Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Kazunori Yoneda"'
Autor:
Kazunori Yoneda, Ryo Kanada, Jun-ichi Okada, Masahiro Watanabe, Seiryo Sugiura, Toshiaki Hisada, Takumi Washio
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Changes in intracellular calcium concentrations regulate heart beats. However, the decline in the left ventricular pressure during early diastole is much sharper than that of the Ca2+ transient, resulting in a rapid supply of blood to the left ventri
Externí odkaz:
https://doaj.org/article/83be58bd9cf0495e822b3e3adda955e5
Autor:
Kazunori Yoneda, Jun-ichi Okada, Masahiro Watanabe, Seiryo Sugiura, Toshiaki Hisada, Takumi Washio
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
In a multiscale simulation of a beating heart, the very large difference in the time scales between rapid stochastic conformational changes of contractile proteins and deterministic macroscopic outcomes, such as the ventricular pressure and volume, h
Externí odkaz:
https://doaj.org/article/655ed24c998d41eb924dbb0a1577eb97
Autor:
Takashi Iwamura, Seiryo Sugiura, Akihiro Isotani, Masahiro Watanabe, Takumi Washio, Kazunori Yoneda, Jun-ichi Okada, Kenji Ando, Toshiaki Hisada
Publikováno v:
Heart and Vessels
To identify non-responders to cardiac resynchronization therapy (CRT), various biomarkers have been proposed, but these attempts have not been successful to date. We tested the clinical applicability of computer simulation of CRT for the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fcfded4e4a5e474ed347fc475852a69
https://doi.org/10.1007/s00380-020-01577-1
https://doi.org/10.1007/s00380-020-01577-1
Autor:
Issei Komuro, Kazunori Yoneda, Katsuhiko Fujiu, Toshiaki Hisada, Takashi Iwamura, Takumi Washio, Jun-ichi Okada, Seiryo Sugiura
Publikováno v:
The Journal of Physiological Sciences. 70
ST elevation on an electrocardiogram is a hallmark of acute transmural ischemia. However, the underlying mechanism remains unclear. We hypothesized that high ischemic sensitivities of epicardial adenosine triphosphate-sensitive potassium (IKATP) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21af173ad56326c24d5d1690d960377
https://doi.org/10.1186/s12576-020-00760-3
https://doi.org/10.1186/s12576-020-00760-3
Autor:
Jun-Ichi Okada, Katsuhiko Fujiu, Kazunori Yoneda, Takashi Iwamura, Takumi Washio, Issei Komuro, Toshiaki Hisada, Seiryo Sugiura
Publikováno v:
Journal of Physiological Sciences; 2020, Vol. 70 Issue 1, p1-14, 14p
Autor:
Yoshimasa Kadooka, Toshiaki Hisada, Akihito Takahashi, Takumi Washio, Kazunori Yoneda, Seiryo Sugiura, Jun-ichi Okada
Publikováno v:
Multiscale Modeling & Simulation. 11:965-999
In this paper, we introduce a multiscale heart simulation method that integrates the three-scale phenomena from the microscopic stochastic sarcomere kinetics to the macroscopic heartbeat via the mesoscopic myocardial cell assembly. In sarcomere kinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2783f3210130b1c0df910073313001f
https://doi.org/10.1137/120892866
https://doi.org/10.1137/120892866
Autor:
Tokio Osaki, Tetsuya Yamamoto, Yukihiro Tatemoto, Takeshi Yokoyama, Kazunori Yoneda, Hideaki Enzan
Publikováno v:
International Journal of Experimental Pathology. 82:231-241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0299c6ac16b5f6ef98c16ecdc03dedaa
https://doi.org/10.1111/j.1365-2613.2001.iep193.x
https://doi.org/10.1111/j.1365-2613.2001.iep193.x
Publikováno v:
Japanese Journal of Pharmacology. 87:41-50
To explore the mechanism of pulmonary fibrosis by bleomycin and its derivative, peplomycin (PLM), we examined the influence of PLM on signal transduction in human peripheral blood lymphocytes (HL), monocytes (HM) and fibroblasts (HF). Tyrosine phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee4559a943855dc2f60569c027b4fcf
https://doi.org/10.1254/jjp.87.41
https://doi.org/10.1254/jjp.87.41
Publikováno v:
European Journal of Cancer. 36:2007-2017
Induction of potent apoptosis is required in cancer therapy. We examined the combination effect of interleukin-2-activated lymphocytes (LAK cells) and anticancer drugs or gamma (gamma)-rays on the induction of apoptosis in an established oral squamou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9114e8652243eae12521da8008efac1
https://doi.org/10.1016/s0959-8049(00)00244-6
https://doi.org/10.1016/s0959-8049(00)00244-6
Autor:
Lu Dapeng, Tsuyoshi Kimura, Kazunori Yoneda, Tetsuya Yamamoto, Tokio Osaki, Yukihiro Tatemoto
Publikováno v:
Oncology. 59:36-43
Lack of control of metastatic foci is the most prevalent cause of death in patients with oral carcinomas, and it is important for tumor control to identify the factors that predispose patients to death. In the present study, we examined 225 patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae02126db76db07e662d7df5e08e80f1
https://doi.org/10.1159/000012135
https://doi.org/10.1159/000012135