Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kazunobu Kira"'
Autor:
Yuki Sato, Ken Ito, Yoshito Kishi, Takashi Fukuyama, Takeo Sasaki, Isao Ohashi, Kentaro Iso, Takanori Abe, Tsuyoshi Akagi, Kenzo Yahata, Minetaka Isomura, Makoto Asano, Yosuke Kaburagi, Yasunobu Matsumoto, Fumiyoshi Matsuura, Yusuke Miyashita, Takashi Owa, Satoshi Kawano, Kazunobu Kira, Akira Yokoi, Osamu Asano
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Despite their outstanding antitumour activity in mice, the limited supply from the natural sources has prevented drug discovery/development based on intact halichondrins. We achieved a total synthesis of C52-halichondrin-B amine (E7130) on a >10 g sc
Autor:
Yoshito Kishi, Yasunobu Matsumoto, Takashi Fukuyama, Tsuyoshi Akagi, Takashi Owa, Takeo Sasaki, Kazunobu Kira, Yuki Sato, Yosuke Kaburagi, Osamu Asano, Yusuke Miyashita, Isao Ohashi, Minetaka Isomura, Makoto Asano, Takanori Abe, Kentaro Iso, Ken Ito, Fumiyoshi Matsuura, Satoshi Kawano, Kenzo Yahata, Akira Yokoi
Publikováno v:
Cancer Research. 80:4179-4179
Background and objectives: Natural products have been a rich source of inspiration for drug discovery as demonstrated by the fact that over one-third of current therapeutic agents are natural products or compounds derived from them. Particularly, whe
Autor:
Takanori Abe, Yusuke Miyashita, Yasunobu Matsumoto, Kenzo Yahata, Takashi Owa, Kentaro Iso, Yuki Sato, Takeo Sasaki, Yosuke Kaburagi, Minetaka Isomura, Isao Ohashi, Satoshi Kawano, Tsuyoshi Akagi, Makoto Asano, Takashi Fukuyama, Kazunobu Kira, Ken Ito, Fumiyoshi Matsuura, Yoshito Kishi, Osamu Asano, Akira Yokoi
Publikováno v:
Cancer Research. 80:4183-4183
Background and objectives: Despite the outstanding antitumor activity of halichondrins in mice, the limited supply from the natural sources has prevented drug development using intact halichondrins. We achieved a total synthesis of C52-halichondrin-B
Autor:
Huiming Zhang, Linda Lee, Sudeep Prajapati, Betty Chan, Kazunobu Kira, Mingde Shan, Laura Corson, Ming-Hong Hao, Kuo-Ming Wu, O'shea Morgan Welzel, Yoshiharu Mizui, Samantha Perino, John Wang, Eun Sun Park, Lisa A. Marcaurelle, Marta Nevalainen, Arai Kenzo, Guo-Zhu Zheng, Markus Warmuth, Lihua Yu, Atsushi Endo, Jason T. Lowe, Xiang Liu, Baudouin Gerard, Pete Smith, Tivitmahaisoon Parcharee, Craig Karr, Silvia Buonamici, Keaney Gregg F, Tuoping Luo
Publikováno v:
Organic Letters. 16:5560-5563
A total synthesis of the natural product 6-deoxypladienolide D (1) has been achieved. Two noteworthy attributes of the synthesis are (1) a late-stage allylic oxidation which proceeds with full chemo-, regio-, and diastereoselectivity and (2) the deve
Autor:
Toshimi Okada, Nobuyuki Yasuda, Kazuto Yamazaki, Seiji Yoshikawa, Osamu Asano, Tadashi Nagakura, Osamu Takenaka, Richard Clark, Naruo Katsutani, Hironori Ikuta, Takashi Inoue, Isao Tanaka, Fumiyoshi Matsuura, Kazunobu Kira, Takao Saeki, Eita Emori
Publikováno v:
European Journal of Pharmacology. 548:181-187
Dipeptidyl peptidase IV (DPP-IV) inhibitors are expected to become a useful new class of anti-diabetic agent. The aim of the present study is to characterize the in vitro and in vivo profile of E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydr
Autor:
Hiromichi Tanda, Takayuki Baba, Shigeyuki Takai, Minoru Isobe, Akinari Hamajima, Kazunobu Kira
Publikováno v:
Tetrahedron. 58:6485-6492
We have recently reported a hydrosilylation reaction of acetylene cobalt complexes to produce the corresponding vinylsilanes. It has become clear that olefin-isomerization and O-silylation occurred under some hydrosilylation conditions. To avoid thes
Publikováno v:
Tetrahedron. 58:1875-1888
Synthesis of the tricyclic BCD-ring segment with high stereoselectivity has been achieved starting from a sugar derivative directed toward the synthesis of the left part of ciguatoxin 1B. The central reactions in the synthesis are (i) ether ring form
Autor:
Minoru Isobe, Kazunobu Kira
Publikováno v:
Tetrahedron Letters. 42:2821-2824
A synthetic route to the BCDE rings of ciguatoxin 1B has been explored through acetylene biscobalthexacarbonyl complex and vinylsilane strategy. The key issues in the current synthesis are (i) ether ring cyclization by means of the acetylene cobalt c
Autor:
Kazunobu Kira, Minoru Isobe
Publikováno v:
Tetrahedron Letters. 41:5951-5955
A synthetic route to the (D)EF analog of ciguatoxin has been explored through acetylene cobalt complex and vinylsilane strategy. The central reactions in the synthesis are: (i) ether ring formation mediated by acetylene cobalt complex and (ii) decomp
Autor:
Kazunobu Kira, Minoru Isobe
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 58:99-107
Following our previous review of this issue, chemistry of acetylene biscobalthexacarbonyl complex is discussed with special reference in the synthesis of natural and unnatural products. The first example is to do with protein phosphatase inhibitors;