Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Kazunori Tomita"'
Autor:
Laura C. Collopy, Tracy L. Ware, Tomas Goncalves, Sunnvør í Kongsstovu, Qian Yang, Hanna Amelina, Corinne Pinder, Ala Alenazi, Vera Moiseeva, Siân R. Pearson, Christine A. Armstrong, Kazunori Tomita
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.
Externí odkaz:
https://doaj.org/article/2f530556f00745c9b6030e3daa173ab6
Publikováno v:
Open Biology, Vol 7, Iss 3 (2017)
Aberrant activation of telomerase occurs in 85–90% of all cancers and underpins the ability of cancer cells to bypass their proliferative limit, rendering them immortal. The activity of telomerase is tightly controlled at multiple levels, from tran
Externí odkaz:
https://doaj.org/article/737798b2eb9c44f5ae27c9ec1eec5496
Autor:
Sebastian R. Schreglmann, Tomas Goncalves, Melissa Grant‐Peters, Demis A. Kia, Lilach Soreq, Mina Ryten, Nicholas W. Wood, Kailash P. Bhatia, Kazunori Tomita
Data Availability Statement: The raw data that support the findings of this study are available from the corresponding authors upon reasonable request. Demographic and clinical details of human control spleen-brain tissue donors used in this study ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402d2fa64dd54d7a657955778826929f
https://bura.brunel.ac.uk/handle/2438/26374
https://bura.brunel.ac.uk/handle/2438/26374
Autor:
Detlef Bockenhauer, François Dragon, Christelle Arrondel, Ákos Szekeres, Kristóf Perczel, Wei-Li Di, Susanne Motameny, Attila Fintha, Maria Kolatsi-Joannou, Eszter Jávorszky, Guillaume Dorval, Salah Marzouk, Kazunori Tomita, Jennifer C. Chandler, Peter Nürnberg, Gusztáv Schay, Veronica A. Kinsler, Ahmed Hossain, Andrea Kerti, András Perczel, Hafsa Hammid, Magdolna Kardos, William Mifsud, Florentina Sava, David Curtis, Corinne Antignac, Felipe D’Arco, Aoife M. Waters, Géraldine Mollet, Mona Tahoun, Gergely Toldi, Tivadar Tulassay, Ana Faro, Anna Szőcs, Jutta Koeglmeier, Kata Kelen, Marwa H. Saied, Holger Thiele, Hywel Williams, Kálmán Tory, Renáta Hamar, Erika Maka, Mario Kaliakatsos, Mariya Moosajee, Gábor Rudas, Máté Varga, Eszter Balogh, Attila Szabo, Dóra K. Menyhárd, Horia Stanescu, Tomas Goncalves, Olivier Gribouval, Regina Légrádi, George S. Reusz, Robert Kleta, Judit Götze, David A. Long
Publikováno v:
Proceedings of the National Academy of Sciences. 117:15137-15147
RNA modifications play a fundamental role in cellular function. Pseudouridylation, the most abundant RNA modification, is catalyzed by the H/ACA small ribonucleoprotein (snoRNP) complex that shares four core proteins, dyskerin (DKC1), NOP10, NHP2, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c70950ec857554bf1e04d93236b91c
https://doi.org/10.1073/pnas.2002328117
https://doi.org/10.1073/pnas.2002328117
Autor:
Tomas Goncalves, Georgia Zoumpoulidou, Carlos Alvarez-Mendoza, Caterina Mancusi, Laura C. Collopy, Sandra J. Strauss, Sibylle Mittnacht, Kazunori Tomita
The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsptsci.0c00125. Origin and characteristics of the osteosarcoma cell lines, telomere length measurement from TRF, IC50 drug response in osteosarcoma cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446fe52d87a9d9046678ffd9d18f924f
https://bura.brunel.ac.uk/handle/2438/21626
https://bura.brunel.ac.uk/handle/2438/21626
Autor:
Laura C. Collopy, Carlos Alvarez-Mendoza, Sibylle Mittnacht, Kazunori Tomita, Caterina Mancusi, Sandra J. Strauss, Tomas Goncalves, Georgia Zoumpoulidou
Publikováno v:
ACS Pharmacology & Translational Science
