Výsledky vyhledávání - "Kazunori Uegaki"

Activation of the Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway Overcomes Cisplatin Resistance in Ovarian Carcinoma Cells

Autor: Wakae Kawaguchi, Hiroaki Itamochi, Jun Naniwa, Tetsuro Oishi, Junzo Kigawa, Akiko Kudoh, Michiko Nonaka, Seiya Sato, Kazunori Uegaki, Naoki Terakawa, Shinya Sato, Muneaki Shimada, Tasuku Harada

Publikováno v: International Journal of Gynecologic Cancer. 22:922-929

ObjectiveThis study was aimed to elucidate the roles of the mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3′-kinase (PI3K)/Akt pathways in regulating cytotoxicity induced by cispl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e29dcae4ddbc6dfdd99405b66a13097
https://doi.org/10.1097/igc.0b013e31824f0b13

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Combination chemotherapy of oxaliplatin and 5-fluorouracil may be an effective regimen for mucinous adenocarcinoma of the ovary: A potential treatment strategy

Autor: Tetsuro Oishi, Michiko Nonaka, Kazunori Uegaki, Junzo Kigawa, Hiroaki Itamochi, Jun Naniwa, Naoki Terakawa, Muneaki Shimada, Shinya Sato, Seiya Sato

Publikováno v: Cancer Science. 100:546-551

Resistance of ovarian mucinous adenocarcinoma to standard chemotherapy with paclitaxel and carboplatin is associated with poor prognosis, and an effective treatment is needed. The present study aimed to identify an effective chemotherapy for ovarian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8d45d0cfcc0952fe38390afa7229e1
https://doi.org/10.1111/j.1349-7006.2008.01065.x

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PTEN is involved in the signal transduction pathway of contact inhibition in endometrial cells

Autor: Muneaki Shimada, Wakae Kawaguchi, Hiroaki Itamochi, Kazunori Uegaki, Tetsuro Oishi, Yasunobu Kanamori, Masakuni Takahashi, Naoki Terakawa, Junzo Kigawa, Ruri Kaneko, Jun Naniwa

Publikováno v: Cell and Tissue Research. 323:523-528

PTEN is involved in the regulation of normal cellular functions in addition to its well-known role as a tumor suppressor. In the present study, we have shown that stable transfection of the PTEN gene into PTEN-mutated endometrial carcinoma cells lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2c461506705b5a775c1dbc35c852e0
https://doi.org/10.1007/s00441-005-0082-3

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Expression of the c-myc gene as a predictor of chemotherapy response and a prognostic factor in patients with ovarian cancer

Autor: Yasunobu Kanamori, Muneaki Simada, Naoki Terakawa, Hiroaki Itamochi, Takahiro Iba, Kazunori Uegaki, Tetsuro Oishi, Jun Naniwa, Junzo Kigawa

Publikováno v: Cancer Science. 95:418-423

The present study was conducted to determine whether and how expression of the c-myc gene is related to the response to chemotherapy in patients with epithelial ovarian cancer. This study includes 101 consecutive patients with stage Ic to IV epitheli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfecbe9ec1b581d13c838f77aa52e7de
https://doi.org/10.1111/j.1349-7006.2004.tb03225.x

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Outcome of stage IB2-IIB patients with bulky uterine cervical cancer who underwent neoadjuvant chemotherapy followed by radical hysterectomy

Autor: Imari Deura, Junzo Kigawa, Tetsuro Oishi, Tasuku Harada, Kazunori Uegaki, Seiya Sato, Hiroaki Itamochi, Muneaki Shimada, Jun Naniwa, Shinya Sato

Publikováno v: International journal of clinical oncology. 19(2)

We performed a retrospective study to clarify the outcome of stage IB2–IIB patients with bulky cervical cancer who underwent neoadjuvant chemotherapy (NAC) followed by radical hysterectomy and adjuvant treatment. Sixty-five patients with bulky stag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76eb911afd446d60ddfa3b363ebdbc6a
https://pubmed.ncbi.nlm.nih.gov/23592280

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Inhibiting the mTOR pathway synergistically enhances cytotoxicity in ovarian cancer cells induced by etoposide through upregulation of c-Jun

Autor: Muneaki Shimada, Jun Naniwa, Tetsuro Oishi, Tasuku Harada, Shinya Sato, Junzo Kigawa, Naoki Terakawa, Hiroaki Itamochi, Michiko Nonaka, Kazunori Uegaki, Seiya Sato

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 17(14)

Purpose: The mTOR pathway is thought to be a central regulator of proliferation and survival of cells. Rapamycin and its analogs are undergoing clinical trials in patients with epithelial ovarian cancer. This study aimed to assess the potential to us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e4a12b13627ceb71192032a08ac8ba
https://pubmed.ncbi.nlm.nih.gov/21610153

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Preoperative and intraoperative assessments of depth of myometrial invasion in endometrial cancer

Autor: Toshihide Ogawa, Michiko Nonaka, Hiroaki Itamochi, Shinya Sato, Shinya Fujii, Junzo Kigawa, Seiya Sato, Kazunori Uegaki, Jun Naniwa, Muneaki Shimada

Publikováno v: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 19(5)

Objective: Preoperative and intraoperative assessments of myometrial invasion (MI) are commonly used for planning surgical procedures such as dissection of the para-aortic node; however, the assessments often differ from the final diagnosis determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14590645b15b0e72ab05d2efcafbcfe3
https://pubmed.ncbi.nlm.nih.gov/19574778

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PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma

Autor: Muneaki Shimada, Naoki Terakawa, Hiroaki Itamochi, Masakuni Takahashi, Tetsuro Oishi, Junzo Kigawa, Kazunori Uegaki, Yasunobu Kanamori, Wakae Kawaguchi, Ruri Kaneko, Jun Naniwa

Publikováno v: Oncology reports. 14(2)

PTEN and the PI3K/Akt pathway are involved in the development and/or progression of endometrial carcinoma. To clarify the impact of the pathway-related molecules on prognosis, we analyzed PTEN, phosphorylated-Akt (p-Akt), and Ki-67 expression by immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cfa36ba483fd4021d32943e89727b5
https://pubmed.ncbi.nlm.nih.gov/16012720

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Activity of docetaxel in paclitaxel-resistant ovarian cancer cells

Autor: Muneaki Shimada, Kazunori Uegaki, Jun Naniwa, Naoki Terakawa, Tetsuro Oishi, Shinya Sato, Yasunobu Kanamori, Hiroaki Itamochi, Takahiro Iba, Junzo Kigawa

Publikováno v: Cancer chemotherapy and pharmacology. 53(3)

The aim of this study was to determine the behavior of docetaxel (DTX) in ovarian cancer cells resistant to paclitaxel (PTX).We used human ovarian adenocarcinoma cell lines KF, KFTx (PTX-resistant KF), SK-OV-3, and HAC-2. The sensitivity of the cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e082a46184761bfa33f19d5cf249a175
https://pubmed.ncbi.nlm.nih.gov/14610615

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