Výsledky vyhledávání - "Kazunori Gomi"

Akademický článek

The mast cell exosome-fibroblast connection: A novel pro-fibrotic pathway

Autor: Alexandria Savage, Cristobal Risquez, Kazunori Gomi, Ryan Schreiner, Alain C. Borczuk, Stefan Worgall, Randi B. Silver

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

IntroductionIn addition to the traditional activation of resident receptors by release of local mediators, new evidence favors the existence of exosomes in cell-to-cell communication that mediates delivery of specific cargo to modulate recipient cell

Externí odkaz: https://doaj.org/article/1cb99ceb4853466395190d40fd29eec2

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Akademický článek

Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells

Autor: Ashish Saxena, Matthew S. Walters, Jae-Hung Shieh, Ling-Bo Shen, Kazunori Gomi, Robert J. Downey, Ronald G. Crystal, Malcolm A. S. Moore

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract The human airway epithelium lining the bronchial tree contains basal cells that proliferate, differentiate, and communicate with other components of their microenvironment. One method that cells use for intercellular communication involves t

Externí odkaz: https://doaj.org/article/92449e126f694f7d8e77c16977597922

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Akademický článek

3055 Reconstruction of Patient-specific Distal Airway Regeneration Patterns in COPD

Autor: Seyed Babak Mahjour, Kazunori Gomi, Samir Rustam, Phurbu Dolma, Jamuna Krishnan, Olivier Elemento, Frank D’Ovidio, Timothy S. Blackwell, Scott Randell, Renat Shaykhiev

Publikováno v: Journal of Clinical and Translational Science, Vol 3, Pp 154-154 (2019)

OBJECTIVES/SPECIFIC AIMS: The objective of this study was to reconstruct patient-specific distal airway patterns at the tissue- and single-cell resolution and develop personalized distal airway models based on utilization of patient-derived DABCs and

Externí odkaz: https://doaj.org/article/d6c8c22031494b9c92d7eb944fe8e84f

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Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells

Autor: Robert J. Downey, Malcolm A.S. Moore, Ronald G. Crystal, Kazunori Gomi, Matthew S. Walters, Jae-Hung Shieh, Ling-Bo Shen, Ashish Saxena

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports

The human airway epithelium lining the bronchial tree contains basal cells that proliferate, differentiate, and communicate with other components of their microenvironment. One method that cells use for intercellular communication involves the secret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7100c77e10d6c682c0d3ac9a52ba4abd
https://doaj.org/article/92449e126f694f7d8e77c16977597922

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Akademický článek

2566 Personalized models of distal airway epithelial-stromal unit in COPD

Autor: Seyed B. Mahjour, Kazunori Gomi, Busub Lee, Olivier Elemento, Scott Randell, Renat Shaykhiev

Publikováno v: Journal of Clinical and Translational Science, Vol 2, Pp 23-23 (2018)

OBJECTIVES/SPECIFIC AIMS: The objective of this study is to develop patient-derived “personalized” organotypic models of human distal airways, in which basal stem cells (BCs) isolated from the pre-/terminal conducting airway region are co-culture

Externí odkaz: https://doaj.org/article/4005dca4ffdc4c2d830da0fb87057679

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Akademický článek

Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway.

Autor: Kazunori Gomi, Vanessa Arbelaez, Ronald G Crystal, Matthew S Walters

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0116507 (2015)

Airway basal cells (BC) function as stem/progenitor cells capable of differentiating into the luminal ciliated and secretory cells to replenish the airway epithelium during physiological turnover and repair. The objective of this study was to define

Externí odkaz: https://doaj.org/article/9483e946651348bd88dee3542f9a65b6

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Smoking-Dependent Distal-to-Proximal Repatterning of the Adult Human Small Airway Epithelium

Autor: Busub Lee, Jacqueline Salit, Wu-Lin Zuo, Renat Shaykhiev, Ronald G. Crystal, Kazunori Gomi, IonWa Chao, Tomoya Fukui, Yael Strulovici-Barel, Michelle R. Staudt, Jing Yang, Robert J. Kaner

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 196:340-352

Rationale: Small airways are the primary site of pathologic changes in chronic obstructive pulmonary disease (COPD), the major smoking-induced lung disorder.Objectives: On the basis of the concept of proximal–distal patterning that determines regio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdbcd4f27041b5de5c929e63adc82be8
https://doi.org/10.1164/rccm.201608-1672oc

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Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling

Autor: Ronald G. Crystal, Kazunori Gomi, Yongjiang Tang, Matthew S. Walters, Vanessa Arbelaez

Publikováno v: Stem Cell Reviews and Reports. 13:309-317

Human airway basal cells (BC) function as stem/progenitor cells of the human airway epithelium, capable of differentiating into ciliated and secretory cells during turnover and repair. The positioning of BC along the basement membrane allows for pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1955ddf95f1c7f219ab68c675f24c3b1
https://doi.org/10.1007/s12015-016-9707-z

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