To avoid replicative senescence or telomere-induced apoptosis, cancers employ telomere maintenance mechanisms (TMMs) involving either the upregulation of telomerase or the acquisition of recombination-based alternative telomere lengthening (ALT). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd0757e602bbdeecd4527f4296816a1
https://pubmed.ncbi.nlm.nih.gov/33344901
https://pubmed.ncbi.nlm.nih.gov/33344901
Autor:
Eszter, Balogh, Jennifer C, Chandler, Máté, Varga, Mona, Tahoun, Dóra K, Menyhárd, Gusztáv, Schay, Tomas, Goncalves, Renáta, Hamar, Regina, Légrádi, Ákos, Szekeres, Olivier, Gribouval, Robert, Kleta, Horia, Stanescu, Detlef, Bockenhauer, Andrea, Kerti, Hywel, Williams, Veronica, Kinsler, Wei-Li, Di, David, Curtis, Maria, Kolatsi-Joannou, Hafsa, Hammid, Anna, Szőcs, Kristóf, Perczel, Erika, Maka, Gergely, Toldi, Florentina, Sava, Christelle, Arrondel, Magdolna, Kardos, Attila, Fintha, Ahmed, Hossain, Felipe, D'Arco, Mario, Kaliakatsos, Jutta, Koeglmeier, William, Mifsud, Mariya, Moosajee, Ana, Faro, Eszter, Jávorszky, Gábor, Rudas, Marwa H, Saied, Salah, Marzouk, Kata, Kelen, Judit, Götze, George, Reusz, Tivadar, Tulassay, François, Dragon, Géraldine, Mollet, Susanne, Motameny, Holger, Thiele, Guillaume, Dorval, Peter, Nürnberg, András, Perczel, Attila J, Szabó, David A, Long, Kazunori, Tomita, Corinne, Antignac, Aoife M, Waters, Kálmán, Tory
Publikováno v:
Proc Natl Acad Sci U S A
RNA modifications play a fundamental role in cellular function. Pseudouridylation, the most abundant RNA modification, is catalyzed by the H/ACA small ribonucleoprotein (snoRNP) complex that shares four core proteins, dyskerin (DKC1), NOP10, NHP2, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed9767392e180665c2cb7a1e6caf982d
https://pubmed.ncbi.nlm.nih.gov/32554502
https://pubmed.ncbi.nlm.nih.gov/32554502
Autor:
Kazunori Tomita, Laura C. Collopy
Publikováno v:
Oxford Textbook of Cancer Biology
The lifetime of a cell is set by the terminal ends of our chromosomes, ageing timers called telomeres. Most dividing cells, not exceptional for cancers, require telomeres to protect chromosomes. However, telomere erosion occurs at every cell cycle, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::266b4161d6a1f4db427ef449fb3bbb4e
https://doi.org/10.1093/med/9780198779452.003.0015
https://doi.org/10.1093/med/9780198779452.003.0015
Autor:
Cassandra Backes, Tobias von der Haar, Tristan Espie--Caullet, Evgeniy R. Galimov, Celia Lujan, Saul Moore, Victoria Eugenia Martinez-Miguel, Daniel Martinez-Martinez, Suam Gonzalez, Charalampos Rallis, Mario Halic, Filipe Cabreiro, Kazunori Tomita, Ivana Bjedov, André Ex Brown
Publikováno v:
Cell Metabolism
Mol Cell
2300.e12
Mol Cell
2300.e12
Summary Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the accuracy of translation, yet the physiological consequence of having fewer protein synthesis errors during multi-cellular organismal aging is poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f87cc19ede7b78f7f37c50ba9a7cd40
http://europepmc.org/articles/PMC8570412
http://europepmc.org/articles/PMC8570412
Autor:
Masafumi Tsurumi, Hirotake Okazaki, Takuro Shinada, Nobuaki Kobayashi, Kuniya Asai, Wataru Shimizu, Kazunori Tomita, Masato Matsushita, Yoshiya Yamamoto, Akihiro Shirakabe, Noritake Hata
Publikováno v:
Heart and Vessels. 32:600-608
Obesity is known to be associated with the development of heart failure (HF). However, the relationship between the body mass index (BMI) and acute HF (AHF) remains to be elucidated. Eight hundred and eight AHF patients were enrolled in this study. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a15a6d6dcc64722e8af1c0ab887b34
https://doi.org/10.1007/s00380-016-0908-9
https://doi.org/10.1007/s00380-016-0908-9