Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kazunari Hattori"'
Autor:
Felix DeAnda, Kendra E Hightower, Robert T Nolte, Kazunari Hattori, Tomokazu Yoshinaga, Takashi Kawasuji, Mark R Underwood
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77448 (2013)
Signature HIV-1 integrase mutations associated with clinical raltegravir resistance involve 1 of 3 primary genetic pathways, Y143C/R, Q148H/K/R and N155H, the latter 2 of which confer cross-resistance to elvitegravir. In accord with clinical findings
Externí odkaz:
https://doaj.org/article/c236911bda2245a0833c118568cf3e4c
Autor:
Yoshiyuki Taoda, Toshiyuki Akiyama, Tomokazu Yoshinaga, Masayoshi Miyagawa, Kenji Tomita, Kenji Takaya, Kazunari Hattori, Shinya Shano, Takao Shishido, Akihiko Sato, Kazuya Yasuo, Makoto Kawai, Ryu Yoshida, Chika Takahashi-Kageyama
Publikováno v:
Journal of Medicinal Chemistry. 62:8101-8114
The medicinal chemistry and structure-activity relationships (SAR) for a novel series of carbamoyl pyridone bicycle (CAB) compounds as influenza Cap-dependent endonuclease (CEN) inhibitors are disclosed. Substituent effects were evaluated at the C (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fd1bffabc6a51353f66d1bfe6f33a8
https://doi.org/10.1021/acs.jmedchem.9b00861
https://doi.org/10.1021/acs.jmedchem.9b00861
Autor:
Akihiko Sato, Kouhei Matsui, Yoshito Numata, Haruka Maeda, Youhei Takagi, Yasuko Orba, Yutaka Yoshida, Kazunari Hattori, Hirofumi Sawa, Takeshi Kurosu, Haruaki Nobori, Kenichi Higashino
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3586-3590
NS2B-NS3 protease is an essential enzyme for the replication of dengue virus (DENV), which continues to be a serious threat to worldwide public health. We designed and synthesized a series of cyclic peptides mimicking the substrates of this enzyme, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456d655031c46510cbd27f8309a5eaac
https://doi.org/10.1016/j.bmcl.2017.05.027
https://doi.org/10.1016/j.bmcl.2017.05.027
Autor:
Masatoshi Okamatsu, Keiichi Taniguchi, Masanori Kobayashi, Kayo Ishida, Takao Shishido, Keiko Baba, Yoshihiro Sakoda, Yukihiro Kushima, Tomokazu Yoshinaga, Mitsutaka Kitano, Akihiko Sato, Atsuko Yamamoto, Takeshi Noshi, Makoto Kawai, Hiroshi Kida, Kazunari Hattori, Akira Naito, Shinya Omoto, Ryu Yoshida, Takashi Hashimoto
Publikováno v:
Antiviral research. 160
Cap-dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical "cap-snatching" step of viral RNA transcription, which is considered to be a promising anti-influenza target. Here, we describe in vitro chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98074607d75a90d3f2ba4d6ca12ad19
https://pubmed.ncbi.nlm.nih.gov/30316915
https://pubmed.ncbi.nlm.nih.gov/30316915
Autor:
Hidekuni Yamakawa, Yoshikazu Tanaka, Toru Nakano, Takahiko Yamamoto, Kazunari Hattori, Kenichiro Fujiwara, Satoshi Shuto, Shuji Yonezawa, Hiroshi Takemoto, Mitsuhiro Arisawa, Motoko Hosono, Chie Muto
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6506-6522
For further investigation of BACE1 inhibitors using conformational restriction with sp(3) hybridized carbon, we applied this approach to 6-substituted aminopyrimidone derivatives 3 to improve the inhibitory activity by reducing the entropic energy lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babb92374a1c212e0797d285d00bc12b
https://doi.org/10.1016/j.bmc.2013.08.036
https://doi.org/10.1016/j.bmc.2013.08.036
Autor:
Takao Shishido, Minako Mikamiyama-Iwata, Yoshiyuki Taoda, Tomokazu Yoshinaga, Ryu Yoshida, Naoko Kurihara, Naoyuki Suzuki, Kenji Morimoto, Noriyuki Kurose, Masayoshi Miyagawa, Hidenori Mikamiyama, Makoto Kawai, Kazunari Hattori, Kenji Tomita, Chika Takahashi-Kageyama, Toshiyuki Akiyama, Kenji Matsuo, Kenji Takaya, Akihiko Sato
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(19)
We report the discovery of a novel series of influenza Cap-dependent EndoNuclease (CEN) inhibitors based on the 4-pyridone-carboxylic acid (PYXA) scaffold, which were found from our chelate library. Our SAR research revealed the lipophilic domain to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69232b20f8a66fc4e31959854f6ec6a1
https://pubmed.ncbi.nlm.nih.gov/27568084
https://pubmed.ncbi.nlm.nih.gov/27568084
Autor:
Takaaki Maeda, Hirokazu Higuchi, Kazunari Hattori, Yoshiyuki Yoshinaka, Toshiki Kitabayashi, Yoshimi Yonemoto
Publikováno v:
Horticultural Research (Japan). 10:267-272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4cbb530959b1ca51ef9c055e0346c5f
https://doi.org/10.2503/hrj.10.267
https://doi.org/10.2503/hrj.10.267
Autor:
Makoto Kawai, Yoshinori Murata, Mio Sakai, Atsushi Omura, Kazunari Hattori, Shinichi Sakemi, Yoko Matsuoka, Ivan J. Samardjiev, Jon Bordner, Morimichi Sato, Takashi Kojima, Takashi Mano
Publikováno v:
International Journal of Pharmaceutics. 355:337-340
(−)-6-{2-[4-(3-Fluorophenyl)-4-hydroxy-piperidin-1-yl]-1-hydroxyethyl}-3,4-dihydro-quinolin-2(1H)-one (compound A) is an NR2B selective N -methyl d -aspartate (NMDA) antagonist that has shown at least two polymorphs, forms I and II. In this report,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8050a9ed33b14d0a18ce1e4c46305dd
https://doi.org/10.1016/j.ijpharm.2007.11.060
https://doi.org/10.1016/j.ijpharm.2007.11.060
Autor:
Misaki Suzuki, Takashi Moriya, Kazunari Hattori, Kaoru Shimada, Yojiro Sakiyama, Hitomi Yuki, Teruki Honma
Publikováno v:
Journal of Molecular Graphics and Modelling. 26:907-915
To ensure a continuing pipeline in pharmaceutical research, lead candidates must possess appropriate metabolic stability in the drug discovery process. In vitro ADMET (absorption, distribution, metabolism, elimination, and toxicity) screening provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b7218904fa8a0efb2916af9f4deec9
https://doi.org/10.1016/j.jmgm.2007.06.005
https://doi.org/10.1016/j.jmgm.2007.06.005
Publikováno v:
Journal of Chemical Information and Modeling. 48:135-142
In drug discovery programs, predicting key example compounds in competitors' patent applications is important work for scientists working in the same or in related research areas. In general, medicinal chemists are responsible for this work, and they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85be235865e0fca402215fae478e035c
https://doi.org/10.1021/ci7002686
https://doi.org/10.1021/ci7002686