Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Kazunori Imaizumi"'
Autor:
Nancy Sue, Le May Thai, Atsushi Saito, Cierra K. Boyer, Ashleigh M. Fordham, Chenxu Yan, Aimee Davenport, Jiang Tao, Mohammed Bensellam, James Cantley, Yan-Chuan Shi, Samuel B. Stephens, Kazunori Imaizumi, Trevor J. Biden
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101845- (2024)
Objective: Although individual steps have been characterized, there is little understanding of the overall process whereby glucose co-ordinates the biosynthesis of insulin with its export out of the endoplasmic reticulum (ER) and incorporation into i
Externí odkaz:
https://doaj.org/article/abf43cfa76f149028ed91ecd5b7f85a5
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract The nuclear envelope (NE) is often challenged by various stresses (known as “NE stress”), leading to its dysfunction. Accumulating evidence has proven the pathological relevance of NE stress in numerous diseases ranging from cancer to ne
Externí odkaz:
https://doaj.org/article/eec0359d98c54de798e5f0f6b9ce00d9
Autor:
Yoshiaki Miyake, Masanori Obana, Ayaha Yamamoto, Shunsuke Noda, Koki Tanaka, Hibiki Sakai, Narihito Tatsumoto, Chihiro Makino, Soshi Kanemoto, Go Shioi, Shota Tanaka, Makiko Maeda, Yoshiaki Okada, Kazunori Imaizumi, Katsuhiko Asanuma, Yasushi Fujio
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Upregulation of transcription factor OASIS in podocytes contributes to podocyte and/or tubular injury through decreased PRKCi expression and is a critical event for the disturbance of kidney homeostasis.
Externí odkaz:
https://doaj.org/article/75af94ef692343c8b537f31666d43232
Autor:
Yuji Tsuchikawa, Naosuke Kamei, Yohei Sanada, Toshio Nakamae, Takahiro Harada, Kazunori Imaizumi, Takayuki Akimoto, Shigeru Miyaki, Nobuo Adachi
Publikováno v:
Neural Plasticity, Vol 2023 (2023)
Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complement
Externí odkaz:
https://doaj.org/article/38605a65d28840bead0c570769ec147f
Autor:
Yusuke Fujiwara, Chenyang Ding, Yohei Sanada, Dilimulati Yimiti, Masakazu Ishikawa, Tomoyuki Nakasa, Naosuke Kamei, Kazunori Imaizumi, Martin K. Lotz, Takayuki Akimoto, Shigeru Miyaki, Nobuo Adachi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
Osteoarthritis (OA), the most prevalent aging-related joint disease, is characterized by insufficient extracellular matrix synthesis and articular cartilage degradation and is caused by various risk factors including aging and traumatic injury. Most
Externí odkaz:
https://doaj.org/article/d12359d04f2849089895d50e27a71bbe
Autor:
Yasunao Kamikawa, Atsushi Saito, Koji Matsuhisa, Masayuki Kaneko, Rie Asada, Yasunori Horikoshi, Satoshi Tashiro, Kazunori Imaizumi
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract The nuclear envelope (NE) safeguards the genome and is pivotal for regulating genome activity as the structural scaffold of higher-order chromatin organization. NE had been thought as the stable during the interphase of cell cycle. However,
Externí odkaz:
https://doaj.org/article/1efed8959e3045cd94805274d98b6450
Autor:
Koji Matsuhisa, Kazunori Imaizumi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12227 (2021)
Mucopolysaccharidosis type II (MPS II) results from the dysfunction of a lysosomal enzyme, iduronate-2-sulfatase (IDS). Dysfunction of IDS triggers the lysosomal accumulation of its substrates, glycosaminoglycans, leading to mental retardation and sy
Externí odkaz:
https://doaj.org/article/29447f80ce6c4340a48594f76e92490b
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3921 (2020)
Ubiquitylation plays multiple roles not only in proteasome-mediated protein degradation but also in various other cellular processes including DNA repair, signal transduction, and endocytosis. Ubiquitylation is mediated by ubiquitin ligases, which ar
Externí odkaz:
https://doaj.org/article/38e30a3d0c6b496383e860a9c2178160
Autor:
Yan Wu, Xiao Peng Guo, Soshi Kanemoto, Yujiro Maeoka, Atsushi Saito, Rie Asada, Koji Matsuhisa, Yosuke Ohtake, Kazunori Imaizumi, Masayuki Kaneko
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190407 (2018)
We identified 37 ubiquitin ligases containing RING-finger and transmembrane domains. Of these, we found that RNF183 is abundantly expressed in the kidney. RNF183 predominantly localizes to the endoplasmic reticulum (ER), Golgi, and lysosome. We ident
Externí odkaz:
https://doaj.org/article/e5888133852442acb63d21e9c7f15f0c
Autor:
Atsushi Saito, Kazunori Imaizumi
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3215 (2018)
The function of the endoplasmic reticulum (ER) can be impaired by changes to the extra- and intracellular environment, such as disruption of calcium homeostasis, expression of mutated proteins, and oxidative stress. In response to disruptions to ER h
Externí odkaz:
https://doaj.org/article/e12b6b3e3dbe42fbbdb0a9bd563a4db9