoring system to predict insulin requirement for optimal control of hyperglycemia during GC treatment through retrospective studies. The
Autor:
Motochika Asano, Shotaro Kamata, Yoshiko Banno, Toshiko Kajita, Ichiro Mori, Itaru Kojima, Isao Ishii, Tatsuo Ishizuka, Masahiro Yamauchi, Hiroyuki Morita, Mikako Kawashima, Jerold Chun, Takahide Ikeda, Yoshihiko Kitada, Koichiro Taguchi, Kazuo Kajita
Publikováno v:
Endocrinology. 157:1839-1851
Sphingosine 1-phosphate (S1P) is known to regulate insulin resistance in hepatocytes, skeletal muscle cells, and pancreatic β-cells. Among its 5 cognate receptors (S1pr1–S1pr5), S1P seems to counteract insulin signaling and confer insulin resistan
Autor:
Motochika Asano, Tatsuo Ishizuka, Yoshihiko Kitada, Masayuki Fuwa, Koichiro Taguchi, Takahide Ikeda, Kazuo Kajita, Hiroyuki Morita
Publikováno v:
Diabetes. 67
We previously identified proliferative cells in adipose tissue expressing adipocyte specific genes and preadipocyte specific genes, which were named small proliferative adipocytes (SPA). Furthermore, we found that SPA specifically express proliferin