Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Kazunori Kawamura"'
Autor:
Kiwamu Matsuoka, Kosei Hirata, Naomi Kokubo, Takamasa Maeda, Kenji Tagai, Hironobu Endo, Keisuke Takahata, Hitoshi Shinotoh, Maiko Ono, Chie Seki, Harutsugu Tatebe, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado
Publikováno v:
NeuroImage: Clinical, Vol 41, Iss , Pp 103560- (2024)
In Alzheimer’s disease (AD), aggregated abnormal proteins induce neuronal dysfunction. Despite the evidence supporting the association between tau proteins and brain atrophy, further studies are needed to explore their link to neuronal dysfunction
Externí odkaz:
https://doaj.org/article/e8deeb2471ab4de6915f76e8acd8bb04
Autor:
Kazunori Kawamura, Tomoteru Yamasaki, Masayuki Fujinaga, Tomomi Kokufuta, Yiding Zhang, Wakana Mori, Yusuke Kurihara, Masanao Ogawa, Kaito Tsukagoe, Nobuki Nengaki, Ming-Rong Zhang
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Background A family of BF2-chelated tetraaryl-azadipyrromethenes was developed as non-porphyrin photosensitizers for photodynamic therapy. Among the developed photosensitizers, ADPM06 exhibited excellent photochemical and photophysical prope
Externí odkaz:
https://doaj.org/article/d20f980a5b7a4b4bb6a51900c7430e02
Autor:
Kenji Tagai, Yoko Ikoma, Hironobu Endo, Oiendrila Bhowmik Debnath, Chie Seki, Kiwamu Matsuoka, Hideki Matsumoto, Masaki Oya, Kosei Hirata, Hitoshi Shinotoh, Keisuke Takahata, Shin Kurose, Yasunori Sano, Maiko Ono, Hitoshi Shimada, Kazunori Kawamura, Ming-Rong Zhang, Yuhei Takado, Makoto Higuchi
Publikováno v:
NeuroImage, Vol 264, Iss , Pp 119763- (2022)
Positron emission tomography (PET) with 18F-PM-PBB3 (18F-APN-1607, 18F-Florzolotau) enables high-contrast detection of tau depositions in various neurodegenerative dementias, including Alzheimer's disease (AD) and frontotemporal lobar degeneration (F
Externí odkaz:
https://doaj.org/article/35a5b66d8dcc4f59a4b9f23e33fa7ea0
Autor:
Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Masayuki Fujinaga, Wakana Mori, Katsushi Kumata, Masayuki Hanyu, Kenji Furutsuka, Hiroki Hashimoto, Kazunori Kawamura, Ming-Rong Zhang
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract Background [18F]Fluoromisonidazole ([18F]FMISO) and 1-[18F]fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol ([18F]PM-PBB3 or [18F]APN-1607) are clinically used radiotracers for ima
Externí odkaz:
https://doaj.org/article/eb14fb39ece048dc88b94478b165012f
Autor:
Mai Hatano, Tomoyuki Miyazaki, Yoshinobu Ishiwata, Waki Nakajima, Tetsu Arisawa, Yoko Kuroki, Ayako Kobayashi, Yuuki Takada, Matsuyoshi Ogawa, Kazunori Kawamura, Ming-Rong Zhang, Makoto Higuchi, Masataka Taguri, Yasuyuki Kimura, Takuya Takahashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract [11C]K-2, a radiotracer exhibiting high affinity and selectivity for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), is suitable for the quantification of AMPARs in living human brains and potentially useful in the
Externí odkaz:
https://doaj.org/article/e64e9318174b4b25acffef4f39849587
Autor:
Hiroki Matsumoto, Yukie Yoshii, Atsumi Baden, Emi Kaneko, Hiroki Hashimoto, Hisashi Suzuki, Kazunori Kawamura, Ming-Rong Zhang, Tatsuya Higashi, Hiroaki Kurihara
Publikováno v:
Translational Oncology, Vol 12, Iss 9, Pp 1206-1212 (2019)
Hypoxia plays important roles in the prognosis of malignant brain tumors such as glioblastoma because it causes drug delivery deficiencies and the induction of hypoxia-inducible factor-1α in tumor cells. Extensive hypoxic areas are associated with p
Externí odkaz:
https://doaj.org/article/6d092e0bc1ee40ebadc129e19f156f87
Autor:
Kazunori Kawamura, Wakana Mori, Masayuki Fujinaga, Tomoteru Yamasaki, Yiding Zhang, Hidekatsu Wakizaka, Akiko Hatori, Lin Xie, Katsushi Kumata, Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Ming-Rong Zhang
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 4, Iss 1, Pp 1-13 (2019)
Abstract Background Neuropeptide Y (NPY) has been implicated in a wide variety of physiological processes, including feeding, learning, memory, emotion, cardiovascular homeostasis, hormone secretion, and circadian rhythms. NPY Yl receptor (NPY Y1-R)
Externí odkaz:
https://doaj.org/article/33b5cf6272b34a589f88e299c9316311
Autor:
Takehito Ito, Yasuyuki Kimura, Chie Seki, Masanori Ichise, Keita Yokokawa, Kazunori Kawamura, Hidehiko Takahashi, Makoto Higuchi, Ming-Rong Zhang, Tetsuya Suhara, Makiko Yamada
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-4 (2018)
Abstract Background The histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cognitive functions suc
Externí odkaz:
https://doaj.org/article/c2cb963f0ae84c61975edfcfff3c4460
Autor:
Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Background α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases. We recently developed a
Externí odkaz:
https://doaj.org/article/ccda0efb0af84ee5ab13c5318aab6d87
Autor:
Tomoteru Yamasaki, Masayuki Fujinaga, Joji Yui, Hidekatsu Wakizaka, Tomoyuki Ohya, Nobuki Nengaki, Masanao Ogawa, Yoko Ikoma, Akiko Hatori, Lin Xie, Kazunori Kawamura, Ming-Rong Zhang
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130006 (2015)
Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial target in the development of new medications to treat central nervous system (CNS) disorders. Recently, we developed N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-[11C]meth
Externí odkaz:
https://doaj.org/article/f3cefafae69444f3913d026fcb7a7b84