Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Kazunori Hanada"'
Autor:
M. Nozawa, Takatoshi Nagate, Kazuhiko Sugita, Tamejiro Hiyama, Rumi Yamamoto, Toshi Akashi, Akira Onodera, Mikako Fujita, Kiyosi Kondo, Kazunori Hanada, Kazuo Numata, M. Matsuyama, H. Saito, Takeo Kobori, Yoshie Kaneda
Publikováno v:
Chemotherapy. 47:157-169
SC-002 is a novel oral cephalosporin possessing a unique thiadiazolylethenyl moiety at the 3 position. In the present study, it was the most active against gram-positive bacteria among oral cephalosporins such as cefdinir (CFDN), cefpodoxime, cefdito
Autor:
Hiroshi Fukamachi, Hiromitsu Yoshimura, Yumiko Toyoda, Shigeo Morimoto, Hiroshi Hara, Koichiro Shiokawa, Kazunori Hanada, Mari Aoki, Saeko Uchida, Yoshiko Sakai
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492:31-44
By differential cDNA cloning coupled with Xenopus oocyte expression screening, we isolated a cDNA encoding a novel protein, termed ‘hepassocin’, the expression of which is upregulated in the regenerating rat liver. The cDNA contained a single ope
Autor:
Kazutoshi Mizoue, Noriyoshi Sakai, Fumio Mizobe, Renuka Bhandari, Katsumi Kakinuma, Tadashi Eguchi, Mayumi Ito, Kazunori Hanada, Kyoko Ito
Publikováno v:
The Journal of Antibiotics. 52:224-230
During the course of our screening program for low molecular natural products with their ability to potentiate and/or mimic neurotrophic effect of NGF, a novel fungal metabolite, phenylacetic acid hydrazide derivative NG-061 was isolated from the fer
Autor:
Kazutoshi Mizoue, Kyoko Yamamoto, Kazunori Hanada, Noriyoshi Sakai, Yuriko Nozawa, Mayumi Ito, Fumio Mizobe
Publikováno v:
The Journal of Antibiotics. 50:635-640
Stachybotrin C and parvisporin, novel neuritogenic compounds, were isolated from the culture broth of Stachybotrys parvispora F4708. Stachybotrin C induced significant neurite outgrowth in PC12 cells and showed cell survival activity in the primary c
Autor:
Toshi Komurasaki, Kazunori Hanada, Toshiaki Isobe, Daisuke Uchida, Tuneo Okuyama, Hitoshi Toyoda, Yasuko Takayama
Publikováno v:
Journal of Biological Chemistry. 270:7495-7500
Epiregulin, a novel epidermal growth factor (EGF)-related growth regulating peptide, was purified from conditioned medium of the mouse fibroblast-derived tumor cell line NIH3T3/clone T7. It was a 46-amino-acid single chain polypeptide, and its amino
Autor:
Keita Matsumoto, Kazunori Hanada, Terumi Kagamizono, Mari Kishimoto, Zeng-Xiang Chen, Noriyoshi Sakai, Akira Kawashima, Bi-Mei He, Shigeo Morimoto, Emiko Nishino, Takashi Adachi
Publikováno v:
The Journal of Antibiotics. 48:1407-1413
A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-met
Autor:
Teruhiko Beppu, Takashi Adachi, Sueharu Horinouchi, Joji Sasaki, Hiroyuki Kawauchi, Kazunori Hanada
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219:179-183
The gene encoding an enzyme that catalyzes the hydroxylation at position 25 of vitamin D-3 was cloned from an actinomycete strain, Amycolata autotrophica, by use of a host-vector system of Streptomyces lividans. The amino acid sequence deduced from t
Autor:
Kazuaki Kawashima, Jean-Marc Roch, Toshio Miyoshi, Hiroaki Araki, Tsunao Saitoh, Tetsuji Yae, Kyoko Yamamoto, Deborah A. C. Otero, Kazunori Hanada
Publikováno v:
Journal of Neurobiology. 25:585-594
One function of Alzheimer amyloid protein precursor (APP) is the regulation of growth and differentiation in several types of cells, including fibroblasts, PC12 cells, and neurons. This activity is represented by a small stretch of amino acids in the
Autor:
Tadayasu Okazaki, Noriyoshi Sakai, Kazutoshi Mizoue, Mitsuko Seki-Asano, Michio Yamagishi, Kazunori Hanada
Publikováno v:
The Journal of Antibiotics. 47:1226-1233
New 18-membered macrolides FD-891 and FD-892 were discovered from the fermentation broth of Streptomyces graminofaciens A-8890 isolated from a soil sample collected at Yamanashi prefecture Japan. They induce morphological changes of HL-60 cells at lo
Autor:
Kazuo Numata, Mikako Fujita, Rumi Yamamoto, Kazunori Hanada, Toshi Akashi, Takeo Kobori, Takatoshi Nagate, Yoshie Kaneda, Tamejiro Hiyama, Kiyosi Konda, Kazuhiko Sugita
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2225-2230
A series of cephalosporins possessing a [( Z -2-(1,2,3-thiadiazolyl)ethenl] moiety at C-3 were synthesized and their biological properties were examined. SC-002 (1a) exhibited excellent activity against both Gram-positive and Gram-negative bacteria.