Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kazunari Iwamoto"'
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-21 (2020)
Abstract Background Studies using quantitative experimental methods have shown that intracellular spatial distribution of molecules plays a central role in many cellular systems. Spatially resolved computer simulations can integrate quantitative data
Externí odkaz:
https://doaj.org/article/4796a67dd3a74050a343e8735b8a6b47
Autor:
Yuki Shindo, Kazunari Iwamoto, Kazunari Mouri, Kayo Hibino, Masaru Tomita, Hidetaka Kosako, Yasushi Sako, Koichi Takahashi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
While ERK signalling can produce switch-like cell behaviour, phosphorylation of ERK increases linearly with extracellular signals. Here, the authors solve this seeming contradiction by showing that nuclear translocation of ERK behaves in a switch-lik
Externí odkaz:
https://doaj.org/article/060548370a304893a89d1d715f0dd5dd
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 11, p e1005222 (2016)
Cellular heterogeneity, which plays an essential role in biological phenomena, such as drug resistance and migration, is considered to arise from intrinsic (i.e., reaction kinetics) and extrinsic (i.e., protein variability) noise in the cell. However
Externí odkaz:
https://doaj.org/article/d6ad40cd93cf42e5825f0cf9072035ea
Autor:
Masaki Watabe, Satya N V Arjunan, Seiya Fukushima, Kazunari Iwamoto, Jun Kozuka, Satomi Matsuoka, Yuki Shindo, Masahiro Ueda, Koichi Takahashi
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0130089 (2015)
Using bioimaging technology, biologists have attempted to identify and document analytical interpretations that underlie biological phenomena in biological cells. Theoretical biology aims at distilling those interpretations into knowledge in the math
Externí odkaz:
https://doaj.org/article/5eec631ed5974f89a9afb9438230147d
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101333 (2014)
A massive integrative mathematical model of DNA double-strand break (DSB) generation, DSB repair system, p53 signaling network, and apoptosis induction pathway was constructed to explore the dominant factors of unknown criteria of cell fate decision.
Externí odkaz:
https://doaj.org/article/b1c13f2ee7db490ab0350554241e81c2
Autor:
Hiroyuki Hamada, Yoshihiko Tashima, Yu Kisaka, Kazunari Iwamoto, Taizo Hanai, Yukihiro Eguchi, Masahiro Okamoto
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4795 (2009)
The tumor suppressor, p53, regulates several gene expressions that are related to the DNA repair protein, cell cycle arrest and apoptosis induction, which activates the implementation of both cell cycle arrest and induction of apoptosis. However, it
Externí odkaz:
https://doaj.org/article/bd086858986b4a93869100f31e76b01f
Autor:
Kazunari Iwamoto, Tore Eriksson
By utilizing functional genetic variation within the participants of the UK Biobank project for a largescale PheWAS study we attempted to get a better understanding of how the set of human proteases and their endogenous inhibitors are involved in com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b24ac97360667fa1d135c4608588ed3f
https://doi.org/10.1101/2022.06.30.498364
https://doi.org/10.1101/2022.06.30.498364
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-21 (2020)
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-21 (2020)
Background Studies using quantitative experimental methods have shown that intracellular spatial distribution of molecules plays a central role in many cellular systems. Spatially resolved computer simulations can integrate quantitative data from the
Autor:
Akira, Imamoto, Sewon, Ki, Leiming, Li, Kazunari, Iwamoto, Venkat, Maruthamuthu, John, Devany, Ocean, Lu, Tomomi, Kanazawa, Suxiang, Zhang, Takuji, Yamada, Akiyoshi, Hirayama, Shinji, Fukuda, Yutaka, Suzuki, Mariko, Okada
Publikováno v:
Life Science Alliance
This study presents evidence that CRK/CRKL and TBX1 may share pathways that participate in organogenesis affected in DiGeorge syndrome (22q11.2DS) via global control of gene expression and metabolism
CRK and CRKL (CRK-like) encode adapter protei
CRK and CRKL (CRK-like) encode adapter protei
Publikováno v:
Current Opinion in Systems Biology. 2:39-48
Cancer phenotypes, referred to as hallmarks of cancer, are acquired by dysregulation of biochemical networks, in addition to genetic and epigenetic alterations. For the last decade, systems biology approaches, a combination of mathematical modeling a