Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Kazumitsu, Onizuka"'
Autor:
Ryosuke Nagasawa, Kazumitsu Onizuka, Kaoru R. Komatsu, Emi Miyashita, Hirotaka Murase, Kanna Ojima, Shunya Ishikawa, Mamiko Ozawa, Hirohide Saito, Fumi Nagatsugi
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The large-scale analysis of small-molecule binding to diverse RNA structures is key to understanding the required interaction properties and selectivity for developing RNA-binding molecules toward RNA-targeted therapies. Here, we report a ne
Externí odkaz:
https://doaj.org/article/bbdf0269db2a48d087621a94d351d428
Autor:
Robert P Fuchs, Asako Isogawa, Joao A Paulo, Kazumitsu Onizuka, Tatsuro Takahashi, Ravindra Amunugama, Julien P Duxin, Shingo Fujii
Publikováno v:
eLife, Vol 10 (2021)
Temozolomide (TMZ), a DNA methylating agent, is the primary chemotherapeutic drug used in glioblastoma treatment. TMZ induces mostly N-alkylation adducts (N7-methylguanine and N3-methyladenine) and some O6-methylguanine (O6mG) adducts. Current models
Externí odkaz:
https://doaj.org/article/0d670b1a8f304282bd6a3a696de67cd0
Publikováno v:
Chemistry Letters. 51:1121-1124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd1c1018bfdbfd0605ab15f02e514e3c
https://doi.org/10.1246/cl.220397
https://doi.org/10.1246/cl.220397
Publikováno v:
Bioconjugate Chemistry. 33:2097-2102
Alkylating agents for nucleic acids have been widely used in cancer chemotherapy, as well as in chemical biology for strong inhibitors and tagging methods. We provide a series of reactive OFF-ON type alkylating agents which enable the reactivity modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e89b8144de9d2a4b9b7a6ede308e99
https://doi.org/10.1021/acs.bioconjchem.2c00458
https://doi.org/10.1021/acs.bioconjchem.2c00458
Autor:
Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Kei Ishida, Sayaka Yajima, Eriko Mano, Fumi Nagatsugi
Publikováno v:
The Journal of Organic Chemistry. 87:2267-2276
Specific chemical reactions by enzymes acting on a nucleobase are realized by flipping the target base out of the helix. Similarly, artificial oligodeoxynucleotides (ODNs) can also induce the base flipping and a specific chemical reaction. We now rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b38bdc56b3cef5b9796c202acc7ebb4
https://doi.org/10.1021/acs.joc.1c01498
https://doi.org/10.1021/acs.joc.1c01498
Autor:
Fumi Nagatsugi, Kazumitsu Onizuka
Publikováno v:
The Chemical Record. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9b2d6b1c6661f63b684dbef1981f61d
https://doi.org/10.1002/tcr.202380201
https://doi.org/10.1002/tcr.202380201
Autor:
Fumi Nagatsugi, Kazumitsu Onizuka
Publikováno v:
Chemical record (New York, N.Y.).
DNA and RNA can adopt a variety of stable higher-order structural motifs, including G-quadruplex (G4 s), mismatches, and bulges. Many of these secondary structures are closely related to the regulation of gene expression. Therefore, the higher-order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25558c14055cf703df9d9356d85269fb
https://pubmed.ncbi.nlm.nih.gov/36111635
https://pubmed.ncbi.nlm.nih.gov/36111635
Autor:
Erchissaran Ganbold, Yutong Chen, Madoka E. Hazemi, Norihiro Sato, Kazumitsu Onizuka, Mamiko Ozawa, Fumi Nagatsugi, Shogo Sasaki, Yue Ma, Kazuo Nagasawa
Publikováno v:
Organic & Biomolecular Chemistry. 19:2891-2894
The selective alkylation of nucleic acids is important for a medicinal approach and biological study. We now report a novel selective alkylation of the parallel G-quadruplex structure using the conjugate of the macrocyclic hexaoxazole L2G2-6OTD-1M1PA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9569e3910125232ca39b96ba6bd0d48
https://doi.org/10.1039/d0ob02365e
https://doi.org/10.1039/d0ob02365e
Autor:
Ahmed Mostafa, Abdelhady, Yu, Hirano, Kazumitsu, Onizuka, Hidenori, Okamura, Yasuo, Komatsu, Fumi, Nagatsugi
Publikováno v:
Current Protocols. 2
Crosslinking reactions to nucleic acids are an effective way to prepare stable complexes formed by covalent bonding. We demonstrated that fully 2'-O-methylated (2'-OMe) RNAs having a 2-amino-6-vinylpurine (AVP) exhibited an efficient crosslinking to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a58e6a9f259adb675098c9a70a53d2
https://doi.org/10.1002/cpz1.386
https://doi.org/10.1002/cpz1.386
Autor:
Fumi Nagatsugi, Kazumitsu Onizuka
Publikováno v:
Chemistry Letters. 49:771-780
Guanine (G)-rich sequences can form non-canonical four stranded structures known as G-quadruplexes (G4s). The G4 structure has been found in biologically significant regions of the genomic DNA, and...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae6601b51dbe295965ffe578d7bcf2c
https://doi.org/10.1246/cl.200214
https://doi.org/10.1246/cl.200214