AJM300 (carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled, phase 3 study

Autor: Katsuyoshi Matsuoka, Mamoru Watanabe, Toshihide Ohmori, Koichi Nakajima, Tetsuya Ishida, Yoh Ishiguro, Kazunari Kanke, Kiyonori Kobayashi, Fumihito Hirai, Kenji Watanabe, Hidehiro Mizusawa, Shuji Kishida, Yoshiharu Miura, Akira Ohta, Toshifumi Kajioka, Toshifumi Hibi, Satoshi Motoya, Atsuo Maemoto, Mikihiro Fujiya, Toshifumi Ashida, Mitsuru Goto, Takayuki Matsumoto, Yasuo Suzuki, Yukihiro Hamahata, Tomoo Nakagawa, Naoya Kato, Jun Kato, Yutaka Endo, Ryoichi Suzuki, Koichiro Matsuda, Naoki Ohmiya, Shinji Katsushima, Shuhei Hosomi, Ken-ichi Tarumi, Chiyuki Watanabe, Mitsuru Saito, Yuichiro Yokoyama, Tomoki Inaba, Yasuhisa Sakata, Hitoshi Hongo, Tomoyoshi Shibuya, Kazuhiko Kawakami, Yoichi Kakuta, Atsushi Irisawa, Naoki Yoshimura, Katsuyuki Fukuda, Takayuki Shirai, Hitoshi Ichikawa, Junko Nagata, Takayoshi Suzuki, Kaoru Yokoyama, Takashi Tomidokoro, Yuichiro Kojima, Masahiro Yamada, Hideko Yamamoto, Takayuki Yamamoto, Noriyuki Horiki, Hirozumi Obata, Satoko Inoue, Shinji Tanaka, Tatsuya Toyokawa, Masaki Kunihiro, Takashi Hisabe, Shinichi Ogata, Fuminao Takeshima, Kayoko Matsushima, Nobuyuki Matsuhashi, Hirotake Sakuraba, Masahiro Iwabuchi, Akihiko Tsuchiya, Kan Uchiyama, Takanori Kanai, Masanao Nakamura, Tadashi Yokoyama, Nobuyuki Hida, Keiichi Mitsuyama, Taro Osada, Sakiko Hiraoka, Tomoyuki Tsuzuki, Takashige Masuo, Ryota Hokari, Taku Kobayashi, Masayuki Saruta, Masao Araki, Hiroshi Araki, Masahito Shimizu, Masakazu Kikuchi, Takahiro Nishikawa, Hidetoshi Takedatsu, Kunihiko Aoyagi, Toshiaki Ochiai, Nobuo Toda, Yuji Mizokami, Masakazu Nagahori, Kazuhiro Matsueda, Hitoshi Kino, Akira Kanamori, Tsunehiro Suzuki, Toshiharu Sakurai, Masatoshi Kudo, Atsuo Kitano, Tadakazu Hisamatsu, Shinji Kumagai, Tomoyuki Ninomiya, Kenichiro Mori, Shun-ichi Yoshida, Mitsuhide Goto

Publikováno v: The lancet. Gastroenterologyhepatology. 7(7)

AJM300 is an oral, small-molecule α4-integrin antagonist. We assessed the efficacy and safety of AJM300 in patients with moderately active ulcerative colitis.This multicentre, randomised, double-blind, placebo-controlled, phase 3 study consisted of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09095d091fd13d05f8f0e8950f2cdefb
https://pubmed.ncbi.nlm.nih.gov/35366419

Randomised clinical trial: rabeprazole improves symptoms in patients with functional dyspepsia in Japan

Autor: Akihito Nagahara, Kazuhide Higuchi, Hironori Masuyama, Hiroto Miwa, Yoshikazu Kinoshita, Yuji Naito, Michio Hongo, Shin Ichi Takahashi, Kazunari Tominaga, T Arakawa, Sumio Watanabe, Takahisa Furuta, Ken Haruma, Kazuma Fujimoto, Koichiro Furuta, Masahiko Inamori, Masako Kato, Kazunari Kanke, Motoyasu Kusano, Ryuichi Iwakiri, Katsuhiko Iwakiri, Hideyuki Hiraishi

Publikováno v: Alimentary Pharmacology & Therapeutics. 38:729-740

SummaryBackground The efficacy of proton pump inhibitors (PPIs) for treating functional dyspepsia (FD) is not well established. Aim This study, named the SAMURAI study, aimed to assess the efficacy and dose–response relationship of rabeprazole in J

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1d335e5a09d08e4df041d1652856c6
https://doi.org/10.1111/apt.12444

An Open-Label Prospective Randomized Multicenter Study Shows Very Rapid Remission of Ulcerative Colitis by Intensive Granulocyte and Monocyte Adsorptive Apheresis as Compared With Routine Weekly Treatment

Autor: Toshiyuki Matsui, Masahiro Iizuka, Ken Fukunaga, Naoki Yoshimura, Satoshi Motoya, Toshifumi Ashida, Kazunari Kanke, Yasuo Suzuki, Reiko Kunisaki, Tadayuki Oshima, Takayuki Matsumoto, Toshimi Chiba, Taiji Akamatsu, Yohei Mizuta, Masakazu Nishishita, Kenji Watanabe, Nobuo Aoyama, Akira Andoh, Atsushi Sakuraba, Hiroyuki Hanai, Shinsuke Funakoshi, Ryoichi Suzuki, Toshifumi Hibi, Hiroshi Nakase

Publikováno v: American Journal of Gastroenterology. 104:2990-2995

Granulocyte and monocyte adsorptive apheresis (GMA) has shown efficacy in patients with active ulcerative colitis (UC). However, with routine weekly treatment, it may take several weeks to achieve remission, and to date, the efficacy of a more freque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90bda1dd348facd1764dc182909319d6
https://doi.org/10.1038/ajg.2009.453

Evaluation of the excluded stomach by double-balloon endoscopy after laparoscopic Roux-en-Y gastric bypass

Autor: Eiji Kanehira, Kazunari Kanke, Kazunori Kasama, Youichirou Fujii, Hideyuki Hiraishi, Osamu Zaha, Susumu Inamine, Nobumi Tagaya, Keiichi Kubota

Publikováno v: Obesity Surgery. 17:1165-1170

Morbid obesity has become a serious health problem. We have been performing laparoscopic Roux-en-Y gastric bypass (LRYGBP) for morbid obesity since February 2002. Although LRYGBP ameliorates complications of morbid obesity, postoperative investigatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b85f40835a1c4034930c2e0002a713f
https://doi.org/10.1007/s11695-007-9198-8

Comparison between endoscopic papillary balloon dilatation and endoscopic sphincterotomy for the treatment of common bile duct stones

Autor: Hidetaka Watanabe, Akira Terano, Hideyuki Hiraishi, Tsuneo Monma, Masashi Yoneda, Tadahito Shimada, Keiichi Tominaga, Kazunari Kanke

Publikováno v: Journal of Gastroenterology. 42:56-62

This study was designed to evaluate the therapeutic outcome and early postoperative complications, especially pancreatitis, of endoscopic papillary balloon dilation (EPBD) and endoscopic sphincterotomy (EST) in patients with common bile duct stones i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d4fc25261ce84f87c86a363cac4a39
https://doi.org/10.1007/s00535-006-1969-9