Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Kazunobu, Sawamoto"'
Autor:
Takashi Ogino, Masakazu Agetsuma, Masato Sawada, Hiroyuki Inada, Junichi Nabekura, Kazunobu Sawamoto
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Activation of astrocytes after sensory stimulation has been reported to be involved in increased blood flow in the central nervous system. In the present study, using a chemogenetic method to induce astrocyte activation in mice without senso
Externí odkaz:
https://doaj.org/article/edf68c905da0412eb5d3fec4c29f1626
Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function
Autor:
Mami Matsumoto, Katsuyoshi Matsushita, Masaya Hane, Chentao Wen, Chihiro Kurematsu, Haruko Ota, Huy Bang Nguyen, Truc Quynh Thai, Vicente Herranz-Pérez, Masato Sawada, Koichi Fujimoto, José Manuel García-Verdugo, Koutarou D Kimura, Tatsunori Seki, Chihiro Sato, Nobuhiko Ohno, Kazunobu Sawamoto
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1228-1253 (2024)
Abstract In the injured brain, new neurons produced from endogenous neural stem cells form chains and migrate to injured areas and contribute to the regeneration of lost neurons. However, this endogenous regenerative capacity of the brain has not yet
Externí odkaz:
https://doaj.org/article/38a75c2192bc4cdea63491e9304280eb
Autor:
Chikako Nakajima, Masato Sawada, Erika Umeda, Yuma Takagi, Norihiko Nakashima, Kazuya Kuboyama, Naoko Kaneko, Satoaki Yamamoto, Haruno Nakamura, Naoki Shimada, Koichiro Nakamura, Kumiko Matsuno, Shoji Uesugi, Nynke A. Vepřek, Florian Küllmer, Veselin Nasufović, Hironobu Uchiyama, Masaru Nakada, Yuji Otsuka, Yasuyuki Ito, Vicente Herranz-Pérez, José Manuel García-Verdugo, Nobuhiko Ohno, Hans-Dieter Arndt, Dirk Trauner, Yasuhiko Tabata, Michihiro Igarashi, Kazunobu Sawamoto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Axonal growth cones mediate axonal guidance and growth regulation. We show that migrating neurons in mice possess a growth cone at the tip of their leading process, similar to that of axons, in terms of the cytoskeletal dynamics and function
Externí odkaz:
https://doaj.org/article/eb78cdc0f8c54c43a0de1c4a96db4c3e
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Recent advances in microscopy techniques, especially in electron microscopy, are transforming biomedical studies by acquiring large quantities of high-precision 3D cell image stacks. To examine cell morphology and connectivity in organs such
Externí odkaz:
https://doaj.org/article/d1e31efe06444b08b07d3a48a5980a43
Autor:
Masato Sawada, Ayato Hamaguchi, Naomichi Mano, Yutaka Yoshida, Akiyoshi Uemura, Kazunobu Sawamoto
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/2490f7f120e147c28c04d73f797b05eb
Autor:
Masato Sawada, Ayato Hamaguchi, Naomichi Mano, Yutaka Yoshida, Akiyoshi Uemura, Kazunobu Sawamoto
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Newborn neurons show immature bipolar morphology and continue to migrate toward their destinations. After the termination of migration, newborn neurons undergo spatially controlled dendrite formation and change into a complex morphology. The mechanis
Externí odkaz:
https://doaj.org/article/c9f8480c147d42a49fc67cbb2b9fb0a3
Autor:
Atsuya Yaguchi, Mio Oshikawa, Go Watanabe, Hirotsugu Hiramatsu, Noriyuki Uchida, Chikako Hara, Naoko Kaneko, Kazunobu Sawamoto, Takahiro Muraoka, Itsuki Ajioka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The extracellular matrix contributes to tissue regeneration by binding and releasing growth factors. Here the authors present the jigsaw-shaped self-assembling peptide JigSAP as an artificial ECM and show that VEGF-JigSAP has therapeutic effects on t
Externí odkaz:
https://doaj.org/article/ace4d5be898e4312b4bf35de4601f775
Autor:
Masayasu Okada, Yosuke Kawagoe, Yuta Sato, Motohiro Nozumi, Yuya Ishikawa, Atsushi Tamada, Hiroyuki Yamazaki, Yuko Sekino, Yonehiro Kanemura, Yohei Shinmyo, Hiroshi Kawasaki, Naoko Kaneko, Kazunobu Sawamoto, Yukihiko Fujii, Michihiro Igarashi
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract GAP-43 is a vertebrate neuron-specific protein and that is strongly related to axon growth and regeneration; thus, this protein has been utilized as a classical molecular marker of these events and growth cones. Although GAP-43 was biochemic
Externí odkaz:
https://doaj.org/article/2540b3a6f37f4fde82d0a30e1d40a094
Autor:
Iyo Koyanagi, Kazuhiro Sonomura, Toshie Naoi, Takaaki Ohnishi, Naoko Kaneko, Kazunobu Sawamoto, Taka-Aki Sato, Masanori Sakaguchi
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Metabolites underlying brain function and pathology are not as well understood as genes. Here, we applied a novel metabolomics approach to further understand the mechanisms of memory processing in sleep. As hippocampal dentate gyrus neurons
Externí odkaz:
https://doaj.org/article/6ecb6c232ac941b4b3c4812af99dba55
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)
Abstract In many mammalian species, the production of new neurons in the hippocampal dentate gyrus continues throughout life. Previous studies using rodents suggest that adult-born neurons are involved in memory and cognition tasks and mood regulatio
Externí odkaz:
https://doaj.org/article/2205a0d5d48f4406834c3fe712fcac44