Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Kazunari Sekiyama"'
Autor:
Yoshiki Takamatsu, Gilbert Ho, Wakako Koike, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Jianshe Wei, Kazunari Sekiyama, Makoto Hashimoto
Publikováno v:
npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-10 (2017)
Abstract Protein aggregation is a pathological hallmark of and may play a central role in the neurotoxicity in age-associated neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Accordingly, inhibiting aggregation of
Externí odkaz:
https://doaj.org/article/bc8a805344ac428e9accaa32a0c1f422
Publikováno v:
Biomolecules, Vol 5, Iss 2, Pp 1000-1011 (2015)
Axonal swellings are histological hallmarks of axonopathies in various types of disorders in the central nervous system, including neurodegenerative diseases. Given the pivotal role of axonopathies during the early phase of neurodegenerative process,
Externí odkaz:
https://doaj.org/article/89141edc7b1e4788af2bd8e58c40ebc5
Autor:
Kazunari Sekiyama, Shuei Sugama, Masayo Fujita, Akio Sekigawa, Yoshiki Takamatsu, Masaaki Waragai, Takato Takenouchi, Makoto Hashimoto
Publikováno v:
Parkinson's Disease, Vol 2012 (2012)
Neuroinflammation in Parkinson's disease (PD) is a chronic process that is associated with alteration of glial cells, including astrocytes and microglia. However, the precise mechanisms remain obscure. To better understand neuroinflammation in PD, we
Externí odkaz:
https://doaj.org/article/b74e8b59a4bf4859935cede3a778cc9c
Autor:
Gilbert J. Ho, Willie Liang, Masaaki Waragai, Kazunari Sekiyama, Eliezer Masliah, Makoto Hashimoto
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Recent advances have been made in defining the genetic and molecular basis of dementia with Lewy bodies (DLBs) and related neurodegenerative disorders such as Parkinson's disease (PD) and Parkinson's disease dementia (PDD) which comprise the spectrum
Externí odkaz:
https://doaj.org/article/dfe88778ce9b4f60aadae05e4bb79e88
Autor:
Hiroaki Ishida, Mitsuhiro Miyashita, Kenichi Oshima, Ito Kawakami, Kazunari Sekiyama, Mai Kounoe, Erika Seki, Nobutaka Arai, Shunya Takizawa, Eiichiro Nagata, Masanari Itokawa, Makoto Arai
Publikováno v:
Psychiatry Research Case Reports. 1:100064
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe2532311d97a0bd34c206ad1d5c4226
https://doi.org/10.1016/j.psycr.2022.100064
https://doi.org/10.1016/j.psycr.2022.100064
Publikováno v:
The Journal of Veterinary Medical Science
Activin E, a secreted peptide encoded by the inhibin/activin βE subunit gene, is a member of the transforming growth factor-β superfamily, which is predominantly expressed in the liver. Recent reports have suggested that activin E plays a role in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163aab913f257d46b09f33341dd58eef
http://europepmc.org/articles/PMC6541856
http://europepmc.org/articles/PMC6541856
Autor:
Shigenobu Matsumura, Makoto Sugiyama, Kazunari Sekiyama, Hitomi Takada, Masayuki Funaba, Akira Kurisaki, Kazuo Inoue, Ryo Satoh, Osamu Hashimoto, Seiichi Oyadomari, Chisato Suzuki, Hiroaki Oiwa, Norio Yamakawa, Hiromu Sugino, Satoru Doi, Masahiro Morita, Daichi Shindo, Hiroshi Itoi
Publikováno v:
Cell Reports. 25(5):1193-1203
Brown adipocyte activation or beige adipocyte emergence in white adipose tissue (WAT) increases energy expenditure, leading to a reduction in body fat mass and improved glucose metabolism. We found that activin E functions as a hepatokine that enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb6bb8a84b61ca2d759df54743c8a09
http://repo.lib.tokushima-u.ac.jp/115050
http://repo.lib.tokushima-u.ac.jp/115050
Autor:
Takato Takenouchi, Kazunari Sekiyama, Yoshiki Takamatsu, Gilbert Ho, Shuei Sugama, Eliezer Masliah, Makoto Hashimoto, Masaaki Waragai
Publikováno v:
Annals of Clinical and Translational Neurology
A recent study suggested that insulin resistance may play a central role in the pathogenesis of Alzheimer's disease (AD). In this regard, it is of note that upregulation of plasma adiponectin (APN), a benign adipokine that sensitizes the insulin rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069e22180e544df3c781400ad5f4a7e6
https://doi.org/10.1002/acn3.436
https://doi.org/10.1002/acn3.436
Autor:
Anthony Adame, Kazunari Sekiyama, Makoto Hashimoto, Kaori Une, Eliezer Masliah, Yoshiki Takamatsu, Ivy Trinh, Masaaki Waragai
Publikováno v:
Journal of Alzheimer's Disease. 52:1453-1459
Adiponectin (APN) is protective in animal models of neurodegenerative diseases, but the role of APN in human brain has not been established. Using an enzyme-linked immunosorbent assay, we found that APN was significantly decreased in cerebrospinal fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61525f53b32ed1183ffd502776c4db83
https://doi.org/10.3233/jad-151116
https://doi.org/10.3233/jad-151116
Autor:
Makoto Hashimoto, Wakako Koike, Yoshiki Takamatsu, Takato Takenouchi, Kazunari Sekiyama, Masaaki Waragai, Shuei Sugama
Publikováno v:
Journal of Alzheimer's Disease. 52:831-841
Recent clinical trials using immunization approaches against Alzheimer's disease (AD) have failed to demonstrate improved cognitive functions in patients, despite potent suppression in the formation of both senile plaques and other amyloid-β deposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32ad11c426abb2a47244e76c6e124c1
https://doi.org/10.3233/jad-151015
https://doi.org/10.3233/jad-151